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Chemical Compound Review

Bioquin     quinolin-8-ol

Synonyms: Fennosan, Oxine, Oxychinolin, Quinophenol, Oxyquinoline, ...
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Disease relevance of Bioquin


Psychiatry related information on Bioquin


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Chemical compound and disease context of Bioquin


Biological context of Bioquin


Anatomical context of Bioquin


Associations of Bioquin with other chemical compounds


Gene context of Bioquin


Analytical, diagnostic and therapeutic context of Bioquin

  • While this latter finding could be used as an objective means of assessing response to therapy, it is concluded that conventional indium scintigraphy, using indium oxine-labelling of mixed leucocytes, is insufficiently reliable to replace usual methods for determining extent of disease in patients with inflammatory bowel disease [34].
  • The high energy gamma emission of 111Indium oxine allows for external scanning using a standard gamma camera [35].
  • In situ raman spectroscopy studies of metal ion complexation by 8-hydroxyquinoline covalently bound to silica surfaces [36].
  • The studies revealed that excess of oxine (50 microgram oxine/1.6 x 10(9) platelets in 1 ml MTS), and centrifugation at greater than 1000 g, reduced platelet aggregability [37].
  • 111In oxine labeled red cells for detection of simulated lower gastrointestinal bleeding in an animal model [38].


  1. Unsuspected osteomyelitis in diabetic foot ulcers. Diagnosis and monitoring by leukocyte scanning with indium in 111 oxyquinoline. Newman, L.G., Waller, J., Palestro, C.J., Schwartz, M., Klein, M.J., Hermann, G., Harrington, E., Harrington, M., Roman, S.H., Stagnaro-Green, A. JAMA (1991) [Pubmed]
  2. Oxyquinoline toxicity. Soffer, M., Basdevant, A., Sarragoussi, J.J., Raison, J., Guy-Grand, B. Lancet (1983) [Pubmed]
  3. Scintigraphic assessment of bowel involvement and disease activity in Crohn's disease using technetium 99m-hexamethyl propylene amine oxine as leukocyte label. Schölmerich, J., Schmidt, E., Schümichen, C., Billmann, P., Schmidt, H., Gerok, W. Gastroenterology (1988) [Pubmed]
  4. Imaging the inflammatory response to acute myocardial infarction in man using indium-111-labeled autologous platelets. Davies, R.A., Thakur, M.L., Berger, H.J., Wackers, F.J., Gottschalk, A., Zaret, B.L. Circulation (1981) [Pubmed]
  5. Increased blood clearance rate of indium-111 oxine-labeled autologous CD4+ blood cells in untreated patients with Hodgkin's disease. Grimfors, G., Holm, G., Mellstedt, H., Schnell, P.O., Tullgren, O., Björkholm, M. Blood (1990) [Pubmed]
  6. Clioquinol, a drug for Alzheimer's disease specifically interfering with brain metal metabolism: structural characterization of its zinc(II) and copper(II) complexes. Di Vaira, M., Bazzicalupi, C., Orioli, P., Messori, L., Bruni, B., Zatta, P. Inorganic chemistry. (2004) [Pubmed]
  7. Comparison study of five analytical methods for the fractionation and subsequent determination of aluminium in natural water samples. Wickstrøm, T., Clarke, N., Derome, K., Derome, J., Røgeberg, E. Journal of environmental monitoring : JEM. (2000) [Pubmed]
  8. Cytopathogenic mechanisms of Entamoeba histolytica. Ravdin, J.I., Croft, B.Y., Guerrant, R.L. J. Exp. Med. (1980) [Pubmed]
  9. Enhancement of rat hepatocellular-altered foci by the liver tumor promoter phenobarbital: evidence that foci are precursors of neoplasms and that the promoter acts on carcinogen-induced lesions. Watanabe, K., Williams, G.M. J. Natl. Cancer Inst. (1978) [Pubmed]
  10. Arabidopsis thaliana gamma-glutamylcysteine synthetase is structurally unrelated to mammalian, yeast, and Escherichia coli homologs. May, M.J., Leaver, C.J. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  11. Migration of human dendritic cells after injection in patients with metastatic malignancies. Morse, M.A., Coleman, R.E., Akabani, G., Niehaus, N., Coleman, D., Lyerly, H.K. Cancer Res. (1999) [Pubmed]
  12. Effect of clioquinol, an 8-hydroxyquinoline derivative, on rotavirus infection in mice. Bednarz-Prashad, A.J., John, E.I. J. Infect. Dis. (1983) [Pubmed]
  13. The mechanism of inhibition of ribonucleic acid synthesis by 8-hydroxyquinoline and the antibiotic lomofungin. Fraser, R.S., Creanor, J. Biochem. J. (1975) [Pubmed]
  14. Technetium-99m hexamethyl propylene amine oxine leucocytes in the assessment of disease activity in inflammatory bowel disease. Lantto, E., Järvi, K., Krekelä, I., Lantto, T., Taavitsainen, M., Vedenkangas, H., Vorne, M. European journal of nuclear medicine. (1992) [Pubmed]
  15. Selective removal of molybdenum traces from growth media of N2-fixing bacteria. Schneider, K., Müller, A., Johannes, K.U., Diemann, E., Kottmann, J. Anal. Biochem. (1991) [Pubmed]
  16. Reversal of fungitoxicity of 8-quinolinols and their copper(II) bischelates. II. Reversal of the action of 8-quinolinol by DL-alpha-lipoic acid. Gershon, H., Shanks, L. Can. J. Microbiol. (1981) [Pubmed]
  17. Effects of systematic methyl substitution of metal (III) tris(n-methyl-8-quinolinolato) chelates on material properties for optimum electroluminescence device performance. Sapochak, L.S., Padmaperuma, A., Washton, N., Endrino, F., Schmett, G.T., Marshall, J., Fogarty, D., Burrows, P.E., Forrest, S.R. J. Am. Chem. Soc. (2001) [Pubmed]
  18. Cell proliferation in Allium cepa L. meristems under 8-hydroxyquinoline, a chelating agent that affects DNA and RNA polymerases. Ferrero, M.L., De la Torre, C. J. Cell. Sci. (1986) [Pubmed]
  19. Antimalarial activity of selected aromatic chelators. IV. Cation uptake by Plasmodium falciparum in the presence of oxines and siderochromes. Scheibel, L.W., Stanton, G.G. Mol. Pharmacol. (1986) [Pubmed]
  20. Concentration jump experiments for the precise determination of rate constants of reverse reactions in the millisecond time range. Buet, P., Lewitzki, E., Grell, E., Albrecht-Gary, A.M., Wannowius, K.J., Mass, F., Elias, H., Mundt, A.A., Dupont, Y. Anal. Chem. (2001) [Pubmed]
  21. Indium-111-labeled human polymorphonuclear leukocytes: viability, random migration, chemotaxis, bacterial capacity, and ultrastructure. Zakhireh, B., Thakur, M.L., Malech, H.L., Cohen, M.S., Gottschalk, A., Root, R.K. J. Nucl. Med. (1979) [Pubmed]
  22. Metabolism of N-hydroxy-2-acetylaminofluorene and N-hydroxy-2-aminofluorene by guinea pig liver microsomes. Razzouk, C., Batardy-Grégoire, M., Roberfroid, M. Cancer Res. (1982) [Pubmed]
  23. Human monocyte-mediated tumor cytotoxicity. I. Demonstration of an oxygen-dependent myeloperoxidase-independent mechanism. Mavier, P., Edgington, T.S. J. Immunol. (1984) [Pubmed]
  24. Cell damage resulting from the labeling of rat lymphocytes and HeLa S3 cells with In-111 oxine. Chisholm, P.M., Danpure, H.J., Healey, G., Osman, S. J. Nucl. Med. (1979) [Pubmed]
  25. Neutrophil labeling with indium-111: tropolone vs. oxine. Gunter, K.P., Lukens, J.N., Clanton, J.A., Morris, P.J., Janco, R.L., English, D. Radiology. (1983) [Pubmed]
  26. Diagnosis of arterial prosthetic graft infection by indium-111 oxine white blood cell scans. McKeown, P.P., Miller, D.C., Jamieson, S.W., Mitchell, R.S., Reitz, B.A., Olcott, C., Mehigan, J.T., Silberstein, R.J., McDougall, I.R. Circulation (1982) [Pubmed]
  27. Manganese(II) and Manganese(III) 8-quinolinol complexes. Redox model for mitochondrial superoxide dismutase. Howie, J.K., Sawyer, D.T. J. Am. Chem. Soc. (1976) [Pubmed]
  28. The molecular structure of indium oxine. Green, M.A., Huffman, J.C. J. Nucl. Med. (1988) [Pubmed]
  29. 8-Hydroxyquinoline inhibits iNOS expression and nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and C/EBPbeta in Raw 264.7 cells. Kim, Y.H., Woo, K.J., Lim, J.H., Kim, S., Lee, T.J., Jung, E.M., Lee, J.M., Park, J.W., Kwon, T.K. Biochem. Biophys. Res. Commun. (2005) [Pubmed]
  30. Concentration of metabolites and the regulation of phosphofructokinase and fructose-1,6-bisphosphatase in Saccharomyces cerevisiae. Foy, J.J., Bhattacharjee, J.K. Arch. Microbiol. (1981) [Pubmed]
  31. Evaluation of the genotoxic activity of metronidazole and dimetridazole in human lymphocytes by the comet assay. Ré, J.L., De Méo, M.P., Laget, M., Guiraud, H., Castegnaro, M., Vanelle, P., Duménil, G. Mutat. Res. (1997) [Pubmed]
  32. An assay for estimating the cytotoxicity of synovial fluid from patients with rheumatoid arthritis. Blann, A.D. Scand. J. Clin. Lab. Invest. (1985) [Pubmed]
  33. Prooxidant action of xanthurenic acid and quinoline compounds: role of transition metals in the generation of reactive oxygen species and enhanced formation of 8-hydroxy-2'-deoxyguanosine in DNA. Murakami, K., Haneda, M., Yoshino, M. Biometals (2006) [Pubmed]
  34. Evaluation of indium scintigraphy in patients with active inflammatory bowel disease. Buxton-Thomas, M.S., Dickinson, R.J., Maltby, P., Hunter, J.O., Wraight, E.P. Gut (1984) [Pubmed]
  35. A primate model for the study of the interaction of 111In-labeled baboon platelets with Dacron arterial prostheses. Callow, A.D., Ledig, C.B., O'Donnell, T.F., Kelly, J.J., Rosenthal, D., Korwin, S., Hotte, C., Kahn, P.C., Vecchione, J.J., Valeri, C.R. Ann. Surg. (1980) [Pubmed]
  36. In situ raman spectroscopy studies of metal ion complexation by 8-hydroxyquinoline covalently bound to silica surfaces. Uibel, R.H., Harris, J.M. Anal. Chem. (2002) [Pubmed]
  37. Indium-111-labeled human platelets: improved method, efficacy, and evaluation. Thakur, M.L., Walsh, L., Malech, H.L., Gottschalk, A. J. Nucl. Med. (1981) [Pubmed]
  38. 111In oxine labeled red cells for detection of simulated lower gastrointestinal bleeding in an animal model. Winzelberg, G.G., Castronovo, F.P., Callahan, R.J., McKusick, K.A., Strauss, H.W. Radiology. (1980) [Pubmed]
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