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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review


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Disease relevance of Orchitis

  • None of 24 sera from men with seminomas and none of 5 sera from men with orchitis had elevated SP1 [1].
  • 5HT, the immediate stimulus of testicular CRF secretion, is released during stress and is locally increased in the testis in pathological conditions associated with impaired testicular function (i.e., orchitis, varicocele) [2].
  • We report 8 patients with Wegener granulomatosis (WG) who suffered from symptomatic urogenital involvement including acute urinary retention related to prostatitis, orchitis, ureteral stenosis, bladder pseudotumor, and penile ulceration [3].
  • Hence, the aging AROM+ males present with a phenocopy of inflammation-associated infertility in men, providing a model for further studies on the putative link among estrogens, orchitis, and infertility [4].
  • The serum CRP titers were significantly higher in the patients with orchitis than in those with meningitis [5].

High impact information on Orchitis

  • In two rabbits with higher levels of circulating antisperm antibodies and severe orchitis, granular deposits of IgG and C3 were also present in renal glomeruli [6].
  • Acute orchitis in familial Mediterranean fever [7].
  • Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis [8].
  • Adeno-associated virus-mediated human IL-10 gene transfer suppresses the development of experimental autoimmune orchitis [9].
  • In mink with secondary infertility, the frequency and degree of orchitis and testicular immune complexes increased from March (peak sexual activity) to April (onset of testicular regression) [10].

Chemical compound and disease context of Orchitis

  • Ciprofloxacin or clavulanic acid/amoxicillin was administered as bacterial orchitis could not be excluded at initial presentation [11].
  • Thus, B. pertussis-induced sensitivity to histamine appears to play a more crucial role during the sensitization phase of autoimmune orchitis induction, rather than at the inflammatory or effector phase of the disease [12].
  • Moreover, rats with orchitis had significantly increased testicular testosterone [13].
  • The effects of the treatment with the immunosuppressant deoxyspergualin on the development of experimental autoimmune orchitis were studied [14].
  • The increase in testicular steroidogenesis without a concomitant enhancement in serum LH levels detected in rats with autoimmune orchitis suggests the existence of local control mechanisms [13].

Biological context of Orchitis


Anatomical context of Orchitis


Gene context of Orchitis


  1. Increased "pregnancy-specific" beta1-glycoprotein in certain nonseminomatous germ cell tumors. Rosen, S.W., Javadpour, N., Calvert, I., Kaminska, J. J. Natl. Cancer Inst. (1979) [Pubmed]
  2. Corticotropin-releasing factor: an antireproductive hormone of the testis. Dufau, M.L., Tinajero, J.C., Fabbri, A. FASEB J. (1993) [Pubmed]
  3. Urogenital manifestations of Wegener granulomatosis. Huong, D.L., Papo, T., Piette, J.C., Wechsler, B., Bletry, O., Richard, F., Valcke, J.C., Godeau, P. Medicine (Baltimore) (1995) [Pubmed]
  4. Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis. Li, X., Strauss, L., Kaatrasalo, A., Mayerhofer, A., Huhtaniemi, I., Santti, R., Mäkelä, S., Poutanen, M. Endocrinology (2006) [Pubmed]
  5. Elevated serum C-reactive protein in mumps orchitis. Niizuma, T., Terada, K., Kosaka, Y., Daimon, Y., Inoue, M., Ogita, S., Kataoka, N., Tanaka, K. Pediatr. Infect. Dis. J. (2004) [Pubmed]
  6. Immune complex orchitis in vasectomized rabbits. Bigazzi, P.E., Kosuda, L.L., Hsu, K.C., Andres, G.A. J. Exp. Med. (1976) [Pubmed]
  7. Acute orchitis in familial Mediterranean fever. Eshel, G., Zemer, D., Bar-Yochai, A. Ann. Intern. Med. (1988) [Pubmed]
  8. Multiple loci govern the bone marrow-derived immunoregulatory mechanism controlling dominant resistance to autoimmune orchitis. Meeker, N.D., Hickey, W.F., Korngold, R., Hansen, W.K., Sudweeks, J.D., Wardell, B.B., Griffith, J.S., Teuscher, C. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. Adeno-associated virus-mediated human IL-10 gene transfer suppresses the development of experimental autoimmune orchitis. Watanabe, M., Kashiwakura, Y., Kusumi, N., Tamayose, K., Nasu, Y., Nagai, A., Shimada, T., Daida, H., Kumon, H. Gene Ther. (2005) [Pubmed]
  10. The dark mink: a model of male infertility. Tung, K.S., Ellis, L.E., Childs, G.V., Dufau, M. Endocrinology (1984) [Pubmed]
  11. Mumps orchitis: report of a mini-epidemic. Casella, R., Leibundgut, B., Lehmann, K., Gasser, T.C. J. Urol. (1997) [Pubmed]
  12. Experimental allergic orchitis in mice. II. Association of disease susceptibility with the locus controlling Bordetella pertussis-induced sensitivity to histamine. Teuscher, C. Immunogenetics (1985) [Pubmed]
  13. Alterations of testicular function after induced autoimmune orchitis in rats. Suescun, M.O., Calandra, R.S., Lustig, L. J. Androl. (1994) [Pubmed]
  14. Short-term prophylaxis with deoxyspergualin prevents testicular autoimmunity in mice. Ablake, M., Itoh, M., Kaneko, T., Iimura, A., Nakamura, Y., Meroni, P., Nicoletti, F. Eur. J. Pharmacol. (2002) [Pubmed]
  15. Experimental allergic orchitis in mice. VI. Recombinations within the H-2S/H-2D interval define the map position of the H-2-associated locus controlling disease susceptibility. Teuscher, C., Gasser, D.L., Woodward, S.R., Hickey, W.F. Immunogenetics (1990) [Pubmed]
  16. Partial inhibition of cell-mediated immunity (CMI) by niridazole: effect upon development of autoimmune aspermatogenic orchitis (AIAO) in guinea pigs. Nemirovsky, M.S. American journal of reproductive immunology : AJRI : official journal of the American Society for the Immunology of Reproduction and the International Coordination Committee for Immunology of Reproduction. (1982) [Pubmed]
  17. Characterization of signaling pathways leading to Fas expression induced by TNF-alpha: pivotal role of NF-kappaB. Starace, D., Riccioli, A., D'Alessio, A., Giampietri, C., Petrungaro, S., Galli, R., Filippini, A., Ziparo, E., De Cesaris, P. FASEB J. (2005) [Pubmed]
  18. The immunogenetics of susceptibility and resistance to murine experimental allergic orchitis. Person, P.L., Snoek, M., Demant, P., Woodward, S.R., Teuscher, C. Regional immunology. (1992) [Pubmed]
  19. Immune complex orchitis in infertile men. Immunoelectron microscopy of abnormal basement membrane structures. Salomon, F., Saremaslani, P., Jakob, M., Hedinger, C.E. Lab. Invest. (1982) [Pubmed]
  20. Mumps orchitis among soldiers: frequency, effect on sperm quality, and sperm antibodies. Shulman, A., Shohat, B., Gillis, D., Yavetz, H., Homonnai, Z.T., Paz, G. Fertil. Steril. (1992) [Pubmed]
  21. Correlation between inhibin secretion and damage of seminiferous tubules in a model of experimental autoimmune orchitis. Suescun, M.O., Suescun, M.O., Lustig, L., Calandra, R.S., Calandra, R.S., Groome, N.P., Campo, S. J. Endocrinol. (2001) [Pubmed]
  22. Expression and regulation of the CXC-chemokines, GRO/KC and IP-10/mob-1 in rat seminiferous tubules. Aubry, F., Habasque, C., Satie, A.P., Jégou, B., Samson, M. Eur. Cytokine Netw. (2000) [Pubmed]
  23. Monocyte chemoattractant protein-1 (MCP-1/CCL2) in experimental autoimmune orchitis. Guazzone, V.A., Rival, C., Denduchis, B., Lustig, L. J. Reprod. Immunol. (2003) [Pubmed]
  24. Three Hsp70 genes are located in the C4-H-2D region: possible candidates for the Orch-1 locus. Snoek, M., Jansen, M., Olavesen, M.G., Campbell, R.D., Teuscher, C., van Vugt, H. Genomics (1993) [Pubmed]
  25. Essential pathogenic role for endogenous interferon-gamma (IFN-gamma) during disease onset phase of murine experimental autoimmune orchitis. I. In vivo studies. Itoh, M., Yano, A., Xie, Q., Iwahashi, K., Takeuchi, Y., Meroni, P.L., Nicoletti, F. Clin. Exp. Immunol. (1998) [Pubmed]
  26. Observations on autoimmune orchitis in sterile mice carrying a recessive lethal mutation at the T/t complex exhibiting spontaneous allergic orchitis. Dooher, G.B., Artzt, K., Bennett, D., Hurtenbach, U. J. Reprod. Fertil. (1981) [Pubmed]
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