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Chemical Compound Review

Acethydrazide     ethanehydrazide

Synonyms: Acetohydrazide, A8309_ALDRICH, AGN-PC-0CS0YY, NSC-2271, ACMC-1BS4X, ...
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Disease relevance of ethanehydrazide


High impact information on ethanehydrazide


Chemical compound and disease context of ethanehydrazide

  • Using a model of INH-induced hepatotoxicity in rabbits, in which INH-induced hepatotoxicity manifests as hepatic necrosis, hepatic steatosis (hepatic fat accumulation) and hypertriglyceridaemia (elevated plasma triglycerides), we compared the severity of these measures of toxicity with plasma levels of INH, acetylhydrazine and hydrazine [7].

Biological context of ethanehydrazide

  • Comparison of urinary metabolites of isoniazid at two dose levels indicated that acetylation of acetylhydrazine produced as a metabolite may be inhibited by the parent drug [8].
  • When acetyl-INH was administered, covalent hepatic protein binding of the acetyl moiety was greater in the rabbit than the rat, but the opposite was observed when acetylhydrazine was administered [9].

Associations of ethanehydrazide with other chemical compounds


Gene context of ethanehydrazide

  • When this antimode was used, the mean apparent kinetic variables of INH and acetyl INH estimated from the plasma concentration-time data and the mean values for the 24-h urinary amount of INH and its metabolites, except for monoacetylhydrazine (P less than 0.05), did not significantly differ between the rapid acetylators of SLE and control groups [11].


  1. Relationship between N-acetylator phenotype and susceptibility toward hydrazine-induced lethal central nervous system toxicity in the rabbit. Hein, D.W., Weber, W.W. J. Pharmacol. Exp. Ther. (1984) [Pubmed]
  2. Cimetidine inhibits the formation of the reactive, toxic metabolite of isoniazid in rats but not in man. Lauterburg, B.H., Todd, E.L., Smith, C.V., Mitchell, J.R. Hepatology (1985) [Pubmed]
  3. Oxidation of hydrazine metabolites formed from isoniazid. Lauterburg, B.H., Smith, C.V., Todd, E.L., Mitchell, J.R. Clin. Pharmacol. Ther. (1985) [Pubmed]
  4. Chlamydomonas alpha-tubulin is posttranslationally modified by acetylation on the epsilon-amino group of a lysine. L'Hernault, S.W., Rosenbaum, J.L. Biochemistry (1985) [Pubmed]
  5. Spin trapping of free radical intermediates produced during the metabolism of isoniazid and iproniazid in isolated hepatocytes. Albano, E., Tomasi, A. Biochem. Pharmacol. (1987) [Pubmed]
  6. Determination of isoniazid, acetylisoniazid, acetylhydrazine and diacetylhydrazine in biological fluids by high-performance liquid chromatography. von Sassen, W., Castro-Parra, M., Musch, E., Eichelbaum, M. J. Chromatogr. (1985) [Pubmed]
  7. Role of hydrazine in the mechanism of isoniazid hepatotoxicity in rabbits. Sarich, T.C., Youssefi, M., Zhou, T., Adams, S.P., Wall, R.A., Wright, J.M. Arch. Toxicol. (1996) [Pubmed]
  8. Studies on the effects of isoniazid on acetylhydrazine metabolism in vivo and in vitro. Timbrell, J.A., Wright, J.M. Drug Metab. Dispos. (1979) [Pubmed]
  9. Metabolism of [14C]acetylisoniazid and [14C]acetylhydrazine by the rat and rabbit. Thomas, B.H., Whitehouse, L.W., Zeitz, W. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1984) [Pubmed]
  10. Factors affecting the metabolism of [14C]acetylhydrazine in rats. Wright, J.M., Timbrell, J.A. Drug Metab. Dispos. (1978) [Pubmed]
  11. Isoniazid disposition, comparison of isoniazid phenotyping methods in and acetylator distribution of Japanese patients with idiopathic systemic lupus erythematosus and control subjects. Horai, Y., Ishizaki, T., Sasaki, T., Koya, G., Matsuyama, K., Iguchi, S. British journal of clinical pharmacology. (1982) [Pubmed]
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