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Chemical Compound Review

Metaphos     dimethoxy-(4-nitrophenoxy)- sulfanylidene...

Synonyms: Metacide, Metaphor, Vofatox, Wofatox, Dalf, ...
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Disease relevance of Parathion methyl


Psychiatry related information on Parathion methyl

  • From these facts, we assumed that the deterioration of sleep at the 20- and 30-m nitrox saturation dives was predominantly relative to being restricted in a closed environment for a long time and the lack of physical activity of the divers [5].
  • Measures of reaction time, response accuracy, anxiety, hostility, and depression were obtained from three U.S. Navy divers (Ss) during a nitrox saturation dive at 7 ATA (bottom time 7 days) [6].

High impact information on Parathion methyl

  • We provide evidence that Metron factor 1 prevents apoptosis and stimulates cell proliferation at nanomolar concentrations, but is devoid of any pro-invasive activity [7].
  • CDC used a new biological monitoring method to measure urinary p-nitrophenol (PNP), the metabolite of MP [8].
  • The mutation was mapped to a Drosophila homolog of human AF10/AF17 leukemia fusion genes (alf), and therefore named Dalf [9].
  • In addition to the embryonic phenotype, Dalf mutant larvae are retarded in their growth and this defect can be rescued by the ectopic expression of a Dalf transgene under the control of a neuronal GAL4 driver [9].
  • Like its human counterparts, Dalf encodes a zinc finger/leucine zipper nuclear protein that is widely expressed in embryonic and larval tissues including neurons and glia [9].

Chemical compound and disease context of Parathion methyl


Biological context of Parathion methyl


Anatomical context of Parathion methyl


Associations of Parathion methyl with other chemical compounds

  • The reactions of five organophosphorus insecticides (OPs) (chlorpyrifos-methyl, parathion-methyl, fenchlorphos, chlorpyrifos, and parathion) with hydrogensulfide/ bisulfide (H2S/HS-) and polysulfides (S(n)2-) were examined in well-defined aqueous solutions over a pH range from 5 to 9 [22].
  • For pesticides, first experiments showed that paraoxon-methyl inhibits C. vulgaris AChE contrary to parathion-methyl and carbofuran [23].
  • We have successfully detected algae in every sample that we examined and readily monitored changes in the characteristic fluorescence induction curves when the samples were exposed to potassium cyanide (KCN), methyl parathion (MPt), N'(3,4-dichlorophenyl)-N,N-dimethylurea (DCMU), and paraquat [24].
  • The pigs were anesthetized with ketamine and alpha-chloralose and compressed in a hyperbaric chamber to 500 kPa (40 m of seawater) in 2 min, and they had 3-h bottom time while breathing nitrox (35 kPa O(2)) [25].
  • A mechanistic approach using a laminar air-boundary layer concept to predict volatilization from plant surfaces was compared to data obtained in a wind-tunnel study after simultaneous application of parathion-methyl, fenpropimorph, and quinoxyfen to winter wheat [26].

Gene context of Parathion methyl

  • No studies have yet determined the relative activities of human GSTM1, T1 or PI towards methylparathion or other pesticides, and thus the potential significance of the common polymorphisms of these genes on pesticide susceptibility is unknown [27].
  • Methyl-parathion and organophosphorous pesticide metabolites modify the activation status and interleukin-2 secretion of human peripheral blood mononuclear cells [28].
  • In Dalf mutant embryos, the RP2 motoneuron no longer maintains EVE expression [9].
  • Effect of chronic consumption of methylparathion on rat brain regional acetylcholinesterase activity and on levels of biogenic amines [29].
  • The first study, carried out in the Ivory Coast, involved the application of an endrin/DDT/methylparathion (MEP) formulation in an aromatic hydrocarbon solvent [30].

Analytical, diagnostic and therapeutic context of Parathion methyl


  1. Mosaic prophages with horizontally acquired genes account for the emergence and diversification of the globally disseminated M1T1 clone of Streptococcus pyogenes. Aziz, R.K., Edwards, R.A., Taylor, W.W., Low, D.E., McGeer, A., Kotb, M. J. Bacteriol. (2005) [Pubmed]
  2. Mutagenicity of some organophosphorus compounds at the ade6 locus of Schizosaccharomyces pombe. Gilot-Delhalle, J., Colizzi, A., Moutschen, J., Moutschen-Dahmen, M. Mutat. Res. (1983) [Pubmed]
  3. Cytogeneticity of quinalphos and methyl parathion in human peripheral lymphocytes. Rupa, D.S., Reddy, P.P., Reddi, O.S. Human & experimental toxicology. (1990) [Pubmed]
  4. Transient opsoclonus in organophosphate poisoning. De Bleecker, J.L. Acta neurologica Scandinavica. (1992) [Pubmed]
  5. Changes in sleep patterns during simulated nitrox saturation diving to 20 and 30 meters. Nagashima, H., Matsumoto, K., Seo, Y.J., Mohri, M., Naraki, N., Matsuoka, S. Perceptual and motor skills. (2002) [Pubmed]
  6. Diver adaptability during a nitrox saturation dive at 7 ATA. Weybrew, B.B. Undersea biomedical research. (1978) [Pubmed]
  7. An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity. Michieli, P., Cavassa, S., Basilico, C., De Luca, A., Mazzone, M., Asti, C., Chiusaroli, R., Guglielmi, M., Bossù, P., Colotta, F., Caselli, G., Comoglio, P.M. Nat. Biotechnol. (2002) [Pubmed]
  8. Public health decisions: the laboratory's role in the Lorain County, Ohio, investigation. Hill, R.H., Head, S., Barr, D.B., Rubin, C., Esteban, E., Baker, S.E., Bailey, S., Needham, L.L. Environ. Health Perspect. (2002) [Pubmed]
  9. The Drosophila homolog of human AF10/AF17 leukemia fusion genes (Dalf) encodes a zinc finger/leucine zipper nuclear protein required in the nervous system for maintaining EVE expression and normal growth. Bahri, S.M., Chia, W., Yang, X. Mech. Dev. (2001) [Pubmed]
  10. The effect of glutathione monoethyl ester on the potentiation of the acute toxicity of methyl parathion, methyl paraoxon or fenitrothion by diethyl maleate in the mouse. Sultatos, L.G., Huang, G.J., Jackson, O., Reed, K., Soranno, T.M. Toxicol. Lett. (1991) [Pubmed]
  11. Acute toxicity of several organophosphorous insecticides and protection by cholinergic antagonists and 2-PAM on Artemia salina larvae. Sánchez-Fortún, S., Sanz, F., Barahona, M.V. Arch. Environ. Contam. Toxicol. (1996) [Pubmed]
  12. Absence of antiarrhythmic effects of helium in patients with spontaneous premature ventricular beats at rest. Wade, C.E., Banister, E.W., Baker, D.G., Lin, Y.C. Undersea biomedical research. (1979) [Pubmed]
  13. Growth, chlorophyll a content, nitrogen-fixing ability, and certain metabolic activities of Nostoc muscorum: effect of methylparathion and benthiocarb. Bhunia, A.K., Basu, N.K., Roy, D., Chakrabarti, A., Banerjee, S.K. Bulletin of environmental contamination and toxicology. (1991) [Pubmed]
  14. Behaviour and indicator value of some microorganisms under conditions of soil contamination by pesticides. Yurovskaya, E.M. Journal of hygiene, epidemiology, microbiology, and immunology. (1975) [Pubmed]
  15. Remarkably efficient hydrolysis of methylparathion catalyzed by [2-(2-pyridyl)phenyl-C,N]palladium(II) complexes. Kim, M., Picot, A., Gabbaï, F.P. Inorganic chemistry. (2006) [Pubmed]
  16. Cytogenetic study of workers exposed to methyl-parathion. de Cassia Stocco, R., Beçak, W., Gaeta, R., Rabello-Gay, M.N. Mutat. Res. (1982) [Pubmed]
  17. Induction of sister-chromatid exchanges and cell cycle delay in cultured mammalian cells treated with eight organophosphorus pesticides. Chen, H.H., Hsueh, J.L., Sirianni, S.R., Huang, C.C. Mutat. Res. (1981) [Pubmed]
  18. Genetic damage caused by methyl-parathion in mouse spermatozoa is related to oxidative stress. Pi??a-Guzm??n, B., Sol??s-Heredia, M.J., Rojas-Garc??a, A.E., Uri??stegui-Acosta, M., Quintanilla-Vega, B. Toxicol. Appl. Pharmacol. (2006) [Pubmed]
  19. Neurophysiological markers as early signs of organophosphate neurotoxicity. Nagymajtényi, L., Dési, I., Lorencz, R. Neurotoxicology and teratology. (1988) [Pubmed]
  20. In vitro cytotoxicity of the organophosphorus insecticide methylparathion to FG-9307, the gill cell line of flounder (Paralichthys olivaceus). Li, H., Zhang, S. Cell Biol. Toxicol. (2002) [Pubmed]
  21. Immunotoxicological assessment of methyl parathion in female B6C3F1 mice. Crittenden, P.L., Carr, R., Pruett, S.B. J. Toxicol. Environ. Health Part A (1998) [Pubmed]
  22. Nucleophilic substitution of phosphorothionate ester pesticides with bisulfide (HS-) and polysulfides (S(n)2-). Wu, T., Gan, Q., Jans, U. Environ. Sci. Technol. (2006) [Pubmed]
  23. A bi-enzymatic whole cell conductometric biosensor for heavy metal ions and pesticides detection in water samples. Chouteau, C., Dzyadevych, S., Durrieu, C., Chovelon, J.M. Biosensors & bioelectronics. (2005) [Pubmed]
  24. Biosensors for rapid monitoring of primary-source drinking water using naturally occurring photosynthesis. Rodriguez, M., Sanders, C.A., Greenbaum, E. Biosensors & bioelectronics. (2002) [Pubmed]
  25. Effect of a short-acting NO donor on bubble formation from a saturation dive in pigs. M??llerl??kken, A., Berge, V.J., J??rgensen, A., Wisl??ff, U., Brubakk, A.O. J. Appl. Physiol. (2006) [Pubmed]
  26. Pesticide volatilization from plants: improvement of the PEC model PELMO based on a boundary-layer concept. Wolters, A., Leistra, M., Linnemann, V., Klein, M., Schäffer, A., Vereecken, H. Environ. Sci. Technol. (2004) [Pubmed]
  27. Biotransformation enzyme polymorphism and pesticide susceptibility. Eaton, D.L. Neurotoxicology (2000) [Pubmed]
  28. Methyl-parathion and organophosphorous pesticide metabolites modify the activation status and interleukin-2 secretion of human peripheral blood mononuclear cells. Lima, A., Vega, L. Toxicol. Lett. (2005) [Pubmed]
  29. Effect of chronic consumption of methylparathion on rat brain regional acetylcholinesterase activity and on levels of biogenic amines. Kumar, M.V., Desiraju, T. Toxicology (1992) [Pubmed]
  30. Field studies on health effects from the application of two organophosphorus insecticide formulations by hand-held ULV to cotton. Kummer, R., van Sittert, N.J. Toxicol. Lett. (1986) [Pubmed]
  31. Plasma perfusion through charcoal in methylparathion poisoning. Luzhnikov, E.A., Yaroslavsky, A.A., Molodenkov, M.N., Shurkalin, B.K., Evseev, N.G., Barsukov, U.F. Lancet (1977) [Pubmed]
  32. High-frequency jet ventilation with helium and oxygen (heliox) versus nitrogen and oxygen (nitrox). Cros, A.M., Guenard, H., Boudey, C. Anesthesiology (1988) [Pubmed]
  33. Nitrogen purity influences the occurrence of As+ ions in high-performance liquid chromatography/electrospray ionization mass spectrometric analysis of four common arsenosugars. Kuehnelt, D., Goessler, W., Francesconi, K.A. Rapid Commun. Mass Spectrom. (2003) [Pubmed]
  34. Fluorescence polarization immunoassay based on a monoclonal antibody for the detection of the organophosphorus pesticide parathion-methyl. Kolosova, A.Y., Park, J.H., Eremin, S.A., Kang, S.J., Chung, D.H. J. Agric. Food Chem. (2003) [Pubmed]
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