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Chemical Compound Review

Brinaldix     4-chloro-N-[(2R,6S)-2,6- dimethyl-1...

Synonyms: Brinedine, Clopamida, Adurix, Clopamidum, Aquex, ...
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Disease relevance of clopamide

  • In the treatment of mild-to-moderate hypertension, a low-dose combination of reserpine and clopamide once a day is considerably more effective than, and as tolerable as, 5-10 mg of enalapril once a day [1].
  • The diuretics cyclopenthiazide, spironolactone and clopamide given prophylactically to high weight gain primigravidae did not prevent the onset of proteinuric pre-eclampsia, but caused the babies to be lighter in weight than those of controls [2].

High impact information on clopamide


Chemical compound and disease context of clopamide


Biological context of clopamide

  • Eight male patients, aged 36-59 and with an average supine diastolic pressure of 95-115 mm Hg, were treated with single daily doses of clopamide 5 mg as monotherapy for 16 weeks [9].

Associations of clopamide with other chemical compounds

  • Two fixed combinations of beta-blockers and diuretics, penbutolol plus furosemide and pindolol plus clopamide, were compared with respect to efficacy, safety, and tolerability in hypertensive out-patients [10].
  • 1.0 mM furosemide, 0.1 mM spironolactone, 0.01 mM clopamide and 0.8 mM acetazolamide did not change the reaction to ADH [11].
  • The reserpine/ clopamide and enalapril groups did not differ with regard to demographic and baseline characteristics (mean age 57 or 58 years, respectively; 63% or 56% males, respectively; mean SBP/DBP after the 2-week placebo period = 156 mmHg/104 mmHg in both groups) [1].

Analytical, diagnostic and therapeutic context of clopamide


  1. Low-dose reserpine/thiazide combination in first-line treatment of hypertension: efficacy and safety compared to an ACE inhibitor. Griebenow, R., Pittrow, D.B., Weidinger, G., Mueller, E., Mutschler, E., Welzel, D. Blood Press. (1997) [Pubmed]
  2. The relevance of hypertension and oedema in pregnancy. MacGillivray, I., Campbell, D.M. Clinical and experimental hypertension. (1980) [Pubmed]
  3. New design for clinical trial of antihypertensive drugs applied to pindolol, clopamide, and combinations thereof. Nyberg, G., Asplund, J., Anagreus, N., Aström, B., Leppert, J., Bergström, R., Overmo, J., Kullman, S., Lessem, J. Lancet (1982) [Pubmed]
  4. Clopamide: plasma concentrations and diuretic effect in humans. McNeil, J.J., Conway, E.L., Drummer, O.H., Howes, L.G., Christophidis, N., Louis, W.J. Clin. Pharmacol. Ther. (1987) [Pubmed]
  5. Gas-liquid chromatography-mass spectroscopy determination of clopamide in plasma. Stüber, W., Blume, H., Sörgel, F., Stenzhorn, G. Journal of pharmaceutical sciences. (1989) [Pubmed]
  6. Interaction of cyclosporine-A with the renin-angiotensin system in canine veins. Müller-Schweinitzer, E. Naunyn Schmiedebergs Arch. Pharmacol. (1989) [Pubmed]
  7. Inhibition of the Cl-/NaCO3- anion exchanger by xipamide in human red blood cells. Nazaret, C., Diez, J., Hannaert, P.A., Christen, M.O., Wierzbicki, N., Garay, R.P. Eur. J. Pharmacol. (1987) [Pubmed]
  8. A dose-finding study of the combination of pindolol, clopamide and endralazine in the treatment of moderate-to-severe hypertension. Seedat, Y.K., Rawat, R. S. Afr. Med. J. (1984) [Pubmed]
  9. Effect of clopamide, a thiazide diuretic, on copper and zinc levels in hypertensive patients. du Preez, M.J., Lockett, C.J. Journal of the American College of Nutrition. (1991) [Pubmed]
  10. Serum potassium and body weight during treatment with two fixed combinations of beta-blockers and diuretics in hypertensive patients: a controlled study. Houtzagers, J.J., Sumajow, C.A., Chadha, D.R. Clinical therapeutics. (1986) [Pubmed]
  11. The effect of diuretics and vasopressin on the osmotic permeability of the frog urinary bladder. Natochin, Y.V., Shakhmatova, E.I. Physiologia Bohemoslovaca. (1976) [Pubmed]
  12. The effect of once daily beta-adrenoceptor blocker-thiazide diuretic combination on the ambulatory blood pressure. Gould, B.A., Hornung, R.S., Kieso, H., Mann, S., Raftery, E.B. British journal of clinical pharmacology. (1982) [Pubmed]
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