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Chemical Compound Review

Methylparaoxon     1-dimethoxyphosphoryloxy-4- nitro-benzene

Synonyms: Methyl-E-600, CHEMBL26115, PS613_SUPELCO, SureCN901276, BAY 11678, ...
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Disease relevance of Desmethylnitrophos


High impact information on Desmethylnitrophos

  • Visual effects of exposure to the organophosphate metabolite paraoxon-methyl after 24 and 48 h in the zebra fish embryo test system were analysed with the use of an inverse microscope (rate of mortality, developmental disturbances, heart rate and others) [2].
  • Acetylcholinesterase (AChE) sensitivity to the organophosphorus (OP) pesticide methyl-paraoxon was measured in fourteen species of Neotropical marine and freshwater fish found in the waters of Brazil [1].
  • Methyl-paraoxon comparative inhibition kinetics for acetylcholinesterases from brain of neotropical fishes [1].
  • As expected, in incubations of rat brain extract supplemented with NADPH, AChE activity was non-competitively inhibited by the presence of MePA, indicating that MePA was activated to its reactive metabolite methyl-paraoxon (MePO) [3].
  • Methylparathion and methylparaoxon inhibited the chloride equilibrium exchange in erythrocyte ghosts in a dose- and time-dependent manner [4].

Chemical compound and disease context of Desmethylnitrophos


Anatomical context of Desmethylnitrophos

  • Methylparathion and methylparaoxon might inhibit the anion exchange indirectly by changing the fluidity of the erythrocyte membrane or directly by binding to the band 3 protein and evoking conformational changes that lead to the inhibition of the anion transport [4].

Analytical, diagnostic and therapeutic context of Desmethylnitrophos


  1. Methyl-paraoxon comparative inhibition kinetics for acetylcholinesterases from brain of neotropical fishes. Silva Filho, M.V., Oliveira, M.M., Salles, J.B., Bastos, V.L., Cassano, V.P., Bastos, J.C. Toxicol. Lett. (2004) [Pubmed]
  2. Comparison of cholin- and carboxylesterase enzyme inhibition and visible effects in the zebra fish embryo bioassay under short-term paraoxon-methyl exposure. Küster, E., Altenburger, R. Biomarkers (2006) [Pubmed]
  3. Cytochrome P450 2B (CYP2B)-mediated activation of methyl-parathion in rat brain extracts. Albores, A., Ortega-Mantilla, G., Sierra-Santoyo, A., Cebrián, M.E., Muñoz-Sánchez, J.L., Calderón-Salinas, J.V., Manno, M. Toxicol. Lett. (2001) [Pubmed]
  4. Comparison of the action of an organophosphorus insecticide and its metabolite on chloride and sulfate transport in erythrocyte membrane. Blasiak, J. Z. Naturforsch., C, J. Biosci. (1996) [Pubmed]
  5. Comparative metabolism of fenitrothion and methylparathion in male rats. Yamamoto, T., Egashira, T., Yoshida, T., Kuroiwa, Y. Acta pharmacologica et toxicologica. (1983) [Pubmed]
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