Disease relevance of delta-Hydroxylysine

• Metabolism of 5-hydroxylysine in Pseudomonas fluorescens [1].
• Effects of 5-hydroxylysine on acetylene reduction and NH4+-assimilation in the cyanobacterium Anabaena cylindrica [2].
• 5-Hydroxy-L-lysine excretion in cystinuria [3].
• Urinary excretion of 5-hydroxylysine (Hyl) and its two glycosides, a monoglycoside (Gal-Hyl) and a diglycoside (Glc-Gal-Hyl), and the ratio of the diglycoside to monoglycoside have been studied in 30 patients with Turner's syndrome and in 38 healthy controls [4].

High impact information on delta-Hydroxylysine

• In contrast, the glutamine synthetase inhibitor delta-hydroxylysine demonstrated activity only against TE-671 [5].
• Determination of methylated basic, 5-hydroxylysine, elastin crosslinks, other amino acids, and the amino sugars in proteins and tissues [6].
• Collagen was also detected by evaluating two characteristic amino acids, 4-hydroxyproline (4-hypro) with a colorimetric method and 5-hydroxylysine (5-hylys) by gas chromatography [7].
• Collagen and collagen-like proteins in the extracellular matrix protein fractions were calculated from the amounts of 5-hydroxylysine found in their 96-h acid hydrolysates and elastin content from the amounts of desmosine present [8].
• Guanosine triphosphate: 5-hydroxylysine phosphotransferase in rat kidney cortex [9].

Biological context of delta-Hydroxylysine

• This method should be especially valuable for determining collagen and elastin in tissue hydrolysates from the amounts of 5-hydroxylysine, and desmosine or isodesmosine present, respectively, and for studying protein hydroxylation, glycosylation, cross-linking formation, and the turnover rates of collagen and elastin in normal and diseased tissues [10].

Anatomical context of delta-Hydroxylysine

• An enzyme which catalyzes the transfer of the gamma-phosphate from GTP onto 5-hydroxylysine was partially purified from rat kidney cortex by means of acid precipitation and DEAE-Sephadex A-50 column chromatography [9].

References