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Chemical Compound Review

Diisocyanatotoluene     1,3-diisocyanato-2-methyl- benzene

Synonyms: hylene-t, mondur-td, mondur-td-80, Nacconate-100, Rubinate TDI, ...
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Disease relevance of TOLUENE DIISOCYANATE


High impact information on TOLUENE DIISOCYANATE


Biological context of TOLUENE DIISOCYANATE


Anatomical context of TOLUENE DIISOCYANATE



  • These investigations showed that the most commonly used isocyanates, toluene diisocyanate (TDI) and 4,4'-methylene-diphenylisocyanate (MDI), are mutagenic [6].
  • TDI (10(-4)-10(-5) mol/L, as a mixture of 80% 2,4-TDI and 20% 2,6-TDI) exhibited a partial but significant cytotoxic effect (10-24%, p<0.05) on HLFs [10].

Analytical, diagnostic and therapeutic context of TOLUENE DIISOCYANATE

  • To investigate the process of toluene diisocyanate (TDI) sensitization, studies were conducted to identify TDI-protein adducts in the bronchoalveolar lavage (BAL) fluid of guinea pigs exposed to a sensitizing atmosphere of the commercially used 4:1 mixture of 2,4- and 2,6-TDI [11].


  1. Long-term toxicity and carcinogenicity studies with 2,4/2,6-toluene-diisocyanate (80/20) in rats and mice. Loeser, E. Toxicol. Lett. (1983) [Pubmed]
  2. In vivo and in vitro reactions of toluene diisocyanate isomers with guinea pig hemoglobin. Day, B.W., Jin, R., Karol, M.H. Chem. Res. Toxicol. (1996) [Pubmed]
  3. Exposure to 2,4- and 2,6-toluene diisocyanate (TDI) during production of flexible foam: determination of airborne TDI and urinary 2,4- and 2,6-toluenediamine (TDA). Kääriä, K., Hirvonen, A., Norppa, H., Piirilä, P., Vainio, H., Rosenberg, C. The Analyst. (2001) [Pubmed]
  4. Albumin adducts in plasma from workers exposed to toluene diisocyanate. Lind, P., Dalene, M., Lindström, V., Grubb, A., Skarping, G. The Analyst. (1997) [Pubmed]
  5. Cytokine mRNA profiles for isocyanates with known and unknown potential to induce respiratory sensitization. Plitnick, L.M., Loveless, S.E., Ladics, G.S., Holsapple, M.P., Smialowicz, R.J., Woolhiser, M.R., Anderson, P.K., Smith, C., Selgrade, M.J. Toxicology (2005) [Pubmed]
  6. Mutagenic action of isocyanates used in the production of polyurethanes. Andersen, M., Binderup, M.L., Kiel, P., Larsen, H., Maxild, J. Scandinavian journal of work, environment & health. (1980) [Pubmed]
  7. Biological monitoring of isocyanates and related amines. III. Test chamber exposure of humans to toluene diisocyanate. Skarping, G., Brorson, T., Sangö, C. International archives of occupational and environmental health. (1991) [Pubmed]
  8. Workers exposed to thermal degradation products of TDI- and MDI-based polyurethane: biomonitoring of 2,4-TDA, 2,6-TDA, and 4,4'-MDA in hydrolyzed urine and plasma. Dalene, M., Skarping, G., Lind, P. American Industrial Hygiene Association journal. (1997) [Pubmed]
  9. Histamine content and histamine H1 receptor in experimentally-induced nasal hypersensitivity. Kubo, N., Hori, Y., Tomoda, K., Yamashita, T., Kumazawa, T. Acta oto-laryngologica. Supplementum. (1989) [Pubmed]
  10. Effect of toluene diisocyanate and its corresponding amines on viability and growth of human lung fibroblasts in culture. Pons, F., Fischer, A., Frossard, N., Lugnier, A. Cell Biol. Toxicol. (1999) [Pubmed]
  11. Toluene diisocyanate protein adducts in the bronchoalveolar lavage of guinea pigs exposed to vapors of the chemical. Jin, R., Day, B.W., Karol, M.H. Chem. Res. Toxicol. (1993) [Pubmed]
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