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Gene Review

CEACAM1  -  carcinoembryonic antigen-related cell...

Homo sapiens

Synonyms: BGP, BGP-1, BGP1, BGPI, Biliary glycoprotein 1, ...
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Disease relevance of CEACAM1


Psychiatry related information on CEACAM1

  • The fuzzy-coat localization of BGP implies a role in nonspecific defense mechanisms against pathogens [6].
  • Secondary efficacy criteria were SCAG, the BGP nursing rating, and, as psychometric variables, tests from the Nuremberg Psychogeriatric Inventory (NAI) [7].

High impact information on CEACAM1


Chemical compound and disease context of CEACAM1


Biological context of CEACAM1


Anatomical context of CEACAM1


Associations of CEACAM1 with chemical compounds

  • CEACAM1 and CEACAM3 each contain proteinaceous transmembrane and cytoplasmic domains; however, the processes of neisserial uptake mediated by these receptors differ with respect to their susceptibilities to both tyrosine kinase inhibitors and the actin microfilament-disrupting agent cytochalasin D [20].
  • For this purpose, we performed immunohistochemistry using the 4D1/C2 monoclonal antibody which specifically recognizes CEACAM1 and does not interact with other members of the CEA family [3].
  • Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen [21].
  • The difference in the kinetics of induction and effect of cycloheximide on CEA and BGP mRNAs suggest that the two genes are regulated differently in the same cell line [22].
  • We show that BGP-specific mAb which recognize an AB-domain epitope strongly augment adhesion to fibrinogen by an Fc receptor- and beta2 integrin-dependent mechanism [23].
  • Upon TCR ligation, the co-engaged CEACAM1 becomes phosphorylated on tyrosine residues within the ITIMs apparent in the cytoplasmic domain [24].

Physical interactions of CEACAM1

  • In this study we demonstrate that CEACAM1 interacts with CEACAM5, but not with CEACAM6 [18].
  • The CEACAM1/CEACAM8 complex in human cells might accordingly play a similar role as CEACAM1-L/CEACAM1-S dimers known to occur in rat cells [17].
  • As Lex groups on CEACAM1 are selectively attached and specifically interact with DC-SIGN, our findings suggest that CEACAM1 participates in immune regulation in physiological conditions and in pathological conditions, such as inflammation, autoimmune disease, and cancer [25].
  • CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration [26].

Co-localisations of CEACAM1


Regulatory relationships of CEACAM1

  • In the present study, human B cells were activated by interleukin-2 to express CEACAM1 and then stimulated to secrete antibodies and simultaneously coincubated with Opa- and OpaI GC of strain MS11 [2].
  • Taken together these findings suggest that CRH inhibits trophoblast invasion by decreasing the expression of CEACAM1 through CRHR1, an effect that might be involved in the pathophysiology of clinical conditions, such as preeclampsia and placenta accreta [28].
  • These data suggest that the epithelial down-regulation of CEACAM1 induces angiogenesis via increased expression of VEGF-C and VEGF-D [29].
  • Supernatant of CEACAM1-overexpressing DU-145 suppressed but that of CEACAM1-silenced increased the VEGF-induced endothelial tubes [30].
  • Various studies have suggested a link between CEACAM1 and cellular apoptosis, including a recent demonstration that ERK1/2 signaling is triggered downstream of CEACAM1 [31].

Other interactions of CEACAM1

  • The BGP I-specific domain, designated A', was 56.7% and 55.8% identical at the nucleotide level and 42.6% and 39.6% identical at the amino acid level to the immunoglobulin-like domain of NCA and the first immunoglobulin-like domain of CEA, respectively [21].
  • We examined the role of phosphatidylinositol 3-kinases (PI3Ks) in gonococcal invasion of epithelial cell lines expressing either CEACAM1 or CEACAM3 [32].
  • In contrast to previous findings on normal and cancerous colonic tissues, the transcripts of CGM2 were totally undetectable and those of BGP were recognized only marginally, if at all, in normal gastric mucosa, while both messages were detected at significant levels in most of the gastric adenocarcinomas [33].
  • Polymerase chain reaction analysis of the four alternatively spliced transcripts of BGP revealed no differential induction of one transcript over another by IFN-gamma [22].
  • The structural features surrounding the tyrosine residues in the cytoplasmic domain of BGP share similarity with the consensus sequence of the immunoreceptor tyrosine-based inhibition motif (ITIM), the docking site for SHIP, SHP-1, and SHP-2 molecules [34].

Analytical, diagnostic and therapeutic context of CEACAM1

  • Proteins were analyzed by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE), blotting and immunochemical staining with anti-carcinoembryonic antigen, CEA-related adhesion molecule 1 (CEACAM1) cross-reacting antibodies [35].
  • Immunoblotting analysis revealed that the TEC-11 epitope was present in all cell types expressing CEACAM1 containing the A2 domain [CEACAM1(A2)], including granulocytes (160 000 MW isoform) and sperm cells (140 000 MW isoform) [36].
  • The specific localization to extravillous trophoblast and its expression pattern in gestational trophoblastic lesions indicate that CEACAM1 can potentially be a helpful additional diagnostic marker in the differential diagnosis of such lesions [3].
  • Using confocal laser scanning microscopy, we observed a marked recruitment of CD66 antigen by Opa52-expressing gonococci on both the transfected cell lines and infected PMNs [37].
  • Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues [38].


  1. cis-Determinants in the cytoplasmic domain of CEACAM1 responsible for its tumor inhibitory function. Izzi, L., Turbide, C., Houde, C., Kunath, T., Beauchemin, N. Oncogene (1999) [Pubmed]
  2. Neisseria gonorrhoeae kills carcinoembryonic antigen-related cellular adhesion molecule 1 (CD66a)-expressing human B cells and inhibits antibody production. Pantelic, M., Kim, Y.J., Bolland, S., Chen, I., Shively, J., Chen, T. Infect. Immun. (2005) [Pubmed]
  3. Expression pattern of the adhesion molecule CEACAM1 (C-CAM, CD66a, BGP) in gestational trophoblastic lesions. Bamberger, A.M., Sudahl, S., Wagener, C., Löning, T. Int. J. Gynecol. Pathol. (2001) [Pubmed]
  4. Down-regulation of carcinoembryonic antigen family member 2 expression is an early event in colorectal tumorigenesis. Thompson, J., Seitz, M., Chastre, E., Ditter, M., Aldrian, C., Gespach, C., Zimmermann, W. Cancer Res. (1997) [Pubmed]
  5. The carboxyl-terminal region of biliary glycoprotein controls its tyrosine phosphorylation and association with protein-tyrosine phosphatases SHP-1 and SHP-2 in epithelial cells. Huber, M., Izzi, L., Grondin, P., Houde, C., Kunath, T., Veillette, A., Beauchemin, N. J. Biol. Chem. (1999) [Pubmed]
  6. Cell- and region-specific expression of biliary glycoprotein and its messenger RNA in normal human colonic mucosa. Frängsmyr, L., Baranov, V., Prall, F., Yeung, M.M., Wagener, C., Hammarström, S. Cancer Res. (1995) [Pubmed]
  7. Efficacy of xantinolnicotinate in patients with dementia. Kanowski, S., Fischhof, P.K., Grobe-Einsler, R., Wagner, G., Litschauer, G. Pharmacopsychiatry (1990) [Pubmed]
  8. CEACAMs: their role in physiology and pathophysiology. Kuespert, K., Pils, S., Hauck, C.R. Curr. Opin. Cell Biol. (2006) [Pubmed]
  9. SHP1 Phosphatase-Dependent T Cell Inhibition by CEACAM1 Adhesion Molecule Isoforms. Nagaishi, T., Pao, L., Lin, S.H., Iijima, H., Kaser, A., Qiao, S.W., Chen, Z., Glickman, J., Najjar, S.M., Nakajima, A., Neel, B.G., Blumberg, R.S. Immunity (2006) [Pubmed]
  10. CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor. Ergün, S., Kilik, N., Ziegeler, G., Hansen, A., Nollau, P., Götze, J., Wurmbach, J.H., Horst, A., Weil, J., Fernando, M., Wagener, C. Mol. Cell (2000) [Pubmed]
  11. CEACAM1 in Cervical Cancer and Precursor Lesions: Association With Human Papillomavirus Infection. Albarran-Somoza, B., Franco-Topete, R., Delgado-Rizo, V., Cerda-Camacho, F., Acosta-Jimenez, L., Lopez-Botet, M., Daneri-Navarro, A. J. Histochem. Cytochem. (2006) [Pubmed]
  12. Retinoic acid treated HL60 cells express CEACAM1 (CD66a) and phagocytose Neisseria gonorrhoeae. Pantelic, M., Chen, I., Parker, J., Zhang, P., Grunert, F., Chen, T. FEMS Immunol. Med. Microbiol. (2004) [Pubmed]
  13. Expression of CEACAM1 in adenocarcinoma of the lung: a factor of independent prognostic significance. Laack, E., Nikbakht, H., Peters, A., Kugler, C., Jasiewicz, Y., Edler, L., Brümmer, J., Schumacher, U., Hossfeld, D.K. J. Clin. Oncol. (2002) [Pubmed]
  14. CEACAM1 enhances invasion and migration of melanocytic and melanoma cells. Ebrahimnejad, A., Streichert, T., Nollau, P., Horst, A.K., Wagener, C., Bamberger, A.M., Brümmer, J. Am. J. Pathol. (2004) [Pubmed]
  15. Activation-induced expression of carcinoembryonic antigen-cell adhesion molecule 1 regulates mouse T lymphocyte function. Nakajima, A., Iijima, H., Neurath, M.F., Nagaishi, T., Nieuwenhuis, E.E., Raychowdhury, R., Glickman, J., Blau, D.M., Russell, S., Holmes, K.V., Blumberg, R.S. J. Immunol. (2002) [Pubmed]
  16. Distinct mechanisms of internalization of Neisseria gonorrhoeae by members of the CEACAM receptor family involving Rac1- and Cdc42-dependent and -independent pathways. Billker, O., Popp, A., Brinkmann, V., Wenig, G., Schneider, J., Caron, E., Meyer, T.F. EMBO J. (2002) [Pubmed]
  17. Carcinoembryonic antigen-related cell adhesion molecule 1 expression and signaling in human, mouse, and rat leukocytes: evidence for replacement of the short cytoplasmic domain isoform by glycosylphosphatidylinositol-linked proteins in human leukocytes. Singer, B.B., Scheffrahn, I., Heymann, R., Sigmundsson, K., Kammerer, R., Obrink, B. J. Immunol. (2002) [Pubmed]
  18. The critical role of residues 43R and 44Q of carcinoembryonic antigen cell adhesion molecules-1 in the protection from killing by human NK cells. Markel, G., Gruda, R., Achdout, H., Katz, G., Nechama, M., Blumberg, R.S., Kammerer, R., Zimmermann, W., Mandelboim, O. J. Immunol. (2004) [Pubmed]
  19. Carcinoembryonic antigen family receptor specificity of Neisseria meningitidis Opa variants influences adherence to and invasion of proinflammatory cytokine-activated endothelial cells. Muenzner, P., Dehio, C., Fujiwara, T., Achtman, M., Meyer, T.F., Gray-Owen, S.D. Infect. Immun. (2000) [Pubmed]
  20. Engulfment of Neisseria gonorrhoeae: revealing distinct processes of bacterial entry by individual carcinoembryonic antigen-related cellular adhesion molecule family receptors. McCaw, S.E., Liao, E.H., Gray-Owen, S.D. Infect. Immun. (2004) [Pubmed]
  21. Molecular cloning of a cDNA coding biliary glycoprotein I: primary structure of a glycoprotein immunologically crossreactive with carcinoembryonic antigen. Hinoda, Y., Neumaier, M., Hefta, S.A., Drzeniek, Z., Wagener, C., Shively, L., Hefta, L.J., Shively, J.E., Paxton, R.J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  22. Differential regulation of carcinoembryonic antigen and biliary glycoprotein by gamma-interferon. Takahashi, H., Okai, Y., Paxton, R.J., Hefta, L.J., Shively, J.E. Cancer Res. (1993) [Pubmed]
  23. CD66: role in the regulation of neutrophil effector function. Stocks, S.C., Ruchaud-Sparagano, M.H., Kerr, M.A., Grunert, F., Haslett, C., Dransfield, I. Eur. J. Immunol. (1996) [Pubmed]
  24. CEACAM1 dynamics during neisseria gonorrhoeae suppression of CD4+ T lymphocyte activation. Lee, H.S., Ostrowski, M.A., Gray-Owen, S.D. J. Immunol. (2008) [Pubmed]
  25. CEACAM1, an adhesion molecule of human granulocytes, is fucosylated by fucosyltransferase IX and interacts with DC-SIGN of dendritic cells via Lewis x residues. Bogoevska, V., Horst, A., Klampe, B., Lucka, L., Wagener, C., Nollau, P. Glycobiology (2006) [Pubmed]
  26. CEACAM1 functionally interacts with filamin A and exerts a dual role in the regulation of cell migration. Klaile, E., Müller, M.M., Kannicht, C., Singer, B.B., Lucka, L. J. Cell. Sci. (2005) [Pubmed]
  27. CEACAM1, a cell-cell adhesion molecule, directly associates with annexin II in a three-dimensional model of mammary morphogenesis. Kirshner, J., Schumann, D., Shively, J.E. J. Biol. Chem. (2003) [Pubmed]
  28. Corticotropin-releasing hormone modulates human trophoblast invasion through carcinoembryonic antigen-related cell adhesion molecule-1 regulation. Bamberger, A.M., Minas, V., Kalantaridou, S.N., Radde, J., Sadeghian, H., Löning, T., Charalampopoulos, I., Brümmer, J., Wagener, C., Bamberger, C.M., Schulte, H.M., Chrousos, G.P., Makrigiannakis, A. Am. J. Pathol. (2006) [Pubmed]
  29. Dual role of carcinoembryonic antigen-related cell adhesion molecule 1 in angiogenesis and invasion of human urinary bladder cancer. Oliveira-Ferrer, L., Tilki, D., Ziegeler, G., Hauschild, J., Loges, S., Irmak, S., Kilic, E., Huland, H., Friedrich, M., Ergün, S. Cancer Res. (2004) [Pubmed]
  30. CEA-related cell adhesion molecule-1 is involved in angiogenic switch in prostate cancer. Tilki, D., Irmak, S., Oliveira-Ferrer, L., Hauschild, J., Miethe, K., Atakaya, H., Hammerer, P., Friedrich, M.G., Schuch, G., Galalae, R., Stief, C.G., Kilic, E., Huland, H., Ergun, S. Oncogene (2006) [Pubmed]
  31. CEACAM1 (CD66a) Promotes Human Monocyte Survival via a Phosphatidylinositol 3-Kinase- and AKT-dependent Pathway. Yu, Q., Chow, E.M., Wong, H., Gu, J., Mandelboim, O., Gray-Owen, S.D., Ostrowski, M.A. J. Biol. Chem. (2006) [Pubmed]
  32. Phosphatidylinositol 3-kinases in carcinoembryonic antigen-related cellular adhesion molecule-mediated internalization of Neisseria gonorrhoeae. Booth, J.W., Telio, D., Liao, E.H., McCaw, S.E., Matsuo, T., Grinstein, S., Gray-Owen, S.D. J. Biol. Chem. (2003) [Pubmed]
  33. Expression of four CEA family antigens (CEA, NCA, BGP and CGM2) in normal and cancerous gastric epithelial cells: up-regulation of BGP and CGM2 in carcinomas. Kinugasa, T., Kuroki, M., Takeo, H., Matsuo, Y., Ohshima, K., Yamashita, Y., Shirakusa, T., Matsuoka, Y. Int. J. Cancer (1998) [Pubmed]
  34. Biliary glycoprotein (BGPa, CD66a, CEACAM1) mediates inhibitory signals. Chen, T., Zimmermann, W., Parker, J., Chen, I., Maeda, A., Bolland, S. J. Leukoc. Biol. (2001) [Pubmed]
  35. Carcinoembryonic antigen-related cell adhesion molecule 1 is the 85-kilodalton pronase-resistant biliary glycoprotein in the cholesterol crystallization promoting low density protein-lipid complex. Jirsa, M., Muchová, L., Dráberová, L., Dráber, P., Smíd, F., Kuroki, M., Marecek, Z., Groen, A.K. Hepatology (2001) [Pubmed]
  36. Soluble isoforms of CEACAM1 containing the A2 domain: increased serum levels in patients with obstructive jaundice and differences in 3-fucosyl-N-acetyl-lactosamine moiety. Dráberová, L., Cerná, H., Brodská, H., Boubelík, M., Watt, S.M., Stanners, C.P., Dráber, P. Immunology (2000) [Pubmed]
  37. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes. Gray-Owen, S.D., Dehio, C., Haude, A., Grunert, F., Meyer, T.F. EMBO J. (1997) [Pubmed]
  38. Immunofluorescence studies on the occurrence and localization of the CEA-related biliary glycoprotein I (BGP I) in normal human gastrointestinal tissues. Svenberg, T., Hammarström, S., Zeromski, J. Clin. Exp. Immunol. (1979) [Pubmed]
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