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Gene Review

Ceacam1  -  carcinoembryonic antigen-related cell...

Mus musculus

Synonyms: BGP-1, Bgp, Bgp1, Bgpd, Biliary glycoprotein 1, ...
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Disease relevance of Ceacam1

  • When Bgp2-transfected hamster cells were challenged with MHV-A59, MHV-JHM, or MHV-3, the Bgp2-encoded protein served as a functional MHV receptor, although with a lower efficiency than that of the MHVR glycoprotein [1].
  • To investigate the interactions of these alternative MHVR glycoproteins with MHV, we expressed and purified to apparent homogeneity the extracellular domains of several murine Bgps as soluble, six-histidine-tagged glycoproteins, using a baculovirus expression system [2].
  • Very little mmCGM1 was detected in the mouse brain or in cells of the susceptible mouse astrocytoma cell line DBT [3].
  • We found that the three isoforms tested could serve as functional receptors for MHV-A59, although only isoforms that include the N-terminal domain of MHVR were recognized by monoclonal antibody CC1 in immunoblots or by MHV-A59 virions in virus overlay protein blot assays [4].
  • Mutational analysis of the virus and monoclonal antibody binding sites in MHVR, the cellular receptor of the murine coronavirus mouse hepatitis virus strain A59 [5].

Psychiatry related information on Ceacam1

  • To assess the role of receptors in the limited tissue tropism of enterotropic MHV strains, the permissiveness of MHVR- and mmCGM2-expressing cell lines and peritoneal exudate cells from BALB/c and SJL mice for MHV-RI and MHV-Y replication was determined [6].

High impact information on Ceacam1


Chemical compound and disease context of Ceacam1

  • GAG binding by B. burgdorferi is associated with haemagglutination and we have identified a 26 kDa protein, which we have termed Bgp (Borrelia GAG-binding protein), on the basis of its ability to bind to heparin and erythrocytes [11].
  • Androgen independent prostate cancer and its metastatic tumors generated in castrated TRAMP mice were also C-CAM negative [12].

Biological context of Ceacam1


Anatomical context of Ceacam1


Associations of Ceacam1 with chemical compounds

  • The soluble four-domain MHVR glycoprotein (sMHVR[1-4]) had fourfold more MHV-A59 neutralizing activity than the corresponding soluble Bgp1(b) (sBgp1(b)) glycoprotein and at least 1,000-fold more neutralizing activity than sBgp2 [2].
  • We recently demonstrated that C-CAM, an epithelial-cell adhesion molecule of the immunoglobulin supergene family, could be regulated by androgen and might act as a growth repressor during differentiation of the prostatic epithelium [17].
  • Nonglycosylated core MHVR proteins were made in Vac-MHVR-infected BHK-21 cells in the presence of tunicamycin by in vitro translation of MHVR mRNA in a rabbit reticulocyte cell-free system in the absence of microsomal membranes and by expression of an N-terminal deletion clone of MHVR lacking its signal peptide [18].
  • C-CAM produced dose-dependent rightward and slight downward shifts of the etonitazene dose-effect curve [19].
  • In addition, it was observed that higher doses of C-CAM were required to produce a shift down in the fentanyl dose-effect curve than were required to produce a shift down in the morphine dose-effect curve, which suggests that fentanyl is more efficacious than morphine [20].

Physical interactions of Ceacam1

  • In this investigation, peptides corresponding to the cytoplasmic domains of C-CAM were synthesized on cellulose membranes and used to map the binding sites for 125I-labeled calmodulin [21].

Regulatory relationships of Ceacam1

  • This suggests that calmodulin can regulate the functional activity of C-CAM [21].
  • To investigate the functional significance of SYNCRIP in MHV replication, we expressed a full-length or a C-terminally truncated form of SYNCRIP in mammalian cells expressing the MHV receptor [22].

Other interactions of Ceacam1


Analytical, diagnostic and therapeutic context of Ceacam1


  1. Bgp2, a new member of the carcinoembryonic antigen-related gene family, encodes an alternative receptor for mouse hepatitis viruses. Nédellec, P., Dveksler, G.S., Daniels, E., Turbide, C., Chow, B., Basile, A.A., Holmes, K.V., Beauchemin, N. J. Virol. (1994) [Pubmed]
  2. Purified, soluble recombinant mouse hepatitis virus receptor, Bgp1(b), and Bgp2 murine coronavirus receptors differ in mouse hepatitis virus binding and neutralizing activities. Zelus, B.D., Wessner, D.R., Williams, R.K., Pensiero, M.N., Phibbs, F.T., deSouza, M., Dveksler, G.S., Holmes, K.V. J. Virol. (1998) [Pubmed]
  3. Mouse hepatitis virus utilizes two carcinoembryonic antigens as alternative receptors. Yokomori, K., Lai, M.M. J. Virol. (1992) [Pubmed]
  4. Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59. Dveksler, G.S., Dieffenbach, C.W., Cardellichio, C.B., McCuaig, K., Pensiero, M.N., Jiang, G.S., Beauchemin, N., Holmes, K.V. J. Virol. (1993) [Pubmed]
  5. Mutational analysis of the virus and monoclonal antibody binding sites in MHVR, the cellular receptor of the murine coronavirus mouse hepatitis virus strain A59. Wessner, D.R., Shick, P.C., Lu, J.H., Cardellichio, C.B., Gagneten, S.E., Beauchemin, N., Holmes, K.V., Dveksler, G.S. J. Virol. (1998) [Pubmed]
  6. Enterotropic strains of mouse coronavirus differ in their use of murine carcinoembryonic antigen-related glycoprotein receptors. Compton, S.R. Virology (1994) [Pubmed]
  7. CEACAMs: their role in physiology and pathophysiology. Kuespert, K., Pils, S., Hauck, C.R. Curr. Opin. Cell Biol. (2006) [Pubmed]
  8. A pregnancy-specific glycoprotein is expressed in the brain and serves as a receptor for mouse hepatitis virus. Chen, D.S., Asanaka, M., Yokomori, K., Wang, F., Hwang, S.B., Li, H.P., Lai, M.M. Proc. Natl. Acad. Sci. U.S.A. (1995) [Pubmed]
  9. Mouse hepatitis virus strain A59 and blocking antireceptor monoclonal antibody bind to the N-terminal domain of cellular receptor. Dveksler, G.S., Pensiero, M.N., Dieffenbach, C.W., Cardellichio, C.B., Basile, A.A., Elia, P.E., Holmes, K.V. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  10. Receptor for mouse hepatitis virus is a member of the carcinoembryonic antigen family of glycoproteins. Williams, R.K., Jiang, G.S., Holmes, K.V. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  11. Identification of a candidate glycosaminoglycan-binding adhesin of the Lyme disease spirochete Borrelia burgdorferi. Parveen, N., Leong, J.M. Mol. Microbiol. (2000) [Pubmed]
  12. Differential expression of C-CAM cell adhesion molecule in prostate carcinogenesis in a transgenic mouse model. Pu, Y.S., Luo, W., Lu, H.H., Greenberg, N.M., Lin, S.H., Gingrich, J.R. J. Urol. (1999) [Pubmed]
  13. Differences in tissue-specific and embryonic expression of mouse Ceacam1 and Ceacam2 genes. Han, E., Phan, D., Lo, P., Poy, M.N., Behringer, R., Najjar, S.M., Lin, S.H. Biochem. J. (2001) [Pubmed]
  14. Characterization of a new gene that encodes a functional MHV receptor and progress in the identification of the virus-binding site(s). Dveksler, G., Nedellec, P., Lu, J.H., Keck, U., Basile, A., Cardellichio, C., Zimmermann, W., Beauchemin, N., Holmes, K.V. Adv. Exp. Med. Biol. (1995) [Pubmed]
  15. Targeted disruption of the Ceacam1 (MHVR) gene leads to reduced susceptibility of mice to mouse hepatitis virus infection. Blau, D.M., Turbide, C., Tremblay, M., Olson, M., Létourneau, S., Michaliszyn, E., Jothy, S., Holmes, K.V., Beauchemin, N. J. Virol. (2001) [Pubmed]
  16. Expression of the mouse hepatitis virus receptor by central nervous system microglia. Ramakrishna, C., Bergmann, C.C., Holmes, K.V., Stohlman, S.A. J. Virol. (2004) [Pubmed]
  17. Tumor suppressive role of an androgen-regulated epithelial cell adhesion molecule (C-CAM) in prostate carcinoma cell revealed by sense and antisense approaches. Hsieh, J.T., Luo, W., Song, W., Wang, Y., Kleinerman, D.I., Van, N.T., Lin, S.H. Cancer Res. (1995) [Pubmed]
  18. Binding of the coronavirus mouse hepatitis virus A59 to its receptor expressed from a recombinant vaccinia virus depends on posttranslational processing of the receptor glycoprotein. Pensiero, M.N., Dveksler, G.S., Cardellichio, C.B., Jiang, G.S., Elia, P.E., Dieffenbach, C.W., Holmes, K.V. J. Virol. (1992) [Pubmed]
  19. Irreversible opioid antagonist effects of clocinnamox on opioid analgesia and mu receptor binding in mice. Burke, T.F., Woods, J.H., Lewis, J.W., Medzihradsky, F. J. Pharmacol. Exp. Ther. (1994) [Pubmed]
  20. Clocinnamox: a novel, systemically-active, irreversible opioid antagonist. Comer, S.D., Burke, T.F., Lewis, J.W., Woods, J.H. J. Pharmacol. Exp. Ther. (1992) [Pubmed]
  21. Calmodulin binds to specific sequences in the cytoplasmic domain of C-CAM and down-regulates C-CAM self-association. Edlund, M., Blikstad, I., Obrink, B. J. Biol. Chem. (1996) [Pubmed]
  22. SYNCRIP, a member of the heterogeneous nuclear ribonucleoprotein family, is involved in mouse hepatitis virus RNA synthesis. Choi, K.S., Mizutani, A., Lai, M.M. J. Virol. (2004) [Pubmed]
  23. Cloning of the mouse hepatitis virus (MHV) receptor: expression in human and hamster cell lines confers susceptibility to MHV. Dveksler, G.S., Pensiero, M.N., Cardellichio, C.B., Williams, R.K., Jiang, G.S., Holmes, K.V., Dieffenbach, C.W. J. Virol. (1991) [Pubmed]
  24. Expression of interferon-gamma by a coronavirus defective-interfering RNA vector and its effect on viral replication, spread, and pathogenicity. Zhang, X., Hinton, D.R., Cua, D.J., Stohlman, S.A., Lai, M.M. Virology (1997) [Pubmed]
  25. Gene expression profiles in hypoxic preconditioning using cDNA microarray analysis: altered expression of an angiogenic factor, carcinoembryonic antigen-related cell adhesion molecule 1. Chen, W.J., Chen, H.W., Yu, S.L., Huang, C.H., Wang, T.D., Chen, J.J., Chien, C.T., Chen, H.Y., Yang, P.C., Lee, Y.T. Shock (2005) [Pubmed]
  26. Application of a tumor suppressor (C-CAM1)-expressing recombinant adenovirus in androgen-independent human prostate cancer therapy: a preclinical study. Kleinerman, D.I., Zhang, W.W., Lin, S.H., Nguyen, T.V., von Eschenbach, A.C., Hsieh, J.T. Cancer Res. (1995) [Pubmed]
  27. Consistent expression of an epithelial cell adhesion molecule (C-CAM) during human prostate development and loss of expression in prostate cancer: implication as a tumor suppressor. Kleinerman, D.I., Troncoso, P., Lin, S.H., Pisters, L.L., Sherwood, E.R., Brooks, T., von Eschenbach, A.C., Hsieh, J.T. Cancer Res. (1995) [Pubmed]
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