The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)



Gene Review

CA5A  -  carbonic anhydrase VA, mitochondrial

Homo sapiens

Synonyms: CA-VA, CA5, CA5AD, CAV, CAVA, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of CA5A


Psychiatry related information on CA5A

  • CONCLUSIONS: These wide range differences and confidence limits would lead to large errors if superior vena cava or right atrial oxyhemoglobin saturations were substituted for true mixed venous blood in oxygen transport or pulmonary venous admixture calculations, or if clinical decision making was based on individual results [6].
  • The first patient CAV, studied and described in the literature by Warrington in 1981, presented with unusual concrete word dyslexia, i.e., he had a category-specific reading deficit for concrete words compared with abstract words [7].
  • The rats with hyperdipsia induced by lesion of the SA drank more water than either normal rats or SFO-lesioned animals under the same thirst-eliciting or angiotensin-liberating stimuli (polyethyleneglycol, isoproterenol, water deprivation and ligation of the inferior vena cava) [8].
  • MR has a problem-solving role, and conventional venography is now limited to specific scenarios including evaluation of central DVT in the upper extremities, as a prelude to intervention for thrombolysis/thrombectomy, and prior to placement of an inferior vena cava filter [9].

High impact information on CA5A


Chemical compound and disease context of CA5A


Biological context of CA5A

  • FISH analysis allowed CA5 to be assigned to chromosome 16q24 [19].
  • CA5 also contains a 12-bp GT-rich segment beginning 13 bp downstream of the polyadenylation signal in the 3' untranslated region of exon 7 [19].
  • The CA V gene (CA5) is approximately 50 kb long and contains 7 exons and 6 introns [19].
  • Like the CA VII gene, CA5 does not contain typical TATA and CAAT promoter elements in the 5' flanking region but does contain a TTTAA sequence 147 nucleotides upstream of the initiation codon [19].
  • I suggest that a Valsalva manoeuvre, blocking venous return through the superior vena cava, may allow brief retrograde transmission of high venous pressure from the arms to the cerebral venous system, resulting in venous ischaemia to the diencephalon or mesial temporal lobes and to TGA [20].

Anatomical context of CA5A

  • IL-1-induced cGMP was also NO independent in human umbilical artery VSMC, and NO dependent in rat vena cava VSMC [21].
  • Monoclonal B2.12, but not B59.2, binds to cultured human endothelial cells obtained from umbilical vein, internal iliac artery, and inferior vena cava [22].
  • Furthermore, experimental connection of the common bile duct to the vena cava is followed after a few hours by the appearance of LP-X-like material in the plasma [23].
  • The catheter introduced into the inferior vena cava opacified a large opening of this shunt below the right and left hepatic vein openings [24].
  • Postmortem examination showed myxoid intimal proliferation involving the hepatic, portal and femoral veins, and the inferior vena cava at the level of the stenosis [25].

Associations of CA5A with chemical compounds

  • Between September, 1992, and August, 1995, 339 patients were randomly allocated four cycles of 50 mg oral etoposide twice daily for 10 days (171 patients) or a standard intravenous regimen of etoposide and vincristine (EV), or cyclophosphamide, doxorubicin, and vincristine (CAV, 168 controls) [26].
  • In patients receiving a 100-micrograms bolus and a 100-micrograms/h infusion, heart rate, cardiac index, and systemic vascular resistance showed no significant changes, whereas right atrial pressure, pulmonary capillary wedge pressure, and inferior vena cava pressure decreased significantly after octreotide infusion compared with basal values [27].
  • We showed, with use of fluorescein retinal angiography, that during retrograde cerebral perfusion, fluorescein injected into the superior vena cava entered the retinal venules, flowed to the capillaries, and subsequently, to the retinal arterioles [28].
  • Vasodepressor reaction induced by inferior vena cava occlusion and isoproterenol in the rat. Role of beta 1- and beta 2-adrenergic receptors [29].
  • Preload was transiently reduced by 30% using balloon occlusion of the inferior vena cava, and afterload impedance was lowered by 50%, induced by a bolus injection of nitroglycerin [30].

Other interactions of CA5A

  • Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p [19].
  • Similar to CA VA, CA VB is a "low activity" enzyme with a sensitivity to acetazolamide [31].
  • Kinetic parameters proved it to be 3.37 times more effective than hCA VA as a catalyst for the physiological reaction, with kcat = 9.5 x 10(5) s(-1) and kcat/K(M) = 9.8 x 10(7) M(-1) s(-1), being second only to hCA II among the 16 isoforms presently known in humans [32].

Analytical, diagnostic and therapeutic context of CA5A


  1. Case 3-1981: leiomyosarcoma of inferior vena cava. Cantwell, B. N. Engl. J. Med. (1981) [Pubmed]
  2. Letter: Thrombosis of the renal veins and vena cava. Cohen, A.H. JAMA (1976) [Pubmed]
  3. Superior vena cava obstruction and dissecting aortic aneurysm. Spitzer, S., Blanco, G., Adam, A., Spyrou, P.G., Mason, D. JAMA (1975) [Pubmed]
  4. Massive dilation of the inferior vena cava. Association with tricuspid regurgitation. Dutta, S.K., Plotnick, G.D., Williams, R., Morris, F. JAMA (1978) [Pubmed]
  5. Fatal cardiac tamponade. Occurrence with other complications after left internal jugular vein catheterization. Sheep, R.E., Guiney, W.B. JAMA (1982) [Pubmed]
  6. Importance of the sampling site for measurement of mixed venous oxygen saturation in shock. Edwards, J.D., Mayall, R.M. Crit. Care Med. (1998) [Pubmed]
  7. Impaired oral reading in two atypical dyslexics: a comparison with a computational lexical-analogy model. Marchand, Y., Friedman, R.B. Brain and language. (2005) [Pubmed]
  8. Influence of the subfornical organ on water intake induced by septal lesion. Saad, W.A., de Arruda Camargo, L.A., Morita, N., Antunes-Rodrigues, J., Covian, M.R. Acta physiologica latino americana. (1979) [Pubmed]
  9. Current DVT imaging. Katz, D.S., Hon, M. Techniques in vascular and interventional radiology. (2004) [Pubmed]
  10. Images in clinical medicine. Renal-cell carcinoma extending into the vena cava and right side of the heart. Hunsaker, R.P., Stone, J.R. N. Engl. J. Med. (2001) [Pubmed]
  11. The transjugular intrahepatic portosystemic stent-shunt procedure for refractory ascites. Ochs, A., Rössle, M., Haag, K., Hauenstein, K.H., Deibert, P., Siegerstetter, V., Huonker, M., Langer, M., Blum, H.E. N. Engl. J. Med. (1995) [Pubmed]
  12. Cardiothoracic emergencies associated with subclavian hemodialysis catheters. Barton, B.R., Hermann, G., Weil, R. JAMA (1983) [Pubmed]
  13. Inferior vena cava obstruction in Whipple disease. Association with retroperitoneal lymphadenopathy. Maas, L.C., Liu, H., Gelzayd, E.A. JAMA (1976) [Pubmed]
  14. Thrombosis of the renal veins and vena cava. Occurrence in morbid obesity. Luft, F.C., Walker, P.D., Hamburger, R.J., Kleit, S.A. JAMA (1975) [Pubmed]
  15. The diagnosis of primary hyperaldosteronism. Vaughan, N.J., Jowett, T.P., Slater, J.D., Wiggins, R.C., Lightman, S.L., Ma, J.T., Payne, N.N. Lancet (1981) [Pubmed]
  16. Role of adenosine receptors in the paradoxic bradycardia response of rats to inferior vena cava occlusion during an infusion of isoproterenol. Waxman, M.B., Asta, J.A. Circulation (1998) [Pubmed]
  17. Treatment of limited-stage small-cell lung cancer with cyclophosphamide, doxorubicin, and vincristine with or without etoposide: a randomized trial of the North Central Cancer Treatment Group. Jett, J.R., Everson, L., Therneau, T.M., Krook, J.E., Dalton, R.J., Marschke, R.F., Veeder, M.H., Brunk, S.F., Mailliard, J.A., Twito, D.I. J. Clin. Oncol. (1990) [Pubmed]
  18. Intensive weekly chemotherapy for the treatment of extensive-stage small-cell lung cancer. Murray, N., Shah, A., Osoba, D., Page, R., Karsai, H., Grafton, C., Goddard, K., Fairey, R., Voss, N. J. Clin. Oncol. (1991) [Pubmed]
  19. Genomic organization of the human gene (CA5) and pseudogene for mitochondrial carbonic anhydrase V and their localization to chromosomes 16q and 16p. Nagao, Y., Batanian, J.R., Clemente, M.F., Sly, W.S. Genomics (1995) [Pubmed]
  20. Aetiology of transient global amnesia. Lewis, S.L. Lancet (1998) [Pubmed]
  21. Interleukin 1 activates soluble guanylate cyclase in human vascular smooth muscle cells through a novel nitric oxide-independent pathway. Beasley, D., McGuiggin, M. J. Exp. Med. (1994) [Pubmed]
  22. A monoclonal antibody to human platelet glycoprotein IIIa detects a related protein in cultured human endothelial cells. Thiagarajan, P., Shapiro, S.S., Levine, E., DeMarco, L., Yalcin, A. J. Clin. Invest. (1985) [Pubmed]
  23. Formation of lipoprotein-X. Its relationship to bile compounds. Manzato, E., Fellin, R., Baggio, G., Walch, S., Neubeck, W., Seidel, D. J. Clin. Invest. (1976) [Pubmed]
  24. An unusual portal-systemic shunt, most likely through a patent ductus venosus. A case report. Ohnishi, K., Hatano, H., Nakayama, T., Kohno, K., Okuda, K. Gastroenterology (1983) [Pubmed]
  25. Inferior vena cava stenosis and Budd--Chiari syndrome in a woman taking oral contraceptives. Lalonde, G., Théoret, G., Daloze, P., Bettez, P., Katz, S.S. Gastroenterology (1982) [Pubmed]
  26. Comparison of oral etoposide and standard intravenous multidrug chemotherapy for small-cell lung cancer: a stopped multicentre randomised trial. Medical Research Council Lung Cancer Working Party. Girling, D.J. Lancet (1996) [Pubmed]
  27. Hemodynamic evaluation of octreotide in patients with hepatitis B-related cirrhosis. Lin, H.C., Tsai, Y.T., Lee, F.Y., Lee, S.D., Hsia, H.C., Lin, W.J., Lo, K.J. Gastroenterology (1992) [Pubmed]
  28. Retrograde cerebral perfusion in human brains. Ono, T., Okita, Y., Ando, M., Kitamura, S. Lancet (2000) [Pubmed]
  29. Vasodepressor reaction induced by inferior vena cava occlusion and isoproterenol in the rat. Role of beta 1- and beta 2-adrenergic receptors. Waxman, M.B., Asta, J.A., Cameron, D.A. Circulation (1994) [Pubmed]
  30. Ventricular systolic assessment in patients with dilated cardiomyopathy by preload-adjusted maximal power. Validation and noninvasive application. Sharir, T., Feldman, M.D., Haber, H., Feldman, A.M., Marmor, A., Becker, L.C., Kass, D.A. Circulation (1994) [Pubmed]
  31. Human mitochondrial carbonic anhydrase VB. cDNA cloning, mRNA expression, subcellular localization, and mapping to chromosome x. Fujikawa-Adachi, K., Nishimori, I., Taguchi, T., Onishi, S. J. Biol. Chem. (1999) [Pubmed]
  32. Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors. Nishimori, I., Vullo, D., Innocenti, A., Scozzafava, A., Mastrolorenzo, A., Supuran, C.T. J. Med. Chem. (2005) [Pubmed]
  33. Therapeutic balloon occlusion of the inferior vena cava. Hunter, J.A., Sessions, R., Petasnick, J. JAMA (1975) [Pubmed]
  34. Marked hepatic congestion caused by a thoracoabdominal aneurysm. Sigal, E., Pogany, A., Goldman, I.S. Gastroenterology (1984) [Pubmed]
  35. Metastatic Wilms' tumor causing acute hepatic-vein occlusion (Budd-Chiari syndrome). Schraut, W.H., Chilcote, R.R. Gastroenterology (1985) [Pubmed]
  36. Diagnosis of Budd-Chiari syndrome by pulsed Doppler ultrasound. Bolondi, L., Gaiani, S., Li Bassi, S., Zironi, G., Bonino, F., Brunetto, M., Barbara, L. Gastroenterology (1991) [Pubmed]
WikiGenes - Universities