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Chemical Compound Review:

Sweroside (1S,9S,10S)-10-ethenyl-9- [(2S,3R,4S,5S,6R)...

Synonyms: CHEMBL456137, SureCN307117, KST-1A1919, KST-1A1920, MEGxp0_000813, ...

Kumarasamy, Y. et al., Oztürk, N. et al., Horn, M.M. et al.

Oztürk, Korkmaz, Oztürk, Başer,

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Disease relevance of Sweroside

Swertiamarin and sweroside exhibited significant general toxicity in brine shrimp lethality bioassay and the LD50 values were 8.0 microg/ml and 34 microg/ml, respectively, whereas that of the positive control podophyllotoxin, a well known cytotoxic lignan, was 2.79 microg/ml [1].

High impact information on Sweroside

Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts [2].
Transformation of naturally-occurring 1,9-trans-9,5-cis sweroside to all trans sweroside during acetylation of sweroside aglycone [3].
Pure sweroside was converted to the sweroside aglycone 1-acetoxy derivative (DABCO/Ac2O) after hydrolysis of the glucose unit [3].
From the rootstock of Scabiosa columbria L. loganin and sweroside were isolated [3].
As part of our on-going search for bioactive compounds from Scottish plants, two secoiridoid glycosides, swertiamarin and sweroside, have been isolated from the aerial parts of Centaurium erythraea Rafn (Family: Gentianaceae) by reversed-phase preparative HPLC coupled with a photo-diode-array detector [1].

Biological context of Sweroside

Wound healing properties of Gentian (Gentiana lutea ssp. symphyandra) extract and its main constituents, gentiopicroside, sweroside and swertiamarine (compounds 1-3, respectively) were evaluated by comparison with dexpanthenol on cultured chicken embryonic fibroblasts [2].

References

Bioactivity of secoiridoid glycosides from Centaurium erythraea. Kumarasamy, Y., Nahar, L., Cox, P.J., Jaspars, M., Sarker, S.D. Phytomedicine (2003) [Pubmed]
Effects of gentiopicroside, sweroside and swertiamarine, secoiridoids from gentian (Gentiana lutea ssp. symphyandra), on cultured chicken embryonic fibroblasts. Oztürk, N., Korkmaz, S., Oztürk, Y., Başer, K.H. Planta Med. (2006) [Pubmed]
Transformation of naturally-occurring 1,9-trans-9,5-cis sweroside to all trans sweroside during acetylation of sweroside aglycone. Horn, M.M., Drewes, S.E., Brown, N.J., Munro, O.Q., Meyer, J.J., Mathekga, A.D. Phytochemistry (2001) [Pubmed]

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