Disease relevance of Enkephalinamide-met-

• The site in the dog medulla oblongata where fentanyl or met-enkephalinamide produced vagal bradycardia was determined using microinjections [1].
• 13C n.m.r. and thin-layer chromatography were used to monitor the degradation of methionine-enkephalinamide in the presence of neuroblastoma x glioma hybrid cells (NG 108-15) and membranes [2].

High impact information on Enkephalinamide-met-

• 2. Binding studies using 3H-D-Ala2, met-enkephalinamide (3H-DAMA) showed a single class of high-affinity binding sites with a Kd of 1.3 nM and a binding density of 45 pmol/g. 3 [3].
• Changes in body temperature and metabolic rate following microinjection of Met-enkephalinamide in the preoptic/anterior hypothalamus of rats [4].
• The synthetic Met-Enk agonistic analogue [D-Ala2] methionine-Enkephalinamide ([D-Ala2]Met-Enk) also enhances significantly serum LH levels at 30 and 60 min; under the same experimental conditions neither Met-Enk nor [D-Ala2]Met-Enk modifies serum levels of FSH following intraventricular injections into ovariectomized animals [5].

Anatomical context of Enkephalinamide-met-

• The effects of Met-enkephalinamide (MET-ENKamide) on brain temperature (Tb) and metabolic rate (MR) were assessed following direct administration into the preoptic/anterior hypothalamus (PO/AH) of freely moving rats [4].

Analytical, diagnostic and therapeutic context of Enkephalinamide-met-

• Repetitive electrical stimulation of the superficial peroneal (SP) and posterior tibial (PT) nerves inhibited these nociceptive discharges as well as systemic administration of met-enkephalinamide (synthetic endorphin) [6].

References