Disease relevance of piperidine-2,3-dicarboxylic acid

• 4. General glutamate antagonists such as cis-2,3-piperidine dicarboxylic acid (PDA) and kynurenic acid blocked the light input to all ganglion cells [1].
• Myoclonus or convulsions occurred at various times after the intraventricular injection of cis-2,3-piperidine dicarboxylic acid, trans-2,3-, cis-2,4-, cis-2,5- and cis-2,6-, piperidine dicarboxylic acids, and after the intraperitoneal injection of trans-2,3-piperidine dicarboxylic acid [2].
• The onset pressures for the tremor, myoclonus and convulsions seen in the high pressure neurological syndrome (HPNS) are increased following cis-2,3-piperidine dicarboxylic acid 1 mmol/kg in the rat [3].

High impact information on piperidine-2,3-dicarboxylic acid

• Finally, a combination of APB and cis-2,3 piperidine dicarboxylic acid (PDA) was used to isolate the contributions from the cone photoreceptors [4].
• 6. The C-cell light response was modified in two stages by cis-2,3-piperidine dicarboxylic acid (cis-PDA; 0.5-5 mM): first the depolarizing response disappeared; then the membrane potential hyperpolarized concomitant with a large reduction or elimination of the hyperpolarizing light response [5].
• The cortical-evoked activation of subthalamic nucleus neurons was reversibly suppressed by kynurenic acid and cis-2,3-piperidine dicarboxylic acid, two broad-spectrum antagonists of excitatory amino acids, microiontophoretically applied at doses which also blocked excitations induced by N-methyl-D-aspartic, quisqualic and kainic acids [6].
• Intravitreal 4-phosphono-butyric acid (APB) and cis-2,3-piperidine-dicarboxylic acid (PDA) were applied to isolate the photoreceptor response [7].
• Electroretinograms were recorded for 23 monochromatic stimuli (400-700 nm) at an equal energy with white light adaptation before and after treatment with the glutamate analogues, 2-amino-4-phosphonobutyric acid, cis -2,3-piperidine-dicarboxylic acid, or both [8].

Anatomical context of piperidine-2,3-dicarboxylic acid

• Response of lamina V medullary dorsal horn neurons to noxious thermal and noxious mechanical facial stimuli were challenged with iontophoretically applied cis-2,3-piperidine dicarboxylic acid, a broad spectrum excitatory amino acid antagonist [9].

Associations of piperidine-2,3-dicarboxylic acid with other chemical compounds

• The interaction between drugs which affect ON and OFF responses to light and ocular growth was investigated in 154 eyes of newly-hatched chicks raised with normal vision or monocular occlusion with regular intravitreal injections of APB (2-amino-4 phosphonobutyric acid) or PDA (cis 2,3-piperidine-dicarboxylic acid) [10].

Gene context of piperidine-2,3-dicarboxylic acid

• Injection in the SN of the non-NMDA receptor agonist AMPA and the NMDA receptor agonist PDA increased the development of high helium pressure-induced myoclonia, whereas injection of the NMDA receptor antagonist AP-7 into the SN or the GP decreased it [11].

Analytical, diagnostic and therapeutic context of piperidine-2,3-dicarboxylic acid

• Protection against sound-induced seizures occurred after intraperitoneal injection of (+/-)cis-2,3-piperidine dicarboxylic acid (0.52-1.8 mmol/kg) [2].

References