Chemical Compound Review:
norketamine 2-amino-2-(2- chlorophenyl)cyclohexan-1-one
Synonyms:
CHEMBL1039, AGN-PC-00FX4J, SureCN3390132, CTK8D6626, AR-1D8132, ...
- Ketamine and midazolam kinetics during continuous hemodiafiltration in patients with multiple organ dysfunction syndrome. Tsubo, T., Sakai, I., Okawa, H., Ishihara, H., Matsuki, A. Intensive care medicine. (2001)
- Characterization of the stereoselective biotransformation of ketamine to norketamine via determination of their enantiomers in equine plasma by capillary electrophoresis. Theurillat, R., Knobloch, M., Levionnois, O., Larenza, P., Mevissen, M., Thormann, W. Electrophoresis (2005)
- HPLC determination of ketamine, norketamine, and dehydronorketamine in plasma with a high-purity reversed-phase sorbent. Bolze, S., Boulieu, R. Clin. Chem. (1998)
- Stereoselective pharmacokinetics of ketamine and norketamine after racemic ketamine or S-ketamine administration during isoflurane anaesthesia in Shetland ponies. Larenza, M.P., Landoni, M.F., Levionnois, O.L., Knobloch, M., Kronen, P.W., Theurillat, R., Schatzmann, U., Thormann, W. British journal of anaesthesia (2007)
- Effects of protein calorie malnutrition on the pharmacokinetics of ketamine in rats. Williams, M.L., Mager, D.E., Parenteau, H., Gudi, G., Tracy, T.S., Mulheran, M., Wainer, I.W. Drug Metab. Dispos. (2004)
- Contribution of CYP3A4, CYP2B6, and CYP2C9 isoforms to N-demethylation of ketamine in human liver microsomes. Hijazi, Y., Boulieu, R. Drug Metab. Dispos. (2002)
- Oral ketamine is antinociceptive in the rat formalin test: role of the metabolite, norketamine. Shimoyama, M., Shimoyama, N., Gorman, A.L., Elliott, K.J., Inturrisi, C.E. Pain (1999)
- Rectal ketamine for induction of anaesthesia in children. Idvall, J., Holasek, J., Stenberg, P. Anaesthesia. (1983)
- Carbon-11 labelled ketamine-synthesis, distribution in mice and PET studies in baboons. Shiue, C.Y., Vallabhahosula, S., Wolf, A.P., Dewey, S.L., Fowler, J.S., Schlyer, D.J., Arnett, C.D., Zhou, Y.G. Nucl. Med. Biol. (1997)
- Detection of acid-labile conjugates of ketamine and its metabolites in urine samples collected from pub participants. Lin, H.R., Lua, A.C. Journal of analytical toxicology. (2004)
- Tissue uptake of ketamine and norketamine enantiomers in the rat: indirect evidence for extrahepatic metabolic inversion. Edwards, S.R., Mather, L.E. Life Sci. (2001)
- Ketamine and midazolam decrease cerebral blood flow and consequently their own rate of transport to the brain: an application of mass balance pharmacokinetics with a changing regional blood flow. Björkman, S., Akeson, J., Nilsson, F., Messeter, K., Roth, B. Journal of pharmacokinetics and biopharmaceutics. (1992)
- Detection of ketamine and norketamine in urine of nonhuman primates after a single dose of ketamine using microplate enzyme-linked immunosorbent assay (ELISA) and NCI-GC-MS. Negrusz, A., Adamowicz, P., Saini, B.K., Webster, D.E., Juhascik, M.P., Moore, C.M., Schlemmer, R.F. Journal of analytical toxicology. (2005)
- Effect of oral ketamine on secondary hyperalgesia, thermal and mechanical pain thresholds, and sedation in humans. Mikkelsen, S., Jørgensen, H., Larsen, P.S., Brennum, J., Dahl, J.B. Regional anesthesia and pain medicine. (2000)
- Role of chiral chromatography in therapeutic drug monitoring and in clinical and forensic toxicology. Williams, M.L., Wainer, I.W. Therapeutic drug monitoring. (2002)
- Pharmacokinetics and analgesic effects of i.m. and oral ketamine. Grant, I.S., Nimmo, W.S., Clements, J.A. British journal of anaesthesia. (1981)
- On-line preconcentration and determination of ketamine and norketamine by micellar electrokinetic chromatography. Complementary method to gas chromatography/mass spectrometry. Jen, H.P., Tsai, Y.C., Su, H.L., Hsieh, Y.Z. Journal of chromatography. A. (2006)
- Ketamine and norketamine plasma concentrations after i.v., nasal and rectal administration in children. Malinovsky, J.M., Servin, F., Cozian, A., Lepage, J.Y., Pinaud, M. British journal of anaesthesia. (1996)
- Use of SPE and LC/TIS/MS/MS for rapid detection and quantitation of ketamine and its metabolite, norketamine, in urine. Wang, K.C., Shih, T.S., Cheng, S.G. Forensic Sci. Int. (2005)