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Chemical Compound Review

pyridoxine-P     [5-hydroxy-4-(hydroxymethyl)- 6-methyl...

Synonyms: pyridoxine-5P, SureCN43880, CHEBI:28803, HMDB01319, NSC-83119, ...
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Disease relevance of pyridoxine-P


High impact information on pyridoxine-P

  • Torpedo californica acetylcholine receptor (AcChR) vesicles were loaded with [3H]pyridoxine 5-phosphate ([3H]PNP) and pyridoxine-5-phosphate oxidase, followed by intravesicular enzymatic oxidation of [3H]PNP at 37 degrees C in the presence of externally added cytochrome c as a scavenger of possible leaking PLP product [4].
  • To identify the roles of pyridoxine-5'-phosphate (PNP) oxidase in epileptogenesis and the recovery mechanisms in spontaneous seizure, a chronological and comparative analysis of PNP oxidase expression was conducted [5].
  • Although the specific reaction in phenazine biosynthesis catalyzed by PhzG is unknown, the structural data indicates that PhzG is closely related to pyridoxine-5'-phosphate oxidase, the Escherichia coli pdxH gene product, which catalyzes the final step in pyridoxal-5'-phosphate (PLP) biosynthesis [6].
  • METHODS: Predialysis serum pyridoxal-5'-phosphate (P5P) level was determined in 36 chronic HD patients who were undergoing high-flux HD and receiving human recombinant erythropoietin [7].
  • This contrast agent is derived from pyridoxyl-5-phosphate which is biomimetically designed to be secreted by the hepatocyte [8].

Anatomical context of pyridoxine-P


Analytical, diagnostic and therapeutic context of pyridoxine-P


  1. Transport and metabolism of vitamin B6 in lactic acid bacteria. Mulligan, J.H., Snell, E.E. J. Biol. Chem. (1977) [Pubmed]
  2. Active site structure and stereospecificity of Escherichia coli pyridoxine-5'-phosphate oxidase. di Salvo, M.L., Ko, T.P., Musayev, F.N., Raboni, S., Schirch, V., Safo, M.K. J. Mol. Biol. (2002) [Pubmed]
  3. Purinergic component of mechanosensory transduction is increased in a rat model of colitis. Wynn, G., Ma, B., Ruan, H.Z., Burnstock, G. Am. J. Physiol. Gastrointest. Liver Physiol. (2004) [Pubmed]
  4. Pyridoxal phosphate as a probe of the cytoplasmic domains of transmembrane proteins: application to the nicotinic acetylcholine receptor. Perez-Ramirez, B., Martinez-Carrion, M. Biochemistry (1989) [Pubmed]
  5. Chronological changes in pyridoxine-5'-phosphate oxidase immunoreactivity in the seizure-sensitive gerbil hippocampus. Kang, T.C., Park, S.K., Hwang, I.K., An, S.J., Bahn, J.H., Kim, A.Y., Choi, S.Y., Kwon, O.S., Baek, N.I., Lee, H.Y., Won, M.H. J. Neurosci. Res. (2002) [Pubmed]
  6. Structure of the phenazine biosynthesis enzyme PhzG. Parsons, J.F., Calabrese, K., Eisenstein, E., Ladner, J.E. Acta Crystallogr. D Biol. Crystallogr. (2004) [Pubmed]
  7. Vitamin B6 supplementation can improve peripheral polyneuropathy in patients with chronic renal failure on high-flux haemodialysis and human recombinant erythropoietin. Okada, H., Moriwaki, K., Kanno, Y., Sugahara, S., Nakamoto, H., Yoshizawa, M., Suzuki, H. Nephrol. Dial. Transplant. (2000) [Pubmed]
  8. Detection of hepatic malignancies using Mn-DPDP (manganese dipyridoxal diphosphate) hepatobiliary MRI contrast agent. Young, S.W., Bradley, B., Muller, H.H., Rubin, D.L. Magnetic resonance imaging. (1990) [Pubmed]
  9. Immunohistochemical studies of brain pyridoxine-5'-phosphate oxidase. Bahn, J.H., Kwon, O.S., Joo, H.M., Ho Jang, S., Park, J., Hwang, I.K., Kang, T.C., Won, M.H., Yil Kwon, H., Kwok, F., Kim, H.B., Cho, S.W., Choi, S.Y. Brain Res. (2002) [Pubmed]
  10. Brain pyridoxine-5-phosphate oxidase. A dimeric enzyme containing one FMN site. Churchich, J.E. Eur. J. Biochem. (1984) [Pubmed]
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