The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Transgenic mice over-expressing the human spermidine synthase gene.

We have generated a transgenic mouse line harbouring the functional (chromosome-1-derived) human spermidine synthase (EC gene in their genome. The transgenic animals expressed the human gene-derived mRNA, as revealed by reverse-transcriptase/PCR analysis, in all tissues studied and displayed tissue spermidine synthase activity that was 2-6 times that in their syngenic littermates. The elevated spermidine synthase activity, however, had virtually no effect on tissue putrescine, spermidine or spermine levels. The view that the accumulation of spermidine and spermine is possibly controlled by S-adenosylmethionine decarboxylase was further supported by the finding that tissue spermidine and spermine contents also remained practically normal in hybrid transgenic mice over- expressing both human ornithine decarboxylase and spermidine synthase genes.[1]


  1. Transgenic mice over-expressing the human spermidine synthase gene. Kauppinen, L., Myöhänen, S., Halmekytö, M., Alhonen, L., Jänne, J. Biochem. J. (1993) [Pubmed]
WikiGenes - Universities