Disease relevance of clopamide

• In the treatment of mild-to-moderate hypertension, a low-dose combination of reserpine and clopamide once a day is considerably more effective than, and as tolerable as, 5-10 mg of enalapril once a day [1].
• The diuretics cyclopenthiazide, spironolactone and clopamide given prophylactically to high weight gain primigravidae did not prevent the onset of proteinuric pre-eclampsia, but caused the babies to be lighter in weight than those of controls [2].

High impact information on clopamide

• New design for clinical trial of antihypertensive drugs applied to pindolol, clopamide, and combinations thereof [3].
• Clopamide pharmacokinetics were determined after oral doses of 5, 10, and 20 mg in normal volunteers [4].
• A gas-liquid chromatography-mass spectroscopy (GLC-MS) method for the determination of clopamide (1) in human plasma was developed to evaluate the pharmacokinetics and bioavailability of 1 in humans [5].
• Systemic i.v. infusion of the renin inhibitor H-77 (0.1 mg/kg/h) reversed the inhibition of bradykinin by both clopamide and cyclosporine-A [6].
• Clopamide only inhibited the anion exchanger at high concentrations (IC50 of about 10(-3) M) [7].

Chemical compound and disease context of clopamide

• A dose-finding study of the combination of pindolol, clopamide and endralazine in the treatment of moderate-to-severe hypertension [8].
• The concept of initiating treatment of mild-to-moderate hypertension with a low-dose combination of reserpine and the thiazide clopamide in comparison to monotherapy with an ACE inhibitor was investigated [1].

Biological context of clopamide

• Eight male patients, aged 36-59 and with an average supine diastolic pressure of 95-115 mm Hg, were treated with single daily doses of clopamide 5 mg as monotherapy for 16 weeks [9].

Associations of clopamide with other chemical compounds

• Two fixed combinations of beta-blockers and diuretics, penbutolol plus furosemide and pindolol plus clopamide, were compared with respect to efficacy, safety, and tolerability in hypertensive out-patients [10].
• 1.0 mM furosemide, 0.1 mM spironolactone, 0.01 mM clopamide and 0.8 mM acetazolamide did not change the reaction to ADH [11].
• The reserpine/ clopamide and enalapril groups did not differ with regard to demographic and baseline characteristics (mean age 57 or 58 years, respectively; 63% or 56% males, respectively; mean SBP/DBP after the 2-week placebo period = 156 mmHg/104 mmHg in both groups) [1].

Analytical, diagnostic and therapeutic context of clopamide

• 1 We have assessed the efficacy of Viskaldix, a combination of pindolol 10 mg and clopamide 5 mg using continuous intra-arterial ambulatory blood pressure monitoring [12].

References