Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Glycomul P [2-[(2R,3S,4R)-3,4- dihydroxyoxolan-2-yl]-2...

Synonyms: Liposorb P, Crill 2, Arlacel 40, Montane 40, Protachem SMP, ...

Pasche-Koo, F. et al., Shen, W.W. et al., Korhonen, M. et al., Huang, Y.Z. et al., Varshosaz, J. et al.

Varshosaz, Pardakhty, Baharanchi, Korhonen, Hirvonen, Peltonen, Antikainen, Yrjänäinen, Yliruusi,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Crill 2

To study the sensitization rate in a population with frequent use of these agents, we selected 47 patients with chronic or recurrent (> 1 year) inflammatory skin disease (leg ulcers, contact dermatitis, atopic dermatitis, psoriasis) for patch testing with the following emulsifiers: Tween 40 (polyoxyethylene sorbitan monopalmitate) [1].

High impact information on Crill 2

Percutaneous absorption of sodium salicylate was increased significantly when sorbitan monolaurate, sorbitan monopalmitate, or poloxamer 182 was added to the ointment containing dimethyl sulfoxide, sodium salicylate, and white petrolatum [2].
The effect of molecular structure of four sorbitan monoester surfactants (sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate and sorbitan monooleate) on the formation of simple three-component creams is presented [3].
CLs modified with Span 40 significantly facilitated the cellular uptake by COS-7 cells and HeLa cells; also showed some positive effect on gene expression [4].
A proniosomal gel for transdermal drug delivery of chlorpheniramine maleate (CPM) was developed based on Span 40 and extensively characterized in vitro [5].

References

High sensitization rate to emulsifiers in patients with chronic leg ulcers. Pasche-Koo, F., Piletta, P.A., Hunziker, N., Hauser, C. Contact Derm. (1994) [Pubmed]
Effect of nonionic surfactants on percutaneous absorption of salicylic acid and sodium salicylate in the presence of dimethyl sulfoxide. Shen, W.W., Danti, A.G., Bruscato, F.N. Journal of pharmaceutical sciences. (1976) [Pubmed]
Formation and characterization of three-component-sorbitan monoester surfactant, oil and water-creams. Korhonen, M., Hirvonen, J., Peltonen, L., Antikainen, O., Yrjänäinen, L., Yliruusi, J. International journal of pharmaceutics. (2004) [Pubmed]
Cationic liposomes modified with non-ionic surfactants as effective non-viral carrier for gene transfer. Huang, Y.Z., Gao, J.Q., Chen, J.L., Liang, W.Q. Colloids and surfaces. B, Biointerfaces. (2006) [Pubmed]
Sorbitan monopalmitate-based proniosomes for transdermal delivery of chlorpheniramine maleate. Varshosaz, J., Pardakhty, A., Baharanchi, S.M. Drug delivery. (2005) [Pubmed]

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