Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

PubChem19741 3-hydroxy-4-methoxy-benzoic acid

Synonyms: CHEMBL88700, SureCN180473, AG-G-42119, CHEBI:63798, ANW-34896, ...

Malarczyk, E. et al., Tang, Z. et al., Jeffers, M.R. et al., Tuomainen, P. et al.

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Disease relevance of BRN 2208365

Vanillic acid at 0.2% concentration in the medium of Nocardia autotrophic DSM 43100 leads to cyclic production of guaiacol; protocatechuic and p-hydroxybenzoic acids as well as catechol appear at the same time in the medium instead of isovanillic acid, which accumulates at lower vanillic acid concentration [1].

High impact information on BRN 2208365

A methyltransferase enzyme catalysing the 3-O-methylation of isovanillic acid (3-hydroxy-4-methoxybenzoic acid) by S-adenosylmethionine (SAM) was identified in Phanerochaete chrysosporium and purified [2].
A method based on capillary electrophoresis with electrochemical detection has been developed for the separation and determination of isovanillic acid, gentisic acid, kaempferol, quercetin, caffeic acid and protocatechuic acid in Ilex Purpurea Hassk and its medicinal preparations for the first time [3].
The reaction products (vanillic acid and isovanillic acid) were analyzable by HPLC with electrochemical detection directly in the incubation medium after protein precipitation [4].

References

New aspects of co-regulation of decarboxylation and demethylation activities in Nocardia. Malarczyk, E., Kochmańska-Rdest, J. Acta Biochim. Pol. (1990) [Pubmed]
Identification of a phenolic 3-O-methyltransferase in the lignin-degrading fungus Phanerochaete chrysosporium. Jeffers, M.R., McRoberts, W.C., Harper, D.B. Microbiology (Reading, Engl.) (1997) [Pubmed]
Determination of active ingredients of Ilex Purpurea Hassk and its medicinal preparations by capillary electrophoresis with electrochemical detection. Tang, Z., Zhou, Y., Zeng, Y., Zang, S., He, P., Fang, Y. Journal of pharmaceutical and biomedical analysis. (2006) [Pubmed]
Validation of assay of catechol-O-methyltransferase activity in human erythrocytes. Tuomainen, P., Reenilä, I., Männistö, P.T. Journal of pharmaceutical and biomedical analysis. (1996) [Pubmed]

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