Disease relevance of Tryptophol

• This gene (ipdC) conferred the synthesis of indole-3-acetaldehyde and tryptophol upon Escherichia coli DH5 alpha in cultures supplemented with L-tryptophan [1].
• These results suggest that trypanosome-produced tryptophol may account for the immunodepression observed during trypanosomiasis [2].

High impact information on Tryptophol

• We prepared, purified, and characterized radiolabeled tryptophol for the purpose of defining its tissue distribution in animals [3].
• The pathways of short-term tryptophan metabolism in rats infected with Trypanosoma brucei gambiense were studied to determine whether this amino acid undergoes rapid conversion to tryptophol and indole lactic acid, two metabolites produced in vitro by T. brucei gambiense [4].
• Reaction of one-electron oxidant (Br(2)(*-)) with tryptophol (TP) and 5-hydroxytryptophol (HTP) have been studied in aqueous solution in the pH range from 3 to 10, employing nanosecond pulse radiolysis technique and the transients detected by kinetic spectrophotometry [5].
• Radioimmunoassay of 5-methoxy tryptophol in sheep plasma and pineal glands [6].
• Determination of endogeneous indoleacetic acid and tryptophol in mouse brain by high performance liquid chromatography with fluorometric detection [7].

Biological context of Tryptophol

• Daily administration of tryptophol to laboratory rodents resulted in significantly depressed antibody production of heterologous red blood cell challenge, did not alter cellular-mediated responses to oxazalone [2].

Analytical, diagnostic and therapeutic context of Tryptophol

• More than 85% of the radioactivity remaining in brain 2-5 min after intravenous injection co-migrated with tryptophol standards when analyzed by thin-layer chromatography [3].
• The effects of tryptophol on immune responses and it implications toward trypanosome-induced immunosuppression [2].

References