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Chemical Compound Review

L-APB     2-amino-4-phosphono-butanoic acid

Synonyms: ap-4, CHEMBL285843, Bio-0264, AG-E-48399, AG-G-34286, ...
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Disease relevance of NSC30079

  • When intracellular electrophysiological recordings were obtained from the perfused retina-eyecup preparation of the mud-puppy (Necturus maculosus), the addition of 2-amino-4-phosphonobutyric acid to the bathing medium blocked all responses in the ON channel but left intact the OFF responses including OFF ganglion cell discharge [1].
  • The D,L or L forms of 2-amino-4-phosphonobutyric acid (AP4), but not D-AP4, significantly enhanced [3H]IP levels to approximately 135% of basal values.(ABSTRACT TRUNCATED AT 250 WORDS)[2]

Psychiatry related information on NSC30079


High impact information on NSC30079


Biological context of NSC30079


Anatomical context of NSC30079


Associations of NSC30079 with other chemical compounds


Gene context of NSC30079


Analytical, diagnostic and therapeutic context of NSC30079


  1. 2-amino-4-phosphonobutyric acid: a new pharmacological tool for retina research. Slaughter, M.M., Miller, R.F. Science (1981) [Pubmed]
  2. Excitatory amino acid agonist-antagonist interactions at 2-amino-4-phosphonobutyric acid-sensitive quisqualate receptors coupled to phosphoinositide hydrolysis in slices of rat hippocampus. Schoepp, D.D., Johnson, B.G. J. Neurochem. (1988) [Pubmed]
  3. 2-Amino-4-phosphonobutyric acid selectively blocks two-way avoidance learning in the mouse. Sahai, S., Buselmaier, W., Brussmann, A. Neurosci. Lett. (1985) [Pubmed]
  4. Light evokes Ca2+ spikes in the axon terminal of a retinal bipolar cell. Protti, D.A., Flores-Herr, N., von Gersdorff, H. Neuron (2000) [Pubmed]
  5. The effect of altered neuronal activity on the development of layers in the lateral geniculate nucleus. Casagrande, V.A., Condo, G.J. J. Neurosci. (1988) [Pubmed]
  6. Evidence in support of a photoreceptoral origin for the "light-peak substance". Gallemore, R.P., Griff, E.R., Steinberg, R.H. Invest. Ophthalmol. Vis. Sci. (1988) [Pubmed]
  7. Characterization of L-glutamate binding sites in rat spinal cord synaptic membranes: evidence for multiple chloride ion-dependent sites. Mena, E.E., Pagnozzi, M.J., Gullak, M.F. J. Neurochem. (1986) [Pubmed]
  8. An excitatory amino acid synapse in the thoracic spinal cord is involved in the pressor response to muscular contraction. Bauer, R.M., Nolan, P.C., Horn, E.M., Waldrop, T.G. Brain Res. Bull. (1993) [Pubmed]
  9. A comparison of the effects of isomers of alpha-aminoadipic acid and 2-amino-4-phosphonobutyric acid on the light response of the müller glial cell and the electroretinogram. Zimmerman, R.P., Corfman, T.P. Neuroscience (1984) [Pubmed]
  10. Characterization of the binding of DL-[3H]-2-amino-4-phosphonobutyrate to L-glutamate-sensitive sites on rat brain synaptic membranes. Butcher, S.P., Collins, J.F., Roberts, P.J. Br. J. Pharmacol. (1983) [Pubmed]
  11. Suppressing action of 2-amino-4-phosphonobutyric acid on mossy fiber-induced excitation in the guinea pig hippocampus. Yamamoto, C., Sawada, S., Takada, S. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1983) [Pubmed]
  12. Antagonist activity of methyl-substituted analogues of 2-amino-4-phosphonobutanoic acid in the hippocampal slice. Crooks, S.L., Freund, R.K., Halsrud, D.A., Koerner, J.F., Johnson, R.L. Brain Res. (1985) [Pubmed]
  13. Activity of the conformationally rigid 2-amino-4-phosphonobutanoic acid (AP4) analogue (RS)-1-amino-3-(phosphonomethylene)cyclobutane-1-carboxylic acid (cyclobutylene AP5) on evoked responses in the perforant pathway of rat hippocampus. Peterson, N.L., Kroona, H.B., Johnson, R.L., Koerner, J.F. Brain Res. (1992) [Pubmed]
  14. Dopamine and 2-amino-4-phosphonobutyrate differentially modify spectral responses of H1 horizontal cells in carp retina. Yasui, S., Yamada, M., Djamgoz, M.B. Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale. (1990) [Pubmed]
  15. Nitric oxide, 2-amino-4-phosphonobutyric acid and light/dark adaptation modulate short-wavelength-sensitive synaptic transmission to retinal horizontal cells. Furukawa, T., Yamada, M., Petruv, R., Djamgoz, M.B., Yasui, S. Neurosci. Res. (1997) [Pubmed]
  16. Characterization of retinal and hippocampal L-AP4 receptors using conformationally constrained AP4 analogues. Peterson, N.L., Thoreson, W.B., Johnson, R.L., Koerner, J.F., Miller, R.F. Brain Res. (1991) [Pubmed]
  17. Effect of ON pathway blockade on directional selectivity in the rabbit retina. Kittila, C.A., Massey, S.C. J. Neurophysiol. (1995) [Pubmed]
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