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Chemical Compound Review

SureCN30289     2-methylbenzene-1,3-diamine

Synonyms: CCRIS 3031, NCI-C50317, AG-H-29692, ACMC-209pob, CHEBI:76288, ...
 
 
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Disease relevance of Toluenediamine

 

High impact information on Toluenediamine

 

Biological context of Toluenediamine

  • Analysis of urine samples from rats administered TDA (p.o., i.v.) and TDI (p.o., inhalation) indicated that all of the metabolic Ac-TDA from these test materials was the 4-acetyl-TDA isomer [6].
  • Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate [7].
  • The same happened with 2,6-toluenediamine, with the exception of a significant increase over controls in the amounts of DNA damage and repair displayed by hepatocyte cultures obtained from rats given two 1/2 LD50 separated by a 24 h interval [8].
 

Associations of Toluenediamine with other chemical compounds

 

Analytical, diagnostic and therapeutic context of Toluenediamine

References

  1. Correlation of hepatocellular proliferation with hepatocarcinogenicity induced by the mutagenic noncarcinogen:carcinogen pair--2,6- and 2,4-diaminotoluene. Cunningham, M.L., Foley, J., Maronpot, R.R., Matthews, H.B. Toxicol. Appl. Pharmacol. (1991) [Pubmed]
  2. Biomarkers in hydrolysed urine, plasma and erythrocytes among workers exposed to thermal degradation products from toluene diisocyanate foam. Lind, P., Dalene, M., Tinnerberg, H., Skarping, G. The Analyst. (1997) [Pubmed]
  3. Interaction with the aromatic hydrocarbon receptor, CYP1A induction, and mutagenicity of a series of diaminotoluenes: implications for their carcinogenicity. Cheung, Y.L., Snelling, J., Mohammed, N.N., Gray, T.J., Ioannides, C. Toxicol. Appl. Pharmacol. (1996) [Pubmed]
  4. Spectral dependence of UV-induced immediate and delayed apoptosis: the role of membrane and DNA damage. Godar, D.E., Lucas, A.D. Photochem. Photobiol. (1995) [Pubmed]
  5. Analysis of the extractive and hydrolytic behavior of microthane poly(ester-urethane) foam by high pressure liquid chromatography. Amin, P., Wille, J., Shah, K., Kydonieus, A. J. Biomed. Mater. Res. (1993) [Pubmed]
  6. Gas chromatographic/tandem mass spectrometric identification and quantitation of metabolic 4-acetyltoluene-2,4-diamine from the F344 rat. Bartels, M.J., Timchalk, C., Smith, F.A. Biol. Mass Spectrom. (1993) [Pubmed]
  7. Biological monitoring of isocyanates and related amines. IV. 2,4- and 2,6-toluenediamine in hydrolysed plasma and urine after test-chamber exposure of humans to 2,4- and 2,6-toluene diisocyanate. Brorson, T., Skarping, G., Sangö, C. International archives of occupational and environmental health. (1991) [Pubmed]
  8. Evaluation in a battery of in vivo assays of four in vitro genotoxins proved to be noncarcinogens in rodents. Allavena, A., Martelli, A., Robbiano, L., Brambilla, G. Teratog., Carcinog. Mutagen. (1992) [Pubmed]
  9. Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA). Kääriä, K., Hirvonen, A., Norppa, H., Piirilä, P., Vainio, H., Rosenberg, C. The Analyst. (2001) [Pubmed]
  10. Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate. Skarping, G., Brorson, T., Sangö, C. International archives of occupational and environmental health. (1991) [Pubmed]
 
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