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Chemical Compound Review

ATEE     ethyl (2S)-2-acetamido-3-(4...

Synonyms: Ac-Tyr-OEt, Ac-Tyr-OEt?H2O, PubChem13178, TYR001, SureCN468756, ...
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Disease relevance of Ethyl acetyltyrosinate


High impact information on Ethyl acetyltyrosinate

  • The irreversible proteinase inhibitor 3,4-dichloroisocoumarin (DCI) also blocked both chromium release and DNA fragmentation, but at significantly lower concentrations than ATEE [2].
  • Both (2R,3S)- and (2S,3R)- delta EPhe-Phe(or Leu)-OMe were found to inhibit effectively the hydrolysis of Ac-Tyr-OEt by chymotrypsin in a competitive manner [3].
  • But, in contrast to qBBr or methylation inhibitors, neither TEE nor ATEE was more effective when added prior to the initial effector-target interaction [4].
  • Ac-Tyr-OEt, on the other hand, caused a marked accumulation of Ag-Ab complex in the lysosome fraction, reflecting the inhibition of intralysosomal digestion of the complex.(ABSTRACT TRUNCATED AT 250 WORDS)[5]
  • When phagocytosis of the Ag-Ab complex was assayed by measuring the amount of digested products released from macrophage cells, Ac-Tyr-OEt also inhibited it as markedly as Ac-Phe-OEt, Ac-Trp-OEt, and Bz-Tyr-OEt did, whereas Bz-Arg-OEt again did not show any effect [5].

Biological context of Ethyl acetyltyrosinate


Associations of Ethyl acetyltyrosinate with other chemical compounds


Gene context of Ethyl acetyltyrosinate


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  2. Proteinases are involved in both DNA fragmentation and membrane damage during CTL-mediated target cell killing. Helgason, C.D., Atkinson, E.A., Pinkoski, M.J., Bleackley, R.C. Exp. Cell Res. (1995) [Pubmed]
  3. Enzyme inhibition by dipeptides containing 2,3-methanophenylalanine, a sterically constrained amino acid. Ogawa, T., Yoshitomi, H., Kodama, H., Waki, M., Stammer, C.H., Shimohigashi, Y. FEBS Lett. (1989) [Pubmed]
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  10. Chemistry in a microenvironment of low pH, generated with the aid of an immobilized proteinase. Silver, M.S., Haskell, J.H. Biochim. Biophys. Acta (1990) [Pubmed]
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