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Chemical Compound Review

pyridoxal-P     (5-hydroxy-4-methanoyl-6- methyl-pyridin-3...

Synonyms: Biosechs, Hairoxal, Hiadelon, Himitan, Pidopidon, ...
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Disease relevance of pyridoxal phosphate


High impact information on pyridoxal phosphate


Chemical compound and disease context of pyridoxal phosphate


Biological context of pyridoxal phosphate


Anatomical context of pyridoxal phosphate

  • Human erythrocytes rapidly convert vitamin B6 to pyridoxal-P and contain soluble phosphatase activity which dephosphorylates pyridoxal-P at a pH optimum of 6-6 [19].
  • These data indicate that pyridoxal-P can rapidly enter the intermembrane space of isolated mitochondria, but its penetration into the matrix occurs at a slower and more sustained rate (i.e. 9-16 pmol/h/mg of protein) [18].
  • A nondialyzable inhibitor was apparently formed when intact microsomes were reacted with pyridoxal-P and NaBH4; this inhibition was also reversed by procedures which changed the kinetic properties of glucose-6-phosphatase [20].
  • Pyridoxal-P is not hydrolyzed by the acid phosphatase of intact lysosomes [15].
  • Additionally, as reflected by the lower specific radioactivity of [14C]pyridoxal-P in mitochondria than that in cytosol, the extent of mixing of newly synthesized and endogenous pools of pyridoxal-P in these subcellular compartments is heterogeneous [21].

Associations of pyridoxal phosphate with other chemical compounds


Gene context of pyridoxal phosphate


Analytical, diagnostic and therapeutic context of pyridoxal phosphate


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  2. Structure-function relationships of cyanobacterial ADP-glucose pyrophosphorylase. Site-directed mutagenesis and chemical modification of the activator-binding sites of ADP-glucose pyrophosphorylase from Anabaena PCC 7120. Charng, Y.Y., Iglesias, A.A., Preiss, J. J. Biol. Chem. (1994) [Pubmed]
  3. Elevated plasma 4-pyridoxic acid in renal insufficiency. Coburn, S.P., Reynolds, R.D., Mahuren, J.D., Schaltenbrand, W.E., Wang, Y., Ericson, K.L., Whyte, M.P., Zubovic, Y.M., Ziegler, P.J., Costill, D.L., Fink, W.J., Pearson, D.R., Pauly, T.A., Thampy, K.G., Wortsman, J. Am. J. Clin. Nutr. (2002) [Pubmed]
  4. Pyridine analogs inhibit the glucosyltransferase of Streptococcus mutans. Thaniyavarn, S., Taylor, K.G., Singh, S., Doyle, R.J. Infect. Immun. (1982) [Pubmed]
  5. The Arabidopsis salt overly sensitive 4 mutants uncover a critical role for vitamin B6 in plant salt tolerance. Shi, H., Xiong, L., Stevenson, B., Lu, T., Zhu, J.K. Plant Cell (2002) [Pubmed]
  6. Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission. Wolosker, H., Blackshaw, S., Snyder, S.H. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  7. Preparation and characterization of a modified form of beta2 subunit of Escherichia coli tryptophan synthetase suitable for investigating protein folding. Högberg-Raibaud, A., Goldberg, M.E. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  8. Effect of L-tryptophan excess and vitamin B6 deficiency on rat urinary bladder cancer promotion. Birt, D.F., Julius, A.D., Hasegawa, R., St John, M., Cohen, S.M. Cancer Res. (1987) [Pubmed]
  9. Biosynthesis of bacterial glycogen. Kinetic studies of a glucose-1-phosphate adenylyltransferase (EC from a glycogen-deficient mutant of Escherichia coli B. Preiss, J., Greenberg, E., Sabraw, A. J. Biol. Chem. (1975) [Pubmed]
  10. Biosynthesis of bacterial glycogen. Isolation and characterization of the pyridoxal-P allosteric activator site and the ADP-glucose-protected pyridoxal-P binding site of Escherichia coli B ADP-glucose synthase. Parsons, T.F., Preiss, J. J. Biol. Chem. (1978) [Pubmed]
  11. Mechanism of action of D-serine dehydratase. Identification of a transient intermediate. Schnackerz, K.D., Ehrlich, J.H., Giesemann, W., Reed, T.A. Biochemistry (1979) [Pubmed]
  12. Pyridoxal 5'-phosphate as a 31P reporter observing functional changes in the active site of Escherichia coli maltodextrin phosphorylase after site-directed mutagenesis. Schinzel, R., Palm, D., Schnackerz, K.D. Biochemistry (1992) [Pubmed]
  13. Magnetic resonance imaging of acute myocardial ischemia using a manganese chelate, Mn-DPDP. Pomeroy, O.H., Wendland, M., Wagner, S., Derugin, N., Holt, W.W., Rocklage, S.M., Quay, S., Higgins, C.B. Investigative radiology. (1989) [Pubmed]
  14. The dissociated tryptophanase subunit is inactive. Raibaud, O., Goldberg, M.E. J. Biol. Chem. (1976) [Pubmed]
  15. Characterization of the pyridoxal 5'-phosphate and pyridoxamine 5'-phosphate hydrolase activity in rat liver. Identity with alkaline phosphatase. Lumeng, L., Li, T.K. J. Biol. Chem. (1975) [Pubmed]
  16. Diaminopropionate ammonia-lyase from Salmonella typhimurium. Purification and characterization of the crystalline enzyme, and sequence determination of the pyridoxal 5'-phosphate binding peptide. Nagasawa, T., Tanizawa, K., Satoda, T., Yamada, H. J. Biol. Chem. (1988) [Pubmed]
  17. Carbon 13 NMR study of nonenzymatic reactions of pyridoxal 5'-phosphate with selected amino acids and of related reactions. Dalling, D.K., Grant, D.M., Horton, W.J., Sagers, R.D. J. Biol. Chem. (1976) [Pubmed]
  18. Transport of pyridoxine and pyridoxal 5'-phosphate in isolated rat liver mitochondria. Lui, A., Lumeng, L., Li, T.K. J. Biol. Chem. (1982) [Pubmed]
  19. Purification and characterization of vitamin B6-phosphate phosphatase from human erythrocytes. Fonda, M.L. J. Biol. Chem. (1992) [Pubmed]
  20. Relationship between microsomal membrane permeability and the inhibition of hepatic glucose-6-phosphatase by pyridoxal phosphate. Gold, G., Widnell, C.C. J. Biol. Chem. (1976) [Pubmed]
  21. Metabolism of vitamin B6 in rat liver mitochondria. Lui, A., Lumeng, L., Li, T.K. J. Biol. Chem. (1981) [Pubmed]
  22. Structure-function relations in platelet-thrombin reactions. Inhibition of platelet-thrombin interactions by lysine modification. White, G.C., Lundblad, R.L., Griffith, M.J. J. Biol. Chem. (1981) [Pubmed]
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  30. Isolation and expression of a cDNA clone encoding human kynureninase. Alberati-Giani, D., Buchli, R., Malherbe, P., Broger, C., Lang, G., Köhler, C., Lahm, H.W., Cesura, A.M. Eur. J. Biochem. (1996) [Pubmed]
  31. Catalytic site of rabbit glycogen synthase isozymes. Identification of an active site lysine close to the amino terminus of the subunit. Mahrenholz, A.M., Wang, Y.H., Roach, P.J. J. Biol. Chem. (1988) [Pubmed]
  32. Vitamin B6 deficiency in uremia. Stone, W.J., Warnock, L.G., Wagner, C. Am. J. Clin. Nutr. (1975) [Pubmed]
  33. Pyridoxal 5'-phosphate and analogs as probes of coenzyme-protein interaction in Baccillus alvei tryptophanase. Isom, H.C., DeMoss, R.D. Biochemistry (1975) [Pubmed]
  34. Hypothalamic cathepsin D: assay and isoenzyme composition. Akopyan, T.N., Barchudaryan, N.A., Karabashyan, L.V., Arutunyan, A.A., Lajtha, A., Galoyan, A.A. J. Neurosci. Res. (1979) [Pubmed]
  35. Plasma pyridoxal-5-phosphate level as risk index for coronary artery disease. Serfontein, W.J., Ubbink, J.B., De Villiers, L.S., Rapley, C.H., Becker, P.J. Atherosclerosis (1985) [Pubmed]
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