Disease relevance of Isoxanthopterin

• Human mammary carcinoma MCF-7 cell line responsiveness to the pteridines xanthopterin and isoxanthopterin was studied using the MTS assay for measurement of cell viability [1].

Psychiatry related information on Isoxanthopterin

• We have found normal concentrations of neopterin, monapterin, isoxanthopterin, biopterin and pterin in the urine of 10 patients with Rett syndrome, and normal values for total biopterin and neopterin in the blood of 4 subjects [2].

High impact information on Isoxanthopterin

• An assay for human plasma xanthine oxidase activity was developed with pterin as the substrate and the separation of product (isoxanthopterin) by high-performance liquid chromatography with a fluorescence detector [3].
• The five pigments 1-5 and a colorless substance 6 were present in the dorsal skin of frogs of nine selected species belonging to Rhacophoridae, Ranidae, Hylidae, and Bufonidae and were identified as pterin-6-carboxylic acid, xanthopterin, isoxanthopterin, erythro-biopterin, 6-hydroxymethylpterin, and guanine, respectively [4].
• Characterization of an isoxanthopterin binding protein from Oncopeltus fasciatus [5].
• Biopterin, isoxanthopterin and 6-pterincarboxylic acid were identified in the head of the malaria vector mosquito Anopheles albimanus Weidemann (Diptera: Culicidae) by HPLC [6].
• Urine excretion of pterin and isoxanthopterin was measured by HPLC [7].

Gene context of Isoxanthopterin

• Evidence was obtained for the in vivo involvement of xanthine dehydrogenase in the conversion of pterin to isoxanthopterin [7].

References