Gene Review:
Fgl2 - fibrinogen-like protein 2
Mus musculus
Synonyms:
AI385601, Cytotoxic T-lymphocyte-specific protein, Fiblp, Fibrinogen-like protein 2, Fibroleukin, ...
- The Fgl2/fibroleukin prothrombinase contributes to immunologically mediated thrombosis in experimental and human viral hepatitis. Marsden, P.A., Ning, Q., Fung, L.S., Luo, X., Chen, Y., Mendicino, M., Ghanekar, A., Scott, J.A., Miller, T., Chan, C.W., Chan, M.W., He, W., Gorczynski, R.M., Grant, D.R., Clark, D.A., Phillips, M.J., Levy, G.A. J. Clin. Invest. (2003)
- The emerging role of immunoregulation of fibrinogen-related procoagulant Fgl2 in the success or spontaneous abortion of early pregnancy in mice and humans. Clark, D.A., Ding, J.W., Chaouat, G., Coulam, C.B., August, C., Levy, G.A. Am. J. Reprod. Immunol. (1999)
- Association of mouse fibrinogen-like protein with murine hepatitis virus-induced prothrombinase activity. Parr, R.L., Fung, L., Reneker, J., Myers-Mason, N., Leibowitz, J.L., Levy, G. J. Virol. (1995)
- Fatal haemorrhage and incomplete block to embryogenesis in mice lacking coagulation factor V. Cui, J., O'Shea, K.S., Purkayastha, A., Saunders, T.L., Ginsburg, D. Nature (1996)
- Novel serine proteases encoded by two cytotoxic T lymphocyte-specific genes. Lobe, C.G., Finlay, B.B., Paranchych, W., Paetkau, V.H., Bleackley, R.C. Science (1986)
- Expression and T cell recognition of hybrid antigens with amino-terminal domains encoded by Qa-2 region of major histocompatibility complex and carboxyl termini of transplantation antigens. Stroynowski, I., Forman, J., Goodenow, R.S., Schiffer, S.G., McMillan, M., Sharrow, S.O., Sachs, D.H., Hood, L. J. Exp. Med. (1985)
- Murine lymphoid procoagulant activity induced by bacterial lipopolysaccharide and immune complexes is a monocyte prothrombinase. Schwartz, B.S., Levy, G.A., Fair, D.S., Edgington, T.S. J. Exp. Med. (1982)
- Effects of nutritional folate deficiency on the adhesive properties of murine melanoma cells. Branda, R.F., Tracy, P.B. Cancer Lett. (1990)
- Intact type 1 immunity and immune-associated coagulative responses in mice lacking IFN gamma-inducible fibrinogen-like protein 2. Hancock, W.W., Szaba, F.M., Berggren, K.N., Parent, M.A., Mullarky, I.K., Pearl, J., Cooper, A.M., Ely, K.H., Woodland, D.L., Kim, I.J., Blackman, M.A., Johnson, L.L., Smiley, S.T. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Fgl2 prothrombinase expression in mouse trophoblast and decidua triggers abortion but may be countered by OX-2. Clark, D.A., Ding, J.W., Yu, G., Levy, G.A., Gorczynski, R.M. Mol. Hum. Reprod. (2001)
- Kinetic analysis of a unique direct prothrombinase, fgl2, and identification of a serine residue critical for the prothrombinase activity. Chan, C.W., Chan, M.W., Liu, M., Fung, L., Cole, E.H., Leibowitz, J.L., Marsden, P.A., Clark, D.A., Levy, G.A. J. Immunol. (2002)
- Ribavirin inhibits viral-induced macrophage production of TNF, IL-1, the procoagulant fgl2 prothrombinase and preserves Th1 cytokine production but inhibits Th2 cytokine response. Ning, Q., Brown, D., Parodo, J., Cattral, M., Gorczynski, R., Cole, E., Fung, L., Ding, J.W., Liu, M.F., Rotstein, O., Phillips, M.J., Levy, G. J. Immunol. (1998)
- Loss of resistance to murine hepatitis virus strain 3 infection after treatment with corticosteroids is associated with induction of macrophage procoagulant activity. Fingerote, R.J., Abecassis, M., Phillips, M.J., Rao, Y.S., Cole, E.H., Leibowitz, J., Levy, G.A. J. Virol. (1996)
- Induction of macrophage procoagulant activity by murine hepatitis virus strain 3: role of tyrosine phosphorylation. Dackiw, A.P., Zakrzewski, K., Nathens, A.B., Cheung, P.Y., Fingerote, R., Levy, G.A., Rotstein, O.D. J. Virol. (1995)
- ABC1 promotes engulfment of apoptotic cells and transbilayer redistribution of phosphatidylserine. Hamon, Y., Broccardo, C., Chambenoit, O., Luciani, M.F., Toti, F., Chaslin, S., Freyssinet, J.M., Devaux, P.F., McNeish, J., Marguet, D., Chimini, G. Nat. Cell Biol. (2000)
- Basic residues of human group IIA phospholipase A2 are important for binding to factor Xa and prothrombinase inhibition comparison with other mammalian secreted phospholipases A2. Mounier, C.M., Luchetta, P., Lecut, C., Koduri, R.S., Faure, G., Lambeau, G., Valentin, E., Singer, A., Ghomashchi, F., Béguin, S., Gelb, M.H., Bon, C. Eur. J. Biochem. (2000)
- Assembly and regulation of prothrombinase complex on B16F10 melanoma cells. Kirszberg, C., Rumjanek, V.M., Monteiro, R.Q. Thromb. Res. (2005)
- Cellular and metabolic requirements for induction of macrophage procoagulant activity by murine hepatitis virus strain 3 in vitro. Chung, S., Sinclair, S., Leibowitz, J., Skamene, E., Fung, L.S., Levy, G. J. Immunol. (1991)
- Why did your mother reject you? Immunogenetic determinants of the response to environmental selective pressure expressed at the uterine level. Clark, D.A., Arck, P.C., Chaouat, G. Am. J. Reprod. Immunol. (1999)
- The cytotoxic T lymphocyte gene FIBLP with homology to fibrinogen beta and gamma subunits is also induced in mouse macrophages by IFN-gamma. Lafuse, W.P., Castle, L., Brown, D., Zwilling, B.S. Cell. Immunol. (1995)
- Murine hepatitis virus strain 3 induces the macrophage prothrombinase fgl-2 through p38 mitogen-activated protein kinase activation. McGilvray, I.D., Lu, Z., Wei, A.C., Dackiw, A.P., Marshall, J.C., Kapus, A., Levy, G., Rotstein, O.D. J. Biol. Chem. (1998)
- Factor VIIa-mediated tenase function on activated platelets under flow. Goel, M.S., Diamond, S.L. J. Thromb. Haemost. (2004)
- The fgl2 prothrombinase/fibroleukin gene is required for lipopolysaccharide-triggered abortions and for normal mouse reproduction. Clark, D.A., Foerster, K., Fung, L., He, W., Lee, L., Mendicino, M., Markert, U.R., Gorczynski, R.M., Marsden, P.A., Levy, G.A. Mol. Hum. Reprod. (2004)
- Novel mfgl2 antisense plasmid inhibits murine fgl2 expression and ameliorates murine hepatitis virus type 3-induced fulminant hepatitis in BALB/cJ mice. Zhu, C., Sun, Y., Luo, X., Yan, W., Xi, D., Ning, Q. Hum. Gene Ther. (2006)
- Treatment of resistant A/J mice with methylprednisolone (MP) results in loss of resistance to murine hepatitis strain 3 (MHV-3) and induction of macrophage procoagulant activity (PCA). Fingerote, R.J., Leibowitz, J.L., Rao, Y.S., Levy, G.A. Adv. Exp. Med. Biol. (1995)