Hypophysectomized male rats treated with polydimethylsiloxane capsules containing testosterone: effects on spermatogenesis, fertility, and reproductive tract concentrations of androgens.
Spermatogenesis, reproductive luminal contents and androgen concentrations were examined in hypophysectomized male rats treated with 1 of 3 testosterone (T) dosages for 60-64 days and in sham-operated controls. Hypophysectomized rats treated with 2 cm long T implants showed normal mating but reduced fertility, while normal fertility was maintained in animals given 8 or 3 x 8 cm T. Spermatogenesis in the hypophysectomized groups treated with 2 cm T for 10 days was generally arrested at the spermatocyte stage, while in the hypophysectomized animals treated with 2 cm T for 64 days spermatogenesis was halted at the spermatid stage. The 8 and 3 x 8 T-treated hypophysectomized animals had normal spermatogenesis with only minimal focal areas of degenerating seminiferous epithelium. Serum T concentrations were reduced by hypophysectomy, maintained at control levels by the 2 cm T dosage and increased to pharmacological levels in a dose-dependent manner by 8 and 3 x 8 cm T treatments. Testicular T concentrations also responded in a dose-dependent manner but the 3 x 8 cm T dose was not sufficient to keep testicular T at control levels. Dihydrotestosterone (DHT) in the caput epididymidis was maintained at control levels by the 8, reduced by the 2 and elevated by the 3 x 8 cm T treatment. Without gonadotropins, higher than normal levels of serum T are required to maintain normal fertility, although this normal reproductive capacity is possible even with greatly reduced testicular T concentrations.[1]References
- Hypophysectomized male rats treated with polydimethylsiloxane capsules containing testosterone: effects on spermatogenesis, fertility, and reproductive tract concentrations of androgens. Buhl, A.E., Cornette, J.C., Kirton, K.T., Yuan, Y.D. Biol. Reprod. (1982) [Pubmed]
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