Disease relevance of Hemofiltration

• Hemofiltration for digoxin toxicity [1].
• METHODS: Nine critically ill anuric patients with acute renal failure undergoing continuous venovenous hemofiltration received 500 mg meropenem 2 or 3 times daily [2].
• Arginine vasopressin (AVP) was measured in the plasma and its ultrafiltrate in 11 patients with end-stage renal failure treated by hemofiltration [3].
• Regional citrate anticoagulation in continuous venovenous hemofiltration in critically ill patients with a high risk of bleeding [4].
• As can be anticipated from the animal experiments, the efficiency of plasmapheresis or hemofiltration methods may be improved by previous application of large doses of hTBPA or hTBG in cases of thyrotoxicosis [5].

High impact information on Hemofiltration

• Postdilution hemofiltration and continuous arteriovenous hemofiltration with oral D-penicillamine allowed removal of a total of 95,700 micrograms of copper; 78,665 micrograms of the total were removed via postdilution hemofiltration alone [6].
• Removal of toxic levels of N-acetylprocainamide with continuous arteriovenous hemofiltration or continuous arteriovenous hemodiafiltration [7].
• Continuous arteriovenous hemofiltration is an extracorporeal technique for the treatment of fluid overload and electrolyte disturbances and for the removal of urea nitrogen [8].
• Phase I study of hepatic arterial melphalan infusion and hepatic venous hemofiltration using percutaneously placed catheters in patients with unresectable hepatic malignancies [9].
• PURPOSE: We conducted a phase I study of a 30-minute hepatic artery infusion of melphalan via a percutaneously placed catheter and hepatic venous hemofiltration using a double balloon catheter positioned in the retrohepatic inferior vena cava to shunt hepatic venous effluent through an activated charcoal filter and then to the systemic circulation [9].

Chemical compound and disease context of Hemofiltration

• Continuous venovenous hemofiltration with dialysis and lactate clearance in critically ill patients [10].
• Although uric acid, inorganic phosphate, creatinine, potassium, guanidinoacetic acid, and methylguanidine are intracellular substances, they accumulated also in the extracellular fluid in renal failure, and were removed from both compartments, intracellular as well as extracellular, by hemofiltration [11].
• Removal of piperacillin in critically ill patients undergoing continuous venovenous hemofiltration [12].
• Mild hyperventilation, perioperative hemofiltration, and N-acetylcysteine infusion were used according to our clinical practice [13].
• The objective of the study was to investigate whether continuous venovenous hemofiltration (CVVH) would facilitate removal of substantial amounts of tumor necrosis factor (TNF) and interleukin-6 (IL-6) from the circulation in traumatized critically ill patients with multiple organ dysfunction syndrome [14].

Biological context of Hemofiltration

• Single-dose pharmacokinetics of meropenem during continuous venovenous hemofiltration [15].
• Ultrafiltrate, obtained during a hemofiltration session, inhibited protein binding of theophylline and phenytoin in a dose dependent way [16].
• SECONDARY OUTCOMES: Mean (SE) reduction in platelet count during hemofiltration was 63 (25.8) x 10(9) for heparin and 41.8 (26.6) x 10(9) for dalteparin (p = .57, unpaired Student's t-test) [17].
• Effect of prostacyclin on platelets, polymorphonuclear cells, and heterotypic cell aggregation during hemofiltration [18].
• The impact of lactate-buffered high-volume hemofiltration on acid-base balance [19].

Anatomical context of Hemofiltration

• Removal, generation and adsorption of beta-2-microglobulin during hemofiltration with five different membranes [20].
• Most patients received coagulation active treatment (fresh-frozen plasma, thrombocyte concentrates, coagulation factors, and continuous veno-venous hemofiltration with heparin) [21].
• It did not appear to depend on variations in parameters related to the sympathetic activity, such as plasma renin, right atrial, wedge pulmonary artery and renal perfusion pressures, and was independent of duration and amount of hemofiltration [22].
• In conclusion, as a supplemented physiological saline solution may have detrimental effects on the condition of the hepatocytes, the more complex hemofiltration solution (bicarbonate buffered, glucose, essential minerals) was considered the better alternative for flushing bioartificial liver systems [23].

Associations of Hemofiltration with chemical compounds

• Low-molecular-weight heparin for anticoagulation during continuous venovenous hemofiltration [24].
• The fasting hyperglucagonemia did not decrease after hemofiltration but exhibited normal suppression with IV glucose [25].
• Hemofiltration in digoxin overdose [26].
• In this review we compare the effectiveness of lithium removal by various dialysis methods, including bicarbonate dialysis, peritoneal dialysis and continuous arteriovenous hemofiltration [27].
• Prazosin was used to test the acute response to changes in atrial receptors and hemofiltration to test the response to changes in volume receptors [28].

Gene context of Hemofiltration

• Pre-filter (afferent), post-filter (efferent) and ultrafiltrate concentrations of cytokines (IL-1 beta, IL-6, IL-8, TNF alpha) and of complement components (C3, C3adesArg, C5adesArg, terminal complement complex) were measured after the beginning of hemofiltration (t0), and 60 minutes later (t60) [29].
• In conclusion, the reduction in TNF-alpha, IL-6 and IL-8 was most impressive with the polyacrylonitrile membrane after 4 h of hemofiltration and was largely due to adsorption [30].
• The median sieving coefficient (SC) for all membranes was 0.0 for TNF-alpha, below 0.15 for IL-6 and below 0.15 for IL-8 during postdilution hemofiltration [30].
• Hemofiltered patients showed higher TM plasma levels, which further increased during the hemofiltration procedure [31].
• Interleukin-1 (IL-1) increased slowly at the end of CPB and hemofiltration had no effect [32].

Analytical, diagnostic and therapeutic context of Hemofiltration

• The aim of this study was to assess pharmacokinetic data of meropenem in patients with acute renal failure and to determine the amount of drug removed by continuous venovenous hemofiltration, an often-used renal replacement therapy in patients with acute renal failure [2].
• We conclude that LMW heparin is a suitable alternative to standard UF heparin for anticoagulation in hemodialysis/hemofiltration therapy [33].
• The amount of capted beta 2m was more elevated in hemodialyzed patients than in patients treated by hemofiltration or CAPD, in whom it could reach 5 mg/kg/day [34].
• Is low-molecular-weight heparin useful for venovenous hemofiltration in the intensive care unit [35]?
• When the ultrafiltration flow rate was low, the amount of phenytoin removed by hemofiltration was small relative to the usual daily dose [36].

References