Human carcinoembryonic antigen and biliary glycoprotein can serve as mouse hepatitis virus receptors.
Receptors for murine coronavirus mouse hepatitis virus (MHV) are members of the murine carcinoembryonic antigen ( CEA) gene family. Since MHV can also infect primates and cause central nervous system lesions (G. F. Cabirac et al., Microb. Pathog. 16:349-357, 1994; R. S. Murray et al., Virology 188:274-284, 1992), we examined whether human CEA-related molecules can be used by MHV as potential receptors. Transfection of plasmids expressing human carcinoembryonic antigen ( hCEA) and human biliary glycoprotein into COS-7 cells, which lack a functional MHV receptor, conferred susceptibility to two MHV strains, A59 and MHV-2. Domain exchange experiments between human and murine CEA-related molecules identified the immunoglobulin-like loop I of hCEA as the region conferring the virus-binding specificity. This finding expands the potential MHV receptors to primate species.[1]References
- Human carcinoembryonic antigen and biliary glycoprotein can serve as mouse hepatitis virus receptors. Chen, D.S., Asanaka, M., Chen, F.S., Shively, J.E., Lai, M.M. J. Virol. (1997) [Pubmed]
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