Disease relevance of NSC30079

• When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge [1].
• The D,L or L forms of 2-amino-4-phosphonobutyric acid (AP4), but not D-AP4, significantly enhanced [3H]IP levels to approximately 135% of basal values.(ABSTRACT TRUNCATED AT 250 WORDS)[2]

Psychiatry related information on NSC30079

• 2-Amino-4-phosphonobutyric acid selectively blocks two-way avoidance learning in the mouse [3].

High impact information on NSC30079

• 2-Amino-4-phosphonobutyric acid blocks the light response of the ON bipolar cell by mimicking the endogenous photoreceptor transmitter [1].
• Spikes were determined to be Ca2+ action potentials triggered at the axon terminal and were abolished by 2-amino-4-phosphonobutyric acid (APB), an agonist that mimics glutamate [4].
• We studied this relationship in postnatal tree shrews either by completely blocking retinal ganglion cell activity with TTX or by selectively blocking activity to the developing ON-center LGN layers (1 and 2) with 2-amino-4-phosphonobutyric acid (APB), using unilateral and bilateral eye injections [5].
• Either the pharmacological agents Co2+, Mg2+, and low Ca2+, known to block calcium-dependent synaptic transmission or 2-amino-4-phosphonobutyric acid (APB), which blocks transmission in the ON pathway, were added to the solution perfusing the retina [6].
• The predominant site (74% of the total) had characteristics similar to the Cl(-)-dependent binding site in forebrain membranes [i.e., Ki values of 5.7 +/- 1.4 microM and 119 +/- 38 nM for 2-amino-4-phosphonobutyric acid (AP4) and quisqualic acid, (QUIS), respectively] [7].

Biological context of NSC30079

• A smaller (-27%) decrease in the magnitude of pressor response elicited by muscular contraction was produced by intrathecal administration of 2-amino-4-phosphonobutyric acid which acts on a presynaptic EAA receptor [8].

Anatomical context of NSC30079

• The similarity of the electrical effects of L-alpha-aminoadipic acid and 2-amino-4-phosphonobutyric acid suggests that the initial loss of the b-wave following L-alpha-aminoadipic acid treatment is due to action of the amino acid at a synaptic site via a mechanism distinct from that which causes subsequent histological damage to the glial cells [9].
• The binding of DL-[3,4-3H] 2-amino-4-phosphonobutyric acid DL[3H]-APB to rat whole brain synaptic membranes was investigated [10].
• Suppressing action of 2-amino-4-phosphonobutyric acid on mossy fiber-induced excitation in the guinea pig hippocampus [11].
• Four monomethyl-substituted analogues of 2-amino-4-phosphonobutanoic acid (APB), an antagonist of excitatory pathways in the central nervous system, were prepared in order to investigate the steric requirements of the APB receptor [12].
• Activity of the conformationally rigid 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid (cyclobutylene AP5) on evoked responses in the perforant pathway of rat hippocampus [13].

Associations of NSC30079 with other chemical compounds

• The spectral response was also examined after applying APB (2-amino-4-phosphonobutyric acid), in the presence of dopamine included to avoid polysynaptic effects of APB [14].
• Nitric oxide, 2-amino-4-phosphonobutyric acid and light/dark adaptation modulate short-wavelength-sensitive synaptic transmission to retinal horizontal cells [15].

Gene context of NSC30079

• In the past, the absence of useful 2-amino-4-phosphonobutanoic acid (AP4) analogues has hampered the pharmacological study and comparison of different systems which are sensitive to L-AP4 [16].
• The action of 2-amino-4-phosphonobutyric acid (APB) on mossy fiber-induced excitation in CA3 neurons was studied in vitro with thin sections of guinea pig hippocampus [11].

Analytical, diagnostic and therapeutic context of NSC30079

• 1. In this report we describe extracellular recordings made from directionally selective (DS) ganglion cells in the rabbit retina during perfusion with 2-amino-4-phosphonobutyric acid (APB) to block ON channels through the retina [17].

References