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Chemical Compound Review

CTK1D6131     2-ethenylbenzaldehyde

Synonyms: AKOS006276175, AC1L21N7, 28272-96-0, ETHENYLBENZALDEHYDE, 2-vinyl-benzaldehyde, ...
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Disease relevance of DIC


High impact information on DIC


Chemical compound and disease context of DIC


Biological context of DIC

  • When extracellular Ca2+ was chelated by ethylene glycol-bis(beta-aminoethyl ether)-N,N,-tetraacetic acid (EGTA) during coincubation or when the pit cells were preincubated with the granzyme inhibitor 3,4-dichloroisocoumarin (DCI), the induction of apoptosis was abolished [15].
  • 3,4-Dichloroisocoumarin, by reacting with the chymotrypsin-like, trypsin-like, and/or PGP-active sites, may promote a conformational change of MPC, rendering the caseinolytic active site accessible to the substrate [16].
  • 3,4-Dichloroisocoumarin, the most effective compound, rapidly induces HSF1 DNA binding activity and phosphorylation, leading to transcription and translation of heat shock genes for a period of several hours [2].
  • Immunologic cross-reactivity between two DIC-treated leukemic sublines has been demonstrated by cell-mediated immunity in vitro and by active or adoptive immunity in vivo [17].
  • The Tctex-1 binding site on DIC was mapped to a 19-residue fragment immediately following the second alternative splicing site of DIC [18].

Anatomical context of DIC

  • Anti-L5178Y/DIC lymphocytes did not cure mice challenged with the parent L5178Y tumor [8].
  • We have used video-enhanced DIC microscopy to examine the effects of XMAP, a Mr 215,000 microtubule-associated protein from Xenopus eggs (Gard, D.L., and M. W. Kirschner. 1987. J. Cell Biol. 105:2203-2215), on the dynamic instability of microtubules nucleated from axoneme fragments in vitro [19].
  • Simultaneous IRM and DIC imaging showed that cytoplasm invaded filopodia when only their tips were closely apposed to a substrate but not when they were closely apposed to a substrate along their entire lengths [20].
  • In the other experiments, the ultraviolet output of a pulsed neodymium-YAG laser was focused to a microbeam through a quartz objective lens in epi-illumination mode and used to selectively kill individual unlabeled hair cells while the cells were simultaneously imaged by transmitted light DIC microscopy [21].
  • For liver microsomes, the rate of reaction for BIC is greater than that for DIC, but apparently neither rate is fast enough to allow extensive metabolism of large doses of these agents [22].

Associations of DIC with other chemical compounds

  • In addition, ERAD is limited in vitro in the presence of the proteasome inhibitors, 3,4-dichloroisocoumarin and lactacystin [23].
  • The stimulation of annexin binding following osmotic shock is mimicked by addition of ceramide or purified sphingomyelinase and significantly blunted by genetic (aSM-deficient mice) or pharmacologic (50 microM 3,4-dichloroisocoumarin) knockout of sphingomyelinase [24].
  • Likewise, the serine protease inhibitors, N-tosyl-L-phenyl chloromethyl ketone (TPCK) and 3,4-dichloroisocoumarin (DCI), prevented apoptosis, whereas N-tosyl-L-lysine chloromethyl ketone (TLCK), Ac-Leu-Leu-L-norleucinal, Ac-Leu-Leu-L-methional, and trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane were without effect [25].
  • The antitumor agents 5-(3,3-dimethyl-1-triazenyl)imidazole-4-carboxamide (DIC) and 5-[3,3-bis(2-chloroethyl)-1-triazenyl]imidazole-4-carboxamide (BIC) are substrates for NADPH-requiring microsomal enzymes of mouse liver [22].
  • Cbz-GPFL-CHO inhibited the BrAAP activity with the same Ki both before and after activation of this component by exposure of the MPC to 3,4-dichloroisocoumarin, suggesting that the peptidyl aldehyde is an effective inhibitor of both the overt and latent proteolytic activities of the MPC [26].

Gene context of DIC

  • We further demonstrated that Tctex-1 binds directly to the intermediate chain (DIC) of dynein [18].
  • Activation of tissue factor-dependent coagulation pathway not adequately balanced by TFPI has important roles in sustaining DIC and systemic inflammatory response syndrome, and it contributes to multiple organ dysfunction syndrome and death [27].
  • These results suggest that interleukin-1 and TNF-alpha may play a pivotal role in the pathogenesis of DIC [28].
  • Sf9 cells were infected with recombinant baculovirus expressing the cDNA of LSP1 truncates and mutants, and the morphology of infected Sf9 cells was documented by DIC optics [29].
  • Generation and characterization of a murine model of a total PC gene inactivation has demonstrated that while an untreated total PC deficiency results in neonatal death through DIC-related abnormalities, a valuable resource is now available to study phenotypes of less severe deficiencies of this protein [30].

Analytical, diagnostic and therapeutic context of DIC


  1. Increased immunogenicity of two lymphoma lines after drug treatment of athymic (nude) mice. Campanile, F., Houchens, D.P., Gaston, M., Goldin, A., Bonmassar, E. J. Natl. Cancer Inst. (1975) [Pubmed]
  2. Activation of the heat shock factor 1 by serine protease inhibitors. An effect associated with nuclear factor-kappaB inhibition. Rossi, A., Elia, G., Santoro, M.G. J. Biol. Chem. (1998) [Pubmed]
  3. Hemostasis in massively transfused trauma patients. Counts, R.B., Haisch, C., Simon, T.L., Maxwell, N.G., Heimbach, D.M., Carrico, C.J. Ann. Surg. (1979) [Pubmed]
  4. Bacterial arthritis due to beta-hemolytic streptococci of serogroups A, B, C, F, and G. Analysis of 23 cases and a review of the literature. Schattner, A., Vosti, K.L. Medicine (Baltimore) (1998) [Pubmed]
  5. Influenza C virus esterase: analysis of catalytic site, inhibition, and possible function. Vlasak, R., Muster, T., Lauro, A.M., Powers, J.C., Palese, P. J. Virol. (1989) [Pubmed]
  6. Letter: ICF instead of DIC? Hardaway, R.M. N. Engl. J. Med. (1975) [Pubmed]
  7. A natural killer cell granule protein that induces DNA fragmentation and apoptosis. Shi, L., Kraut, R.P., Aebersold, R., Greenberg, A.H. J. Exp. Med. (1992) [Pubmed]
  8. Antigenic changes of L5178Y lymphoma after treatment with 5-(3,3-dimethyl-1-triazeno) imidazole-4-carboxamide in vivo. Nicolin, A., Spreafico, F., Bonmassar, E., Goldin, A. J. Natl. Cancer Inst. (1976) [Pubmed]
  9. The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules. Khodjakov, A., Rieder, C.L. J. Cell Biol. (1999) [Pubmed]
  10. Effect of DDAVP on endotoxin-induced intravascular coagulation in rabbits. Paloma, M.J., Páramo, J.A., Rocha, E. Thromb. Haemost. (1992) [Pubmed]
  11. Symmetrical peripheral gangrene: association with noradrenaline administration. Hayes, M.A., Yau, E.H., Hinds, C.J., Watson, J.D. Intensive care medicine. (1992) [Pubmed]
  12. A contribution to the pathology of acquired plasma factor XIII deficiency. Ballerini, G., Guerra, S., Rodeghiero, F., Castaman, G. Semin. Thromb. Hemost. (1985) [Pubmed]
  13. Substitution of antithrombin III in shock and DIC: a randomized study. Blauhut, B., Kramar, H., Vinazzer, H., Bergmann, H. Thromb. Res. (1985) [Pubmed]
  14. Cephaloridine nephrotoxicity in diabetic rats: modulation by insulin treatment. Valentovic, M.A., Ball, J.G. Toxicology (1995) [Pubmed]
  15. Pit cells (Hepatic natural killer cells) of the rat induce apoptosis in colon carcinoma cells by the perforin/granzyme pathway. Vermijlen, D., Luo, D., Robaye, B., Seynaeve, C., Baekeland, M., Wisse, E. Hepatology (1999) [Pubmed]
  16. 3,4-dichloroisocoumarin-induced activation of the degradation of beta-casein by the bovine pituitary multicatalytic proteinase complex. Pereira, M.E., Nguyen, T., Wagner, B.J., Margolis, J.W., Yu, B., Wilk, S. J. Biol. Chem. (1992) [Pubmed]
  17. Immunologic cross-reactivity of antigen(s) induced by drug treatment in two leukemic sublines. Nicolin, A., Bini, A., Di Padova, F., Goldin, A. J. Immunol. (1976) [Pubmed]
  18. Structure of Tctex-1 and its interaction with cytoplasmic dynein intermediate chain. Mok, Y.K., Lo, K.W., Zhang, M. J. Biol. Chem. (2001) [Pubmed]
  19. XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover. Vasquez, R.J., Gard, D.L., Cassimeris, L. J. Cell Biol. (1994) [Pubmed]
  20. Cytoskeletal movements and substrate interactions during initiation of neurite outgrowth by sympathetic neurons in vitro. Smith, C.L. J. Neurosci. (1994) [Pubmed]
  21. Regenerated hair cells can originate from supporting cell progeny: evidence from phototoxicity and laser ablation experiments in the lateral line system. Balak, K.J., Corwin, J.T., Jones, J.E. J. Neurosci. (1990) [Pubmed]
  22. Microsomal metabolism of triazenylimidazoles. Hill, D.L. Cancer Res. (1975) [Pubmed]
  23. Proteasome-dependent endoplasmic reticulum-associated protein degradation: an unconventional route to a familiar fate. Werner, E.D., Brodsky, J.L., McCracken, A.A. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  24. Involvement of ceramide in hyperosmotic shock-induced death of erythrocytes. Lang, K.S., Myssina, S., Brand, V., Sandu, C., Lang, P.A., Berchtold, S., Huber, S.M., Lang, F., Wieder, T. Cell Death Differ. (2004) [Pubmed]
  25. Fas-mediated apoptosis in mouse hepatocytes involves the processing and activation of caspases. Jones, R.A., Johnson, V.L., Buck, N.R., Dobrota, M., Hinton, R.H., Chow, S.C., Kass, G.E. Hepatology (1998) [Pubmed]
  26. Inhibition of the proteolytic activity of the multicatalytic proteinase complex (proteasome) by substrate-related peptidyl aldehydes. Vinitsky, A., Cardozo, C., Sepp-Lorenzino, L., Michaud, C., Orlowski, M. J. Biol. Chem. (1994) [Pubmed]
  27. Tissue factor production not balanced by tissue factor pathway inhibitor in sepsis promotes poor prognosis. Gando, S., Kameue, T., Morimoto, Y., Matsuda, N., Hayakawa, M., Kemmotsu, O. Crit. Care Med. (2002) [Pubmed]
  28. Effect of FR167653, a cytokine suppressive agent, on endotoxin-induced disseminated intravascular coagulation. Yamamoto, N., Sakai, F., Yamazaki, H., Nakahara, K., Okuhara, M. Eur. J. Pharmacol. (1996) [Pubmed]
  29. Hair-forming activity of human lymphocyte specific protein 1 requires cooperation between its caldesmon-like domains and the villin headpiece-like domains. Zhang, Q., Li, Y., Howard, T.H. Cell Motil. Cytoskeleton (2001) [Pubmed]
  30. Gene targeting in hemostasis: protein C. Castellino, F.J. Front. Biosci. (2001) [Pubmed]
  31. Doublecortin, a stabilizer of microtubules. Horesh, D., Sapir, T., Francis, F., Wolf, S.G., Caspi, M., Elbaum, M., Chelly, J., Reiner, O. Hum. Mol. Genet. (1999) [Pubmed]
  32. Organelle movements in the wild type and wall-less fz;sg;os-1 mutants of Neurospora crassa are mediated by cytoplasmic microtubules. Steinberg, G., Schliwa, M. J. Cell. Sci. (1993) [Pubmed]
  33. Tissue factor released from leukemic cells. Kubota, T., Andoh, K., Sadakata, H., Tanaka, H., Kobayashi, N. Thromb. Haemost. (1991) [Pubmed]
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