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Chemical Compound Review

CHEMBL247368     (2S)-2-[[(2S)-2-[2-[2-[[(2S)- 2-amino-3-(4...

Synonyms: CHEBI:510309, CTK2F3118, DNC007954, AR-1J3473, AC1L3X5D, ...
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Disease relevance of Enkephalinamide-met-


High impact information on Enkephalinamide-met-


Anatomical context of Enkephalinamide-met-

  • The effects of Met-enkephalinamide (MET-ENKamide) on brain temperature (Tb) and metabolic rate (MR) were assessed following direct administration into the preoptic/anterior hypothalamus (PO/AH) of freely moving rats [4].

Analytical, diagnostic and therapeutic context of Enkephalinamide-met-

  • Repetitive electrical stimulation of the superficial peroneal (SP) and posterior tibial (PT) nerves inhibited these nociceptive discharges as well as systemic administration of met-enkephalinamide (synthetic endorphin) [6].


  1. Vagal bradycardia produced by microinjections of morphine-like drugs into the nucleus ambiguus in anaesthetized dogs. Laubie, M., Schmitt, H., Vincent, M. Eur. J. Pharmacol. (1979) [Pubmed]
  2. Degradation of enkephalin and enkephalinamide by neuroblastoma x glioma hybrid cells as studied by 13C n.m.r. Deslauriers, R., Jarrell, H.C., Griffith, D.W., McGregor, W.H., Smith, I.C. Int. J. Pept. Protein Res. (1980) [Pubmed]
  3. Opioid peptides in the nervous system of Aplysia: a combined biochemical, immunocytochemical, and electrophysiological study. Carpenter, D.O., Kemenes, G., Elekes, K., Leung, M., Stefano, G., Rózsa, K.S., Salánki, J. Cell. Mol. Neurobiol. (1995) [Pubmed]
  4. Changes in body temperature and metabolic rate following microinjection of Met-enkephalinamide in the preoptic/anterior hypothalamus of rats. Stanton, T.L., Sartin, N.F., Beckman, A.L. Regul. Pept. (1985) [Pubmed]
  5. Effect of opioid peptides on gonadotrophin secretion. Motta, M., Martini, L. Acta Endocrinol. (1982) [Pubmed]
  6. Endorphins: mechanism of acupuncture analgesia. Sodipo, J.O., Gilly, H., Pauser, G. Am. J. Chin. Med. (1981) [Pubmed]
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