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Chemical Compound Review

PDSP1_000612     (E)-4-(4-chlorophenoxy)-4- oxo-but-2-enoic...

Synonyms: PDSP2_000609, FT-0665005, AC1O623P
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Disease relevance of l-Chlorpheniramine maleate


High impact information on l-Chlorpheniramine maleate


Chemical compound and disease context of l-Chlorpheniramine maleate


Biological context of l-Chlorpheniramine maleate


Anatomical context of l-Chlorpheniramine maleate

  • Effect of the H1 antihistamine chlorpheniramine maleate on histamine-induced symptoms in the human conjunctiva. Indirect evidence for nervous H1 receptors [17].
  • Patients in Group A received DM 40 mg (containing CPM 20 mg) IM after removal of the gallbladder, whereas in Group B, DM 40 mg (containing CPM 20 mg) was administered IM 30 min before skin incision [18].
  • An antitussive compound of codeine sulfate and chlorpheniramine maleate was formulated in a coated drug-resin complex, which prevents release of the active ingredients until they reach the stomach and small intestine [19].
  • Moreover, with the deposit method, CM remaining in the nasal cavity exhibited a biphasic profile of disappearance, which complied with a saturated process [20].
  • To evaluate and compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamine (loratadine) on isolated trachea of rabbit [21].

Associations of l-Chlorpheniramine maleate with other chemical compounds


Gene context of l-Chlorpheniramine maleate


Analytical, diagnostic and therapeutic context of l-Chlorpheniramine maleate


  1. Effectiveness of antihistamines in the symptomatic management of the common cold. Howard, J.C., Kantner, T.R., Lilienfield, L.S., Princiotto, J.V., Krum, R.E., Crutcher, J.E., Belman, M.A., Danzig, M.R. JAMA (1979) [Pubmed]
  2. Comparison of azelastine and chlorpheniramine in the treatment of mastocytosis. Friedman, B.S., Santiago, M.L., Berkebile, C., Metcalfe, D.D. J. Allergy Clin. Immunol. (1993) [Pubmed]
  3. Bronchial hyperreactivity to histamine and methacholine in asthmatic children after inhalation of SCH 1000 and chlorpheniramine maleate. Woenne, R., Kattan, M., Orange, R.P., Levison, H. J. Allergy Clin. Immunol. (1978) [Pubmed]
  4. Management of ovarian hyperstimulation syndrome with chlorpheniramine maleate, mannitol, and invasive hemodynamic monitoring. Kirshon, B., Doody, M.C., Cotton, D.B., Gibbons, W. Obstetrics and gynecology. (1988) [Pubmed]
  5. Contact dermatitis due to chlorpheniramine maleate in eyedrops. Tosti, A., Bardazzi, F., Piancastelli, E. Contact Derm. (1990) [Pubmed]
  6. A dose-ranging study of the efficacy and safety of azelastine nasal spray in the treatment of seasonal allergic rhinitis with an acute model. Weiler, J.M., Meltzer, E.O., Benson, P.M., Weiler, K., Widlitz, M.D., Freitag, J. J. Allergy Clin. Immunol. (1994) [Pubmed]
  7. Differential cognitive effects of terfenadine and chlorpheniramine. Meador, K.J., Loring, D.W., Thompson, E.E., Thompson, W.O. J. Allergy Clin. Immunol. (1989) [Pubmed]
  8. Airway closure after antigen challenge in cynomolgus monkeys: effect of the histamine H1 receptor antagonist, chlorpheniramine maleate. Skeans, S., Lamca, J.E., House, A., Celly, C.S., Hey, J.A., Chapman, R.W. Int. Arch. Allergy Immunol. (2005) [Pubmed]
  9. Major Degradation Product Identified in Several Pharmaceutical Formulations against the Common Cold. Wong, J., Wiseman, L., Al-Mamoon, S., Cooper, T., Zhang, L.K., Chan, T.M. Anal. Chem. (2006) [Pubmed]
  10. A comparative study of clemastine ('Tavegil') and chlorpheniramine maleate in the treatment of hay fever. Sheriff, J.M., Wallace, M.G. Current medical research and opinion. (1976) [Pubmed]
  11. Controlled trial of terfenadine and chlorpheniramine maleate in perennial rhinitis. Brostoff, J., Lockhart, J.D. Postgraduate medical journal. (1982) [Pubmed]
  12. The protective effect of inhaled chlorpheniramine and atropine on bronchoconstriction stimulated by airway cooling. O'Byrne, P.M., Thomson, N.C., Morris, M., Roberts, R.S., Daniel, E.E., Hargreave, F.E. Am. Rev. Respir. Dis. (1983) [Pubmed]
  13. Nonprescription chlorpheniramine maleate and submaximal exercise responses. Peterlin, M.F., Keyser, R.E., Andres, F.F., Sherman, G. Archives of physical medicine and rehabilitation. (1998) [Pubmed]
  14. Quantitation of cutaneous inflammation induced by reactive species generated by UV-visible irradiation of rose bengal. Ranadive, N.S., Menon, I.A., Shirwadkar, S., Persad, S.D. Inflammation (1989) [Pubmed]
  15. Synthesis and pharmacological investigation of some novel 2-methyl-3-(substituted methylamino)-(3H)-quinazolin-4-ones as histamine H1-receptor blockers. Alagarsamy, V. Die Pharmazie. (2004) [Pubmed]
  16. In vitro release studies of chlorpheniramine maleate from gels prepared by different cellulose derivatives. Tas, C., Ozkan, Y., Savaser, A., Baykara, T. Farmaco (2003) [Pubmed]
  17. Effect of the H1 antihistamine chlorpheniramine maleate on histamine-induced symptoms in the human conjunctiva. Indirect evidence for nervous H1 receptors. Kirkegaard, J., Secher, C., Mygind, N. Allergy (1982) [Pubmed]
  18. Preincisional dextromethorphan treatment decreases postoperative pain and opioid requirement after laparoscopic cholecystectomy. Wu, C.T., Yu, J.C., Yeh, C.C., Liu, S.T., Li, C.Y., Ho, S.T., Wong, C.S. Anesth. Analg. (1999) [Pubmed]
  19. Taste preference for cough syrups: a comparative study of three codeine-containing medications. Weintraub, M., Moscucci, M. Clinical therapeutics. (1986) [Pubmed]
  20. Prolonged release of drug from O/w emulsion and residence in rat nasal cavity. Aikawa, K., Matsumoto, K., Uda, H., Tanaka, S., Shimamura, H., Aramaki, Y., Tsuchiya, S. Pharmaceutical development and technology. (1998) [Pubmed]
  21. To evaluate and compare the effects of first generation anti-histamine (chlorpheniramine maleate) and second generation anti-histamine (loratadine) on isolated trachea of rabbit. Jalbani, G.A., Aamir, K., Shaikh, A.M., Unar, M.A., Ashraf, R., Soomro, F.M. JPMA. The Journal of the Pakistan Medical Association. (2004) [Pubmed]
  22. Multicenter, double-blind, multiple-dose, parallel-groups efficacy and safety trial of azelastine, chlorpheniramine, and placebo in the treatment of spring allergic rhinitis. Weiler, J.M., Donnelly, A., Campbell, B.H., Connell, J.T., Diamond, L., Hamilton, L.H., Rosenthal, R.R., Hemsworth, G.R., Perhach, J.L. J. Allergy Clin. Immunol. (1988) [Pubmed]
  23. Full and fractionated experimental designs for robustness testing in the high-performance liquid chromatographic analysis of codeine phosphate, pseudoephedrine hydrochloride and chlorpheniramine maleate in a pharmaceutical preparation. Ragonese, R., Mulholland, M., Kalman, J. Journal of chromatography. A. (2000) [Pubmed]
  24. Analysis of multicomponent formulations containing pseudoephedrine HCl and chlorpheniramine maleate using first-derivative spectroscopy on a diode-array spectrophotometer. Hoover, J.M., Soltero, R.A., Bansal, P.C. Journal of pharmaceutical sciences. (1987) [Pubmed]
  25. Automated drug dissolution monitor that uses a UV-visible diode array spectrophotometer. Lo, S.C., Donahue, S.M., Brown, C.W. Journal of pharmaceutical sciences. (1993) [Pubmed]
  26. Simultaneous assay of phenylpropanolamine hydrochloride, caffeine, paracetamol, glycerylguaiacolate and chlorpheniramine maleate in Silabat tablet using HPLC with diode array detection. Indrayanto, G., Sunarto, A., Adriani, Y. Journal of pharmaceutical and biomedical analysis. (1995) [Pubmed]
  27. Changes in adrenal neuropeptides content [peptide 7B2, neuropeptide Y (NPY) and vasoactive intestinal polypeptide (VIP)] induced by pharmacological and hormonal manipulations. Tsuchiya, T., Suzuki, Y., Suzuki, H., Ohtake, R., Shimoda, S.I. J. Endocrinol. Invest. (1990) [Pubmed]
  28. Development of a novel controlled-release system for gastric retention. Deshpande, A.A., Shah, N.H., Rhodes, C.T., Malick, W. Pharm. Res. (1997) [Pubmed]
  29. Skin permeation of chlorpheniramine maleate and detection of demethylated metabolites by high-performance liquid chromatography. Zbaida, S., Touitou, E. Journal of pharmaceutical sciences. (1988) [Pubmed]
  30. IR and X-ray diffraction study of chlorpheniramine maleate-montmorillonite interaction. Sánchez Camazano, M., Sánchez, M.J., Vicente, M.T., Domínguez-Gil, A. Journal of pharmaceutical sciences. (1980) [Pubmed]
  31. Premedication with dextromethorphan provides posthemorrhoidectomy pain relief. Liu, S.T., Wu, C.T., Yeh, C.C., Ho, S.T., Wong, C.S., Jao, S.W., Wu, C.C., Kang, J.C. Dis. Colon Rectum (2000) [Pubmed]
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