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MeSH Review

Breast Implants

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Disease relevance of Breast Implants


High impact information on Breast Implants

  • Are they real? IOM report on breast implant problems. Institute of Medicine [6].
  • In contrast, only one (0.3%) of 286 new patients with rheumatoid arthritis who were seen during the same interval had had a breast implant [7].
  • PARTICIPANTS: 307 of the 875 women in the Postmenopausal Estrogen/Progestin Interventions Trial. Participants had a baseline mammogram and at least one follow-up mammogram available, adhered to treatment, had not taken estrogen for at least 5 years before baseline, and did not have breast implants [8].
  • Human immune response to polydimethylsiloxane (silicone): screening studies in a breast implant population [9].
  • Among women with silicone breast implants, 13 subsequently developed a neurologic disorder compared with 7.7 expected; whereas in the comparison group, 63 observed versus 39.1 expected disorders were recorded [10].

Chemical compound and disease context of Breast Implants


Biological context of Breast Implants


Anatomical context of Breast Implants


Associations of Breast Implants with chemical compounds


Gene context of Breast Implants


Analytical, diagnostic and therapeutic context of Breast Implants


  1. Cancer incidence in a cohort of Ontario and Quebec women having bilateral breast augmentation. Brisson, J., Holowaty, E.J., Villeneuve, P.J., Xie, L., Ugnat, A.M., Latulippe, L., Mao, Y. Int. J. Cancer (2006) [Pubmed]
  2. Development of polyarthritis after insertion of silicone breast implants followed by remission after implant removal in 2 HLA-identical sisters bearing rheumatoid arthritis susceptibility genes. Meier, L.G., Barthel, H.R., Seidl, C. J. Rheumatol. (1997) [Pubmed]
  3. Silicone filled breast implants and the risk of fibromyalgia and rheumatoid arthritis. Wolfe, F., Anderson, J. J. Rheumatol. (1999) [Pubmed]
  4. Anti-collagen autoantibodies are found in women with silicone breast implants. Teuber, S.S., Rowley, M.J., Yoshida, S.H., Ansari, A.A., Gershwin, M.E. J. Autoimmun. (1993) [Pubmed]
  5. The effect of Siltex texturing and povidone-iodine irrigation on capsular contracture around saline inflatable breast implants. Burkhardt, B.R., Demas, C.P. Plast. Reconstr. Surg. (1994) [Pubmed]
  6. Are they real? IOM report on breast implant problems. Institute of Medicine. Marwick, C. JAMA (1999) [Pubmed]
  7. Scleroderma after silicone augmentation mammoplasty. Spiera, H. JAMA (1988) [Pubmed]
  8. Effects of estrogen and estrogen-progestin on mammographic parenchymal density. Postmenopausal Estrogen/Progestin Interventions (PEPI) Investigators. Greendale, G.A., Reboussin, B.A., Sie, A., Singh, H.R., Olson, L.K., Gatewood, O., Bassett, L.W., Wasilauskas, C., Bush, T., Barrett-Connor, E. Ann. Intern. Med. (1999) [Pubmed]
  9. Human immune response to polydimethylsiloxane (silicone): screening studies in a breast implant population. Wolf, L.E., Lappé, M., Peterson, R.D., Ezrailson, E.G. FASEB J. (1993) [Pubmed]
  10. Neurologic disease among women with breast implants. Winther, J.F., Bach, F.W., Friis, S., Blot, W.J., Mellemkjaer, L., Kjøller, K., Høgsted, C., McLaughlin, J.K., Olsen, J.H. Neurology (1998) [Pubmed]
  11. Granulomatous reaction to silicone in axillary lymph nodes. A case report with cytologic findings. Santos-Briz, A., López-Ríos, F., Santos-Briz, A., De Agustín, P.P. Acta Cytol. (1999) [Pubmed]
  12. The many faces of scleroderma. Smiley, J.D. Am. J. Med. Sci. (1992) [Pubmed]
  13. Localized Mycobacterium avium-intracellulare mastitis in an immunocompetent woman with silicone breast implants. Lee, D., Goldstein, E.J., Zarem, H.A. Plast. Reconstr. Surg. (1995) [Pubmed]
  14. Vitamin E and capsule contracture. Caffee, H.H. Annals of plastic surgery. (1987) [Pubmed]
  15. Systemic sclerosis: environmental and occupational risk factors. Nietert, P.J., Silver, R.M. Current opinion in rheumatology. (2000) [Pubmed]
  16. A physiologically based pharmacokinetic model for 2,4-toluenediamine leached from polyurethane foam-covered breast implants. Luu, H.M., Hutter, J.C., Bushar, H.F. Environ. Health Perspect. (1998) [Pubmed]
  17. Silicone gel and octamethylcyclotetrasiloxane (D4) enhances antibody production to bovine serum albumin in mice. Nicholson, J.J., Hill, S.L., Frondoza, C.G., Rose, N.R. J. Biomed. Mater. Res. (1996) [Pubmed]
  18. Measurement of 2,4-toluenediamine in urine and serum samples from women with Même or Replicon breast implants. Hester, T.R., Ford, N.F., Gale, P.J., Hammett, J.L., Raymond, R., Turnbull, D., Frankos, V.H., Cohen, M.B. Plast. Reconstr. Surg. (1997) [Pubmed]
  19. Systemic inflammatory diseases and silicone breast prostheses: report of a case of adult still disease and review of the literature. Montalto, M., Vastola, M., Santoro, L., La Regina, M., Curigliano, V., Manna, R., Gasbarrini, G. Am. J. Med. Sci. (2004) [Pubmed]
  20. The silicone breast implant controversy. Silicone toxicity and autoimmunity. Brautbar, N. National medical-legal journal. (1995) [Pubmed]
  21. Total Platinum Concentration and Platinum Oxidation States in Body Fluids, Tissue, and Explants from Women Exposed to Silicone and Saline Breast Implants by IC-ICPMS. Lykissa, E.D., Maharaj, S.V. Anal. Chem. (2006) [Pubmed]
  22. Breast implants, rheumatoid arthritis, and connective tissue diseases in a clinical practice. Goldman, J.A., Greenblatt, J., Joines, R., White, L., Aylward, B., Lamm, S.H. Journal of clinical epidemiology. (1995) [Pubmed]
  23. Breast reconstruction with a subcutaneous tissue expander followed with a polyurethane-covered silicone breast implant. Artz, J.S., Dinner, M.I., Sampliner, J. Annals of plastic surgery. (1988) [Pubmed]
  24. Breast implants redux: this time with data. Ferguson, J.H. Neurology (1998) [Pubmed]
  25. Urinary excretion of free toluenediamines in a patient with polyurethane-covered breast implants. Chan, S.C., Birdsell, D.C., Gradeen, C.Y. Clin. Chem. (1991) [Pubmed]
  26. Silicone gel-filled breast implants in women: findings at H-1 MR spectroscopy. Pfleiderer, B., Campbell, T., Hulka, C.A., Kopans, D.B., Lean, C.L., Ackerman, J.L., Brady, T.J., Garrido, L. Radiology. (1996) [Pubmed]
  27. Chemical shift imaging with spectrum modeling. An, L., Xiang, Q.S. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. (2001) [Pubmed]
  28. Elevated concentrations of interleukin-1 beta and interleukin-1 receptor antagonist in plasma of women with silicone breast implants. Ojo-Amaize, E.A., Lawless, O.J., Peter, J.B. Clin. Diagn. Lab. Immunol. (1996) [Pubmed]
  29. Local increase in hyaluronic acid and interleukin-2 in the capsules surrounding silicone breast implants. Wells, A.F., Daniels, S., Gunasekaran, S., Wells, K.E. Annals of plastic surgery. (1994) [Pubmed]
  30. Lack of evidence of systemic inflammatory rheumatic disorders in symptomatic women with breast implants. Blackburn, W.D., Grotting, J.C., Everson, M.P. Plast. Reconstr. Surg. (1997) [Pubmed]
  31. Role of connective tissue growth factor in breast implant elastomer capsular formation. Mazaheri, M.K., Schultz, G.S., Blalock, T.D., Caffee, H.H., Chin, G.A. Annals of plastic surgery. (2003) [Pubmed]
  32. Novel anti-silicone surface-associated antigen antibodies (anti-SSAA(x)) may help differentiate symptomatic patients with silicone breast implants from patients with classical rheumatological disease. Kossovsky, N., Conway, D., Kossowsky, R., Petrovich, D. Curr. Top. Microbiol. Immunol. (1996) [Pubmed]
  33. Comparative epitope mapping of antibodies to collagen in women with silicone breast implants, systemic lupus erythematosus and rheumatoid arthritis. Rowley, M.J., Cook, A.D., Mackay, I.R., Teuber, S.S., Gershwin, M.E. Curr. Top. Microbiol. Immunol. (1996) [Pubmed]
  34. A review of the possible health implications of silicone breast implants. Noone, R.B. Cancer (1997) [Pubmed]
  35. Comparative experience with smooth and polyurethane breast implants using the Kaplan-Meier method of survival analysis. Handel, N., Silverstein, M.J., Jensen, J.A., Collins, A., Zierk, K. Plast. Reconstr. Surg. (1991) [Pubmed]
  36. Breast implants, common complications, and concurrent breast disease. Steinbach, B.G., Hardt, N.S., Abbitt, P.L., Lanier, L., Caffee, H.H. Radiographics : a review publication of the Radiological Society of North America, Inc. (1993) [Pubmed]
  37. Comparison of resource costs between implant-based and TRAM flap breast reconstruction. Kroll, S.S., Evans, G.R., Reece, G.P., Miller, M.J., Robb, G., Baldwin, B.J., Schusterman, M.A. Plast. Reconstr. Surg. (1996) [Pubmed]
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