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Chemical Compound Review

CHEMBL145167     2,6-diamino-5-hydroxy-hexanoic acid

Synonyms: CHEBI:60175, AC1L1AKK, CTK8I0286, SBB071710, AR-1G8540, ...
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Disease relevance of delta-Hydroxylysine


High impact information on delta-Hydroxylysine


Biological context of delta-Hydroxylysine

  • This method should be especially valuable for determining collagen and elastin in tissue hydrolysates from the amounts of 5-hydroxylysine, and desmosine or isodesmosine present, respectively, and for studying protein hydroxylation, glycosylation, cross-linking formation, and the turnover rates of collagen and elastin in normal and diseased tissues [10].

Anatomical context of delta-Hydroxylysine

  • An enzyme which catalyzes the transfer of the gamma-phosphate from GTP onto 5-hydroxylysine was partially purified from rat kidney cortex by means of acid precipitation and DEAE-Sephadex A-50 column chromatography [9].


  1. Metabolism of 5-hydroxylysine in Pseudomonas fluorescens. Friede, J.D., Henderson, L.M. J. Bacteriol. (1976) [Pubmed]
  2. Effects of 5-hydroxylysine on acetylene reduction and NH4+-assimilation in the cyanobacterium Anabaena cylindrica. Ladha, J.K., Rowell, P., Stewart, W.D. Biochem. Biophys. Res. Commun. (1978) [Pubmed]
  3. 5-Hydroxy-L-lysine excretion in cystinuria. Roesel, R.A., Blankenship, P.R., Ganapathy, V., Leibach, F.H. J. Inherit. Metab. Dis. (1985) [Pubmed]
  4. Urinary hydroxylysine and hydroxylysyl glycosides excretion in patients with Turner's syndrome. Larizza, D., Lorini, R., Franchini, M., Tenni, R., Salvatoni, A., Severi, F. Horm. Metab. Res. (1985) [Pubmed]
  5. Influence of glutamine on the growth of human glioma and medulloblastoma in culture. Dranoff, G., Elion, G.B., Friedman, H.S., Campbell, G.L., Bigner, D.D. Cancer Res. (1985) [Pubmed]
  6. Determination of methylated basic, 5-hydroxylysine, elastin crosslinks, other amino acids, and the amino sugars in proteins and tissues. Zarkadas, C.G., Rochemont, J.A., Zarkadas, G.C., Karatzas, C.N., Khalili, A.D. Anal. Biochem. (1987) [Pubmed]
  7. Alteration of elastin, collagen and their cross-links in abdominal aortic aneurysms. Carmo, M., Colombo, L., Bruno, A., Corsi, F.R., Roncoroni, L., Cuttin, M.S., Radice, F., Mussini, E., Settembrini, P.G. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery. (2002) [Pubmed]
  8. Comparison of the amino acid composition of the intracellular and extracellular matrix protein fractions isolated from avian skeletal muscles. Karatzas, C.N., Zarkadas, C.G. Poult. Sci. (1989) [Pubmed]
  9. Guanosine triphosphate: 5-hydroxylysine phosphotransferase in rat kidney cortex. Chang, A.Y. Enzyme (1977) [Pubmed]
  10. Rapid method for determining desmosine, isodesmosine, 5-hydroxylysine, tryptophan, lysinoalanine and the amino sugars in proteins and tissues. Zarkadas, C.G., Zarkadas, G.C., Karatzas, C.N., Khalili, A.D., Nguyen, Q. J. Chromatogr. (1986) [Pubmed]
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