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Chemical Compound Review:

Methylparaoxon 1-dimethoxyphosphoryloxy-4- nitro-benzene

Synonyms: Methyl-E-600, CHEMBL26115, PS613_SUPELCO, SureCN901276, BAY 11678, ...

Silva Filho, M.V. et al., Küster, E. et al., Blasiak, J., Albores, A. et al., Yamamoto, T. et al.

Albores, Ortega-Mantilla, Sierra-Santoyo, Cebrián, Muñoz-Sánchez, Calderón-Salinas, Manno,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Desmethylnitrophos

These results predict that the amino acid sequence involved in AChE sensitivity differs in these fishes, and that consequently some fish species may be resistant to the toxicity of methyl-paraoxon [1].

High impact information on Desmethylnitrophos

Visual effects of exposure to the organophosphate metabolite paraoxon-methyl after 24 and 48 h in the zebra fish embryo test system were analysed with the use of an inverse microscope (rate of mortality, developmental disturbances, heart rate and others) [2].
Acetylcholinesterase (AChE) sensitivity to the organophosphorus (OP) pesticide methyl-paraoxon was measured in fourteen species of Neotropical marine and freshwater fish found in the waters of Brazil [1].
Methyl-paraoxon comparative inhibition kinetics for acetylcholinesterases from brain of neotropical fishes [1].
As expected, in incubations of rat brain extract supplemented with NADPH, AChE activity was non-competitively inhibited by the presence of MePA, indicating that MePA was activated to its reactive metabolite methyl-paraoxon (MePO) [3].
Methylparathion and methylparaoxon inhibited the chloride equilibrium exchange in erythrocyte ghosts in a dose- and time-dependent manner [4].

Chemical compound and disease context of Desmethylnitrophos

The difference in the acute toxicity of the insecticides could be the more rapid decomposition of fenitrothion and fenitrooxon in rat liver than that of methylparathion and methylparaoxon [5].

Anatomical context of Desmethylnitrophos

Methylparathion and methylparaoxon might inhibit the anion exchange indirectly by changing the fluidity of the erythrocyte membrane or directly by binding to the band 3 protein and evoking conformational changes that lead to the inhibition of the anion transport [4].

Analytical, diagnostic and therapeutic context of Desmethylnitrophos

Comparison of cholin- and carboxylesterase enzyme inhibition and visible effects in the zebra fish embryo bioassay under short-term paraoxon-methyl exposure [2].

References

Methyl-paraoxon comparative inhibition kinetics for acetylcholinesterases from brain of neotropical fishes. Silva Filho, M.V., Oliveira, M.M., Salles, J.B., Bastos, V.L., Cassano, V.P., Bastos, J.C. Toxicol. Lett. (2004) [Pubmed]
Comparison of cholin- and carboxylesterase enzyme inhibition and visible effects in the zebra fish embryo bioassay under short-term paraoxon-methyl exposure. Küster, E., Altenburger, R. Biomarkers (2006) [Pubmed]
Cytochrome P450 2B (CYP2B)-mediated activation of methyl-parathion in rat brain extracts. Albores, A., Ortega-Mantilla, G., Sierra-Santoyo, A., Cebrián, M.E., Muñoz-Sánchez, J.L., Calderón-Salinas, J.V., Manno, M. Toxicol. Lett. (2001) [Pubmed]
Comparison of the action of an organophosphorus insecticide and its metabolite on chloride and sulfate transport in erythrocyte membrane. Blasiak, J. Z. Naturforsch., C, J. Biosci. (1996) [Pubmed]
Comparative metabolism of fenitrothion and methylparathion in male rats. Yamamoto, T., Egashira, T., Yoshida, T., Kuroiwa, Y. Acta pharmacologica et toxicologica. (1983) [Pubmed]

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