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Gene Review

Mrgpra3  -  MAS-related GPR, member A3

Mus musculus

Synonyms: G protein-coupled receptor, Mas-related G-protein coupled receptor member A3, MrgA3, Mrga3
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Disease relevance of Mrgpra3


Psychiatry related information on Mrgpra3

  • Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: an association with early beta-amyloid accumulation [5].

High impact information on Mrgpra3

  • The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes [6].
  • Regulation of these ion channels via G protein-coupled receptor signaling underlies the control of heart rate and the actions of neurotransmitters in the central nervous system [7].
  • A G-protein-coupled receptor for nicotinic acid has been proposed in adipocytes [8].
  • Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons [9].
  • We report a role for PAR1, a protease-activated G protein-coupled receptor for thrombin, in embryonic development [10].

Chemical compound and disease context of Mrgpra3

  • The action of Noci appears to be mediated by the Noci receptor, a pertussis toxin-sensitive G protein-coupled receptor that stimulates inositol trisphosphate receptor and Ca2+ influx [11].
  • Serotonin 5-HT(4(a)) receptor, a G-protein-coupled receptor (GPCR), was produced as a functional isolated protein using Escherichia coli as an expression system [12].
  • Signaling of the C3a anaphylatoxin through its G protein-coupled receptor, C3aR, is relevant in a variety of inflammatory diseases, but its role in lupus nephritis is undefined [13].
  • Lysophosphatidic acid (LPA) is a lipid-derived G-protein-coupled receptor (GPCR) agonist that is involved in a variety of physiological and pathological processes, including cell survival, proliferation and differentiation, cytoskeletal rearrangement, cell-cell interactions, tumorigenesis and cell invasion [14].
  • Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development [15].

Biological context of Mrgpra3

  • Here we show that GIT2 was necessary for directional chemotaxis and for the suppression of superoxide production in G protein-coupled receptor-stimulated neutrophils [16].
  • Desensitization of G protein-coupled receptors is mediated via phosphorylation by members of the family of G protein-coupled receptor kinases (GRK1-GRK7) [17].
  • The role of G2A in LPC-mediated cell migration may be relevant to the autoimmune syndrome associated with genetic inactivation of this G protein-coupled receptor in mice [18].
  • A DNA sequence encoding a G-protein-coupled receptor was isolated from a mouse genomic library [19].
  • We established lentiviral-based RNA interference in J774A.1 mouse macrophages to characterize the role of Gbeta in G protein-coupled receptor signaling [20].

Anatomical context of Mrgpra3

  • GPR105 is a G-protein-coupled receptor identifying a quiescent, primitive population of hematopoietic cells restricted to bone marrow [21].
  • Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1 [22].
  • These findings implicate a G protein-coupled receptor in lymphocyte migration into splenic white pulp cords [23].
  • The N-formylpeptide receptor (FPR) is a G protein-coupled receptor that mediates mammalian phagocyte chemotactic responses to bacterial N-formylpeptides [24].
  • It has been reported recently that T cells lacking beta-arrestin-2, a G protein-coupled receptor regulatory protein, demonstrate impaired migration in vitro [25].

Associations of Mrgpra3 with chemical compounds

  • We found that the amplitude of the glycine-activated Cl- current was enhanced after application of purified Gbetagamma or after activation of a G protein-coupled receptor [26].
  • Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET [27].
  • C3a binds to a seven-transmembrane G protein-coupled receptor, C3aR [28].
  • We describe a novel signaling mechanism mediated by the G-protein-coupled receptor (GPCR) angiotensin II (Ang II) type 2 receptor (AT(2)) [29].
  • We demonstrate the feasibility of the approach by binding NTA-chromophore conjugates to a representative ligand-gated ion channel and G protein-coupled receptor, each containing a polyhistidine sequence [30].

Enzymatic interactions of Mrgpra3


Other interactions of Mrgpra3


Analytical, diagnostic and therapeutic context of Mrgpra3

  • Physiological roles of G-protein-coupled receptor kinases revealed by gene-targeting technology [37].
  • The analgesia produced by inhibitory G protein-coupled receptor agonists involves coordinated postsynaptic inhibition via G protein-coupled inwardly rectifying potassium channels (GIRKs) and presynaptic inhibition of neurotransmitter release through regulation of voltage-gated Ca(2+) channels [38].
  • RESULTS: Fluorescence video microscopy of yeast cells expressing a GFP-tagged G protein-coupled receptor (Ste2-GFP) as an endocytic marker revealed that endosomes and the lysosome-like vacuole are highly motile [39].
  • A novel G protein-coupled receptor was cloned by PCR and homology screening [40].
  • Molecular cloning of a new member of the putative G protein-coupled receptor gene from barnacle Balanus amphitrite [41].


  1. G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Bais, C., Santomasso, B., Coso, O., Arvanitakis, L., Raaka, E.G., Gutkind, J.S., Asch, A.S., Cesarman, E., Gershengorn, M.C., Mesri, E.A., Gerhengorn, M.C. Nature (1998) [Pubmed]
  2. Chemokines activate Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. Gershengorn, M.C., Geras-Raaka, E., Varma, A., Clark-Lewis, I. J. Clin. Invest. (1998) [Pubmed]
  3. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., Froguel, P. J. Clin. Invest. (2000) [Pubmed]
  4. Murine cytomegalovirus M78 protein, a G protein-coupled receptor homologue, is a constituent of the virion and facilitates accumulation of immediate-early viral mRNA. Oliveira, S.A., Shenk, T.E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  5. Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: an association with early beta-amyloid accumulation. Suo, Z., Wu, M., Citron, B.A., Wong, G.T., Festoff, B.W. J. Neurosci. (2004) [Pubmed]
  6. Dopamine receptors: from structure to function. Missale, C., Nash, S.R., Robinson, S.W., Jaber, M., Caron, M.G. Physiol. Rev. (1998) [Pubmed]
  7. Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution. Nishida, M., MacKinnon, R. Cell (2002) [Pubmed]
  8. PUMA-G and HM74 are receptors for nicotinic acid and mediate its anti-lipolytic effect. Tunaru, S., Kero, J., Schaub, A., Wufka, C., Blaukat, A., Pfeffer, K., Offermanns, S. Nat. Med. (2003) [Pubmed]
  9. The temporal requirement for endothelin receptor-B signalling during neural crest development. Shin, M.K., Levorse, J.M., Ingram, R.S., Tilghman, S.M. Nature (1999) [Pubmed]
  10. A role for thrombin receptor signaling in endothelial cells during embryonic development. Griffin, C.T., Srinivasan, Y., Zheng, Y.W., Huang, W., Coughlin, S.R. Science (2001) [Pubmed]
  11. Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice. Inoue, M., Kobayashi, M., Kozaki, S., Zimmer, A., Ueda, H. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  12. Molecular characterization of a purified 5-HT4 receptor: a structural basis for drug efficacy. Banères, J.L., Mesnier, D., Martin, A., Joubert, L., Dumuis, A., Bockaert, J. J. Biol. Chem. (2005) [Pubmed]
  13. Signaling through up-regulated C3a receptor is key to the development of experimental lupus nephritis. Bao, L., Osawe, I., Haas, M., Quigg, R.J. J. Immunol. (2005) [Pubmed]
  14. Roles of LPA3 and COX-2 in implantation. Shah, B.H., Catt, K.J. Trends Endocrinol. Metab. (2005) [Pubmed]
  15. Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development. Marín, Y.E., Chen, S. J. Mol. Med. (2004) [Pubmed]
  16. Neutrophil direction sensing and superoxide production linked by the GTPase-activating protein GIT2. Mazaki, Y., Hashimoto, S., Tsujimura, T., Morishige, M., Hashimoto, A., Aritake, K., Yamada, A., Nam, J.M., Kiyonari, H., Nakao, K., Sabe, H. Nat. Immunol. (2006) [Pubmed]
  17. Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Gainetdinov, R.R., Bohn, L.M., Sotnikova, T.D., Cyr, M., Laakso, A., Macrae, A.D., Torres, G.E., Kim, K.M., Lefkowitz, R.J., Caron, M.G., Premont, R.T. Neuron (2003) [Pubmed]
  18. T cell chemotaxis to lysophosphatidylcholine through the G2A receptor. Radu, C.G., Yang, L.V., Riedinger, M., Au, M., Witte, O.N. Proc. Natl. Acad. Sci. U.S.A. (2004) [Pubmed]
  19. Molecular cloning of a potential proteinase activated receptor. Nystedt, S., Emilsson, K., Wahlestedt, C., Sundelin, J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  20. Silencing the expression of multiple Gbeta-subunits eliminates signaling mediated by all four families of G proteins. Hwang, J.I., Choi, S., Fraser, I.D., Chang, M.S., Simon, M.I. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  21. P2Y-like receptor, GPR105 (P2Y14), identifies and mediates chemotaxis of bone-marrow hematopoietic stem cells. Lee, B.C., Cheng, T., Adams, G.B., Attar, E.C., Miura, N., Lee, S.B., Saito, Y., Olszak, I., Dombkowski, D., Olson, D.P., Hancock, J., Choi, P.S., Haber, D.A., Luster, A.D., Scadden, D.T. Genes Dev. (2003) [Pubmed]
  22. Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment. Tager, A.M., Bromley, S.K., Medoff, B.D., Islam, S.A., Bercury, S.D., Friedrich, E.B., Carafone, A.D., Gerszten, R.E., Luster, A.D. Nat. Immunol. (2003) [Pubmed]
  23. Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords. Cyster, J.G., Goodnow, C.C. J. Exp. Med. (1995) [Pubmed]
  24. N-formylpeptides induce two distinct concentration optima for mouse neutrophil chemotaxis by differential interaction with two N-formylpeptide receptor (FPR) subtypes. Molecular characterization of FPR2, a second mouse neutrophil FPR. Hartt, J.K., Barish, G., Murphy, P.M., Gao, J.L. J. Exp. Med. (1999) [Pubmed]
  25. Beta-arrestin-2 regulates the development of allergic asthma. Walker, J.K., Fong, A.M., Lawson, B.L., Savov, J.D., Patel, D.D., Schwartz, D.A., Lefkowitz, R.J. J. Clin. Invest. (2003) [Pubmed]
  26. Modulation of glycine-activated ion channel function by G-protein betagamma subunits. Yevenes, G.E., Peoples, R.W., Tapia, J.C., Parodi, J., Soto, X., Olate, J., Aguayo, L.G. Nat. Neurosci. (2003) [Pubmed]
  27. Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET. Barlow, A., de Graaff, E., Pachnis, V. Neuron (2003) [Pubmed]
  28. The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen. Kawamoto, S., Yalcindag, A., Laouini, D., Brodeur, S., Bryce, P., Lu, B., Humbles, A.A., Oettgen, H., Gerard, C., Geha, R.S. J. Clin. Invest. (2004) [Pubmed]
  29. A novel angiotensin II type 2 receptor signaling pathway: possible role in cardiac hypertrophy. Senbonmatsu, T., Saito, T., Landon, E.J., Watanabe, O., Price, E., Roberts, R.L., Imboden, H., Fitzgerald, T.G., Gaffney, F.A., Inagami, T. EMBO J. (2003) [Pubmed]
  30. Reversible site-selective labeling of membrane proteins in live cells. Guignet, E.G., Hovius, R., Vogel, H. Nat. Biotechnol. (2004) [Pubmed]
  31. Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. Eckhart, A.D., Duncan, S.J., Penn, R.B., Benovic, J.L., Lefkowitz, R.J., Koch, W.J. Circ. Res. (2000) [Pubmed]
  32. Mas oncogene signaling and transformation require the small GTP-binding protein Rac. Zohn, I.E., Symons, M., Chrzanowska-Wodnicka, M., Westwick, J.K., Der, C.J. Mol. Cell. Biol. (1998) [Pubmed]
  33. Identification of a putative G protein-coupled receptor induced during activation-induced apoptosis of T cells. Choi, J.W., Lee, S.Y., Choi, Y. Cell. Immunol. (1996) [Pubmed]
  34. Requirement of cortical actin organization for bombesin, endothelin, and EGF receptor internalization. Lunn, J.A., Wong, H., Rozengurt, E., Walsh, J.H. Am. J. Physiol., Cell Physiol. (2000) [Pubmed]
  35. Molecular mechanisms of G protein-coupled receptor signaling: role of G protein-coupled receptor kinases and arrestins in receptor desensitization and resensitization. Zhang, J., Ferguson, S.S., Barak, L.S., Aber, M.J., Giros, B., Lefkowitz, R.J., Caron, M.G. Recept. Channels (1997) [Pubmed]
  36. Molecular mechanisms underlying differential odor responses of a mouse olfactory receptor. Floriano, W.B., Vaidehi, N., Goddard, W.A., Singer, M.S., Shepherd, G.M. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  37. Physiological roles of G-protein-coupled receptor kinases revealed by gene-targeting technology. Wess, J. Trends Pharmacol. Sci. (2000) [Pubmed]
  38. Contribution of GIRK2-mediated postsynaptic signaling to opiate and alpha 2-adrenergic analgesia and analgesic sex differences. Mitrovic, I., Margeta-Mitrovic, M., Bader, S., Stoffel, M., Jan, L.Y., Basbaum, A.I. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  39. A WASp homolog powers actin polymerization-dependent motility of endosomes in vivo. Chang, F.S., Stefan, C.J., Blumer, K.J. Curr. Biol. (2003) [Pubmed]
  40. Molecular cloning and tissue distribution of a putative member of the rat opioid receptor gene family that is not a mu, delta or kappa opioid receptor type. Bunzow, J.R., Saez, C., Mortrud, M., Bouvier, C., Williams, J.T., Low, M., Grandy, D.K. FEBS Lett. (1994) [Pubmed]
  41. Molecular cloning of a new member of the putative G protein-coupled receptor gene from barnacle Balanus amphitrite. Isoai, A., Kawahara, H., Okazaki, Y., Shizuri, Y. Gene (1996) [Pubmed]
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