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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Continuous pump-driven hemofiltration associated with a decline in alpha-atrial natriuretic peptide.

The levels of alpha-atrial natriuretic peptide ( ANP) in the right atrium, pulmonary artery, radial artery, and superior vena cava plasma were measured by radioimmunoassay in eight patients with volume-expansion due to different diseases. The alpha- ANP levels were significantly increased, but became decreased after fluid removal by continuous veno-venous hemofiltration. When all alpha- ANP concentrations of different anatomical locations and hemodynamic variables were grouped, pulmonary capillary wedge pressure correlated significantly with all alpha- ANP groups, whereas right atrial mean pressure correlated with alpha- ANP levels in pulmonary artery plasma only. Alpha- ANP concentrations were distinctly lower in superior vena cava plasma than in plasma from the right atrium, pulmonary artery, and radial artery. Since alpha- ANP plays an important role in the homeostasis of sodium and fluid balance, measurement of alpha- ANP concentrations, particularly in right atrium, pulmonary artery, or radial artery plasma, might provide valuable information on the status of the critically ill.[1]


  1. Continuous pump-driven hemofiltration associated with a decline in alpha-atrial natriuretic peptide. Pacher, R., Frass, M., Hartter, E., Woloszczuk, W., Leithner, C. Crit. Care Med. (1986) [Pubmed]
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