Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AG-E-95072 (2S,3S,4R,5R)-2,4,5,6- tetrahydroxy-3...

Synonyms: CTK1A3282, AC1L45KI, 2922-60-3, 3-O-Methylmannose, Mannose, 3-O-methyl-, ...

Tamura, T. et al., Weisman, L.S. et al., Weisman, L.S. et al., Lederkremer, G.Z. et al., Wheat, R.W. et al., et al.

Tamura, Hatano, Suzuki,

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of 3-O-Methylmannose

The methylmannose polysaccharide, found in the cytoplasm of Mycobacterium smegmatis, is composed of 3-O-methylmannose units joined in alpha 1----4 linkage in a chain terminated by unmethylated mannose at the nonreducing end [1].
Occurrence of 3-O-methylmannose in the polysaccharide of Leptospira biflexa Urawa [2].

High impact information on 3-O-Methylmannose

The labeled product formed from S-[methyl-3H]adenosylmethionine and Man-MeMan5-OCH3 was characterized both by its resistance to periodate oxidation and by the release of labeled 3-O-methylmannose upon acid hydrolysis [3].
The oligosaccharides with the highest content of 3-O-methylmannose residues appeared to be completely resistant to alpha-mannosidase degradation; they were, however, cleaved by endo-beta-N-acetylglucosaminidase H [4].
Skin test active fractions contained glucose, mannose, 3-O-methylmannose, glucosamine, and amino acids [5].
The isolates contained glutamic acid, glycine, alanine and meso-diaminopimelic acid in the cell wall, 3-O-methylmannose, mannose, galactose and glucose as the whole-cell sugars and MK-10(H(6)), MK-10(H(4)), MK-9(H(6)) and MK-9(H(4)) as the predominant isoprenoid quinones [6].

References

Biosynthesis of the mycobacterial methylmannose polysaccharide. Identification of an alpha 1----4-mannosyltransferase. Weisman, L.S., Ballou, C.E. J. Biol. Chem. (1984) [Pubmed]
Occurrence of 3-O-methylmannose in the polysaccharide of Leptospira biflexa Urawa. Azuma, I., Takeda, K., Yamamura, Y., Yanagihara, Y., Mifuchi, I. J. Bacteriol. (1976) [Pubmed]
Biosynthesis of the mycobacterial methylmannose polysaccharide. Identification of a 3-O-methyltransferase. Weisman, L.S., Ballou, C.E. J. Biol. Chem. (1984) [Pubmed]
3-O-methylation of mannose residues. A novel reaction in the processing of N-linked oligosaccharides occurring in Mucor rouxii. Lederkremer, G.Z., Parodi, A.J. J. Biol. Chem. (1984) [Pubmed]
Extraction of skin test activity from Coccidioides immitis mycelia by water, perchloric acid, and aqueous phenol extraction. Wheat, R.W., Su Chung, K.S., Ornellas, E.P., Scheer, E.R. Infect. Immun. (1978) [Pubmed]
A new genus of the family Micromonosporaceae, Polymorphospora gen. nov., with description of Polymorphospora rubra sp. nov. Tamura, T., Hatano, K., Suzuki, K. Int. J. Syst. Evol. Microbiol. (2006) [Pubmed]

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