Disease relevance of Hydroxytryptophol

• Of the compounds tested, hydroxytryptophan, N-acetylserotonin, hydroxytryptophol, and their corresponding methoxyindoles all caused a marked hypothermia, indicating that several indolic products may be involved in thermoregulation [1].
• Detection of relapses in alcohol-dependent patients: comparison of carbohydrate-deficient transferrin in serum, 5-hydroxytryptophol in urine, and self-reports [2].
• Elevated brain 5-hydroxytryptophol levels in experimental portal-systemic encephalopathy [3].

Psychiatry related information on Hydroxytryptophol

• The ratio of 5-hydroxytryptophol to 5-hydroxyindole-3-acetic acid (5HTOL/5HIAA) in urine was compared with concentrations of ethanol and methanol as a way to monitor recent alcohol consumption [4].
• Blood and urine samples were examined for carbohydrate-deficient transferrin (CDT) and 5-hydroxytryptophol (5-HTOL), markers of excess alcohol intake, and urine-benzodiazepines (u-Benz), a marker of drug abuse [5].

High impact information on Hydroxytryptophol

• A functional role for 5-hydroxytryptophol as a neuromodulator, possibly associated with diffuse neuroendocrine function (amine precursor, uptake and decarboxylation, APUD) is suggested [6].
• Investigation of circadian rhythms for pineal 5-hydroxytryptophol and other indoles in the rat [7].
• Basal lipolysis was inhibited by all the indoles tested at a dose of 1 mumole except hydroxytryptophol [8].
• In healthy subjects, hereditary factors seemed to have little influence on the CSF level of 5-hydroxytryptophol [9].
• In addition, tissue concentrations of 5-HT, 5-hydroxyindole-3-acetic acid and 5-hydroxytryptophol were measured by high-performance liquid chromatography with electrochemical detection in these neostriatal divisions [10].

Chemical compound and disease context of Hydroxytryptophol

• AIMS: To review the mechanism behind the alcohol-induced shift in serotonin metabolism, and the use of urinary 5-hydroxytryptophol (5-HTOL) as a biochemical marker of acute alcohol consumption [11].
• CONCLUSION:: Determination of 5-hydroxytryptophol glucuronide by ELISA offers promising results in detection of previous alcohol consumption [12].
• AIMS: This study investigated the stability and reproducibility of urinary ethyl glucuronide (EtG) and the 5-hydroxytryptophol (5-HTOL) to 5-hydroxyindole-3-acetic acid (5-HIAA) ratio, both of which are used as biochemical markers of recent alcohol consumption, after single and multiple oral doses of ethanol in healthy human subjects [13].

Biological context of Hydroxytryptophol

• N-acetylserotonin, serotonin, 5-hydroxytryptophol and 5-methoxytryptophol did not influence sexual maturation either when injected in the morning or in the afternoon [14].
• One electron oxidation induced dimerization of 5-hydroxytryptophol: role of 5-hydroxy substitution [15].
• Day and night rhythms in the methylation of N-acetylserotonin/5-hydroxytryptophol in the pineal gland of males rats of different ages [16].
• Possible new biomarkers include minor ethanol metabolites (protein-acetaldehyde condensates and associated autoimmune responses, ethylglucuronide, and phosphatidylethanolamine), 5-hydroxytryptophol, and genetic markers although so far their routine applications have been limited [17].

Anatomical context of Hydroxytryptophol

• 5-Hydroxytryptophol (5-HTOL) caused a dose-dependent contraction of helically-cut strips of dog cerebral arteries [18].
• 5-hydroxytryptophol in the cerebrospinal fluid and urine of alcoholics and healthy subjects [19].
• Using a simple high performance liquid chromatographic method, we measured melatonin, N-acetyl-5-hydroxytryptamine (NAc-5HT), 5-hydroxytryptophol (5HTOL), 5-hydroxyindoleacetic acid (5HIAA), 5-hydroxytryptamine (5HT) and tryptophan in single rat pineal glands [20].

Associations of Hydroxytryptophol with other chemical compounds

• This study compared urinary 5-hydroxytryptophol (5HTOL) with breath-ethanol testing as objective ways to disclose recent drinking by outpatients attending a methadone maintenance treatment clinic [21].
• Reaction of one-electron oxidant (Br(2)(*-)) with tryptophol (TP) and 5-hydroxytryptophol (HTP) have been studied in aqueous solution in the pH range from 3 to 10, employing nanosecond pulse radiolysis technique and the transients detected by kinetic spectrophotometry [15].
• Serotonin was also metabolized to 5-hydroxytryptophol and 5-hydroxyindole acetic acid, probably through stepwise transformation catalyzed by monoamine oxidase, aldehyde dehydrogenase and aldehyde reductase [22].
• In pineals of 10 day old rats 5-hydroxytryptophan, 5-hydroxyindole-3-acetic acid, N-acetylserotonin/5-hydroxytryptophol and norepinephrine are methylated following a circadian rhythm [23].
• RESULTS:: 5-Hydroxytryptophol glucuronide was measured by ELISA with good analytical precision, its diagnostic specificity and sensitivity was better than that of 5-hydroxytryptophol and its correlation was closer to ethyl glucuronide than to 5-hydroxytryptophol [12].

Analytical, diagnostic and therapeutic context of Hydroxytryptophol

• Determination of glucuronidated 5-hydroxytryptophol (GTOL), a marker of recent alcohol intake, by ELISA technique [12].
• The aim of the present study was to develop a high-performance liquid chromatographic (HPLC) method for determination of the serotonin metabolite 5-hydroxytryptophol (5HTOL) in human urine [24].
• Sixteen out of 23 patients receiving drug therapy showed elevated excretion of 5-hydroxytryptophol [25].

References