Disease relevance of Mrgpra3

• G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator [1].
• The G-protein-coupled receptor encoded by an open reading frame (ORF 74) of KSHV is expressed in Kaposi's sarcoma lesions and in PEL and stimulates signalling pathways linked to cell proliferation in a constitutive (agonist-independent) way [1].
• Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus 8, a virus that appears to be involved in the pathogenesis of Kaposi's sarcoma and primary effusion lymphomas, encodes a G protein-coupled receptor (KSHV-GPCR) that exhibits constitutive signaling [2].
• Inactivation of the gene encoding this G protein-coupled receptor causes obesity in mice [3].
• The M78 protein of murine cytomegalovirus exhibits sequence features of a G protein-coupled receptor [4].

Psychiatry related information on Mrgpra3

• Abnormality of G-protein-coupled receptor kinases at prodromal and early stages of Alzheimer's disease: an association with early beta-amyloid accumulation [5].

High impact information on Mrgpra3

• The diverse physiological actions of dopamine are mediated by at least five distinct G protein-coupled receptor subtypes [6].
• Regulation of these ion channels via G protein-coupled receptor signaling underlies the control of heart rate and the actions of neurotransmitters in the central nervous system [7].
• A G-protein-coupled receptor for nicotinic acid has been proposed in adipocytes [8].
• Endothelin receptor B (EDNRB) is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons [9].
• We report a role for PAR1, a protease-activated G protein-coupled receptor for thrombin, in embryonic development [10].

Chemical compound and disease context of Mrgpra3

• The action of Noci appears to be mediated by the Noci receptor, a pertussis toxin-sensitive G protein-coupled receptor that stimulates inositol trisphosphate receptor and Ca2+ influx [11].
• Serotonin 5-HT(4(a)) receptor, a G-protein-coupled receptor (GPCR), was produced as a functional isolated protein using Escherichia coli as an expression system [12].
• Signaling of the C3a anaphylatoxin through its G protein-coupled receptor, C3aR, is relevant in a variety of inflammatory diseases, but its role in lupus nephritis is undefined [13].
• Lysophosphatidic acid (LPA) is a lipid-derived G-protein-coupled receptor (GPCR) agonist that is involved in a variety of physiological and pathological processes, including cell survival, proliferation and differentiation, cytoskeletal rearrangement, cell-cell interactions, tumorigenesis and cell invasion [14].
• Involvement of metabotropic glutamate receptor 1, a G protein coupled receptor, in melanoma development [15].

Biological context of Mrgpra3

• Here we show that GIT2 was necessary for directional chemotaxis and for the suppression of superoxide production in G protein-coupled receptor-stimulated neutrophils [16].
• Desensitization of G protein-coupled receptors is mediated via phosphorylation by members of the family of G protein-coupled receptor kinases (GRK1-GRK7) [17].
• The role of G2A in LPC-mediated cell migration may be relevant to the autoimmune syndrome associated with genetic inactivation of this G protein-coupled receptor in mice [18].
• A DNA sequence encoding a G-protein-coupled receptor was isolated from a mouse genomic library [19].
• We established lentiviral-based RNA interference in J774A.1 mouse macrophages to characterize the role of Gbeta in G protein-coupled receptor signaling [20].

Anatomical context of Mrgpra3

• GPR105 is a G-protein-coupled receptor identifying a quiescent, primitive population of hematopoietic cells restricted to bone marrow [21].
• Leukotriene B4 (LTB4) was originally described as a potent lipid myeloid cell chemoattractant, rapidly generated from innate immune cells, that activates leukocytes through the G protein-coupled receptor BLT1 [22].
• These findings implicate a G protein-coupled receptor in lymphocyte migration into splenic white pulp cords [23].
• The N-formylpeptide receptor (FPR) is a G protein-coupled receptor that mediates mammalian phagocyte chemotactic responses to bacterial N-formylpeptides [24].
• It has been reported recently that T cells lacking beta-arrestin-2, a G protein-coupled receptor regulatory protein, demonstrate impaired migration in vitro [25].

Associations of Mrgpra3 with chemical compounds

• We found that the amplitude of the glycine-activated Cl- current was enhanced after application of purified Gbetagamma or after activation of a G protein-coupled receptor [26].
• Enteric nervous system progenitors are coordinately controlled by the G protein-coupled receptor EDNRB and the receptor tyrosine kinase RET [27].
• C3a binds to a seven-transmembrane G protein-coupled receptor, C3aR [28].
• We describe a novel signaling mechanism mediated by the G-protein-coupled receptor (GPCR) angiotensin II (Ang II) type 2 receptor (AT(2)) [29].
• We demonstrate the feasibility of the approach by binding NTA-chromophore conjugates to a representative ligand-gated ion channel and G protein-coupled receptor, each containing a polyhistidine sequence [30].

Enzymatic interactions of Mrgpra3

• G protein-coupled receptor kinases (GRKs) phosphorylate activated G protein-coupled receptors, including alpha(1B)-adrenergic receptors (ARs), resulting in desensitization [31].

Other interactions of Mrgpra3

• The Mas oncogene encodes a novel G-protein-coupled receptor that was identified originally as a transforming protein when overexpressed in NIH 3T3 cells [32].
• Using the technique of differential mRNA display, we have identified a novel gene, TDAG8, which encodes a putative G protein-coupled receptor [33].
• The potency of latrunculin A for inhibiting G protein-coupled receptor endocytosis was comparable to that for reducing internalization of the epidermal growth factor tyrosine kinase receptor [34].
• Studies on the specificity of beta-arrestin functions reveal a multiplicity of G protein-coupled receptor endocytic pathways and suggest that beta-arrestins might serve as adaptors specifically targeting receptors for dynamin-dependent clathrin-mediated endocytosis [35].
• The results provide a mechanistic model for olfactory transduction at the molecular level and show how the basic G protein-coupled receptor template is adapted for encoding the enormous odor space [36].

Analytical, diagnostic and therapeutic context of Mrgpra3

• Physiological roles of G-protein-coupled receptor kinases revealed by gene-targeting technology [37].
• The analgesia produced by inhibitory G protein-coupled receptor agonists involves coordinated postsynaptic inhibition via G protein-coupled inwardly rectifying potassium channels (GIRKs) and presynaptic inhibition of neurotransmitter release through regulation of voltage-gated Ca(2+) channels [38].
• RESULTS: Fluorescence video microscopy of yeast cells expressing a GFP-tagged G protein-coupled receptor (Ste2-GFP) as an endocytic marker revealed that endosomes and the lysosome-like vacuole are highly motile [39].
• A novel G protein-coupled receptor was cloned by PCR and homology screening [40].
• Molecular cloning of a new member of the putative G protein-coupled receptor gene from barnacle Balanus amphitrite [41].

References