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Chemical Compound Review

gammaGluCys     (2S)-2-amino-4-[[(1S)-1- carboxy-2-sulfanyl...

Synonyms: gamma-Glu-cys, CHEMBL460831, CHEBI:17515, HMDB01049, Glu(-Cys), ...
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Disease relevance of gamma-L-glutamyl-L-cysteine


High impact information on gamma-L-glutamyl-L-cysteine

  • Further, as demonstrated by the facility of AtPCS1 for the net synthesis of S-alkyl-PCs from S-alkylglutathiones with biphasic kinetics, consistent with the sufficiency of S-alkylglutathiones as both gamma-Glu-Cys donors and acceptors in media devoid of metals, even heavy metal thiolates are dispensable [2].
  • Furthermore, gamma-Glu-Cys was at least as good as GSH in protecting yeast cells against an oxidant challenge, providing the first evidence that gamma-Glu-Cys can act as an antioxidant and substitute for GSH in a eukaryotic cell [3].
  • These results suggest that the loop covers the active site while ATP and gamma-Glu-Cys bind there and that it protects the unstable gamma-Glu-Cys phosphate intermediate from decomposition by bulk water.(ABSTRACT TRUNCATED AT 250 WORDS)[4]
  • The gamma-glutamylcysteine synthetase (gamma-ECS) catalyzes the synthesis of the dipeptidethiol gamma-glu-cys (gamma-EC), the first step in the biosynthesis of phytochelatins (PCs) [5].
  • The synthesis of phytochelatins (PC), intracellular metal-binding polypeptides characterized by a repeating sequence of gamma-glutamic acid- cysteine (gamma-Glu-Cys) pairs, has been studied in laboratory cultures of the marine diatom Phaeodactylum tricornutum exposed to Cd, Pb or Zn [6].

Analytical, diagnostic and therapeutic context of gamma-L-glutamyl-L-cysteine


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