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Gene Review

ENGASE  -  endo-beta-N-acetylglucosaminidase

Homo sapiens

Synonyms: Cytosolic endo-beta-N-acetylglucosaminidase, ENGase, FLJ21865
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Disease relevance of FLJ21865


High impact information on FLJ21865


Chemical compound and disease context of FLJ21865


Biological context of FLJ21865


Anatomical context of FLJ21865


Associations of FLJ21865 with chemical compounds


Other interactions of FLJ21865

  • At this time, MUC2 immunoprecipitated by anti-MUC2 was completely oligomerized and was endo-beta-N-acetylglucosaminidase-resistant, indicating that the mucin had reached the Golgi region [29].
  • Controlled deglycosylation using peptide : N-glycosidase F and endo-beta-N-acetylglucosaminidase F3 resulted in the formation of crystals of both hIL-10 : shIL-10R1 and vIL-10 : shIL-10R1 complexes, indicating that the difficulty in the crystal formation was largely due to the presence of complex carbohydrate side chains [30].
  • Treatment of the active high mannose receptor with endo-beta-N-acetylglucosaminidase H generates a fully active aglycoreceptor polypeptide, indicating that core oligosaccharide addition is a prerequisite for activation but that oligosaccharide chains are not intrinsically required for EGF binding [31].
  • The findings are consistent with the results obtained by endo-beta-N-acetylglucosaminidase F treatment of h-lamp-1 and h-lamp-2 precursors, described in the preceding paper (Carlsson, S. R., Roth, J., Piller, F., and Fukuda, M. (1988) J. Biol. Chem. 263, 18911-18919) [32].
  • On the other hand, oligosaccharides containing mannosyl, xylosyl, rhamnosyl, and ribosyl units were liberated from endo-beta-N-acetylglucosaminidase-resistant glycopeptides upon treatment with N-glycanase [33].

Analytical, diagnostic and therapeutic context of FLJ21865


  1. Staphylococcal endo-beta-N-acetylglucosaminidase inhibits response of human lymphocytes to mitogens and interferes with production of antibodies in mice. Valisena, S., Varaldo, P.E., Satta, G. J. Clin. Invest. (1991) [Pubmed]
  2. Enhanced transglycosylation activity of Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase in media containing organic solvents. Fan, J.Q., Takegawa, K., Iwahara, S., Kondo, A., Kato, I., Abeygunawardana, C., Lee, Y.C. J. Biol. Chem. (1995) [Pubmed]
  3. Urinary glycopeptides of fucosidosis. Yamashita, K., Tachibana, Y., Takada, S., Matsuda, I., Arashima, S., Kobata, A. J. Biol. Chem. (1979) [Pubmed]
  4. Effect of energy depletion on the glycosylation of a viral glycoprotein. Datema, R., Schwarz, R.T. J. Biol. Chem. (1981) [Pubmed]
  5. Intracellular transport of recombinant coronavirus spike proteins: implications for virus assembly. Vennema, H., Heijnen, L., Zijderveld, A., Horzinek, M.C., Spaan, W.J. J. Virol. (1990) [Pubmed]
  6. A study of the molecular pathology of sucrase-isomaltase deficiency. A defect in the intracellular processing of the enzyme. Lloyd, M.L., Olsen, W.A. N. Engl. J. Med. (1987) [Pubmed]
  7. Synthesis and intracellular processing of aminooligopeptidase by human intestine. Burke, T., Lloyd, M., Lorenzsonn, V., Olsen, W. Gastroenterology (1988) [Pubmed]
  8. Myeloperoxidase is synthesized as larger phosphorylated precursor. Hasilik, A., Pohlmann, R., Olsen, R.L., von Figura, K. EMBO J. (1984) [Pubmed]
  9. Synthesis of neoglycoconjugates by transglycosylation with Arthrobacter protophormiae endo-beta-N-acetylglucosaminidase. Demonstration of a macro-cluster effect for mannose-binding proteins. Fan, J.Q., Quesenberry, M.S., Takegawa, K., Iwahara, S., Kondo, A., Kato, I., Lee, Y.C. J. Biol. Chem. (1995) [Pubmed]
  10. Purification and characterization of adult diarrhea rotavirus: identification of viral structural proteins. Fang, Z.Y., Glass, R.I., Penaranda, M., Dong, H., Monroe, S.S., Wen, L., Estes, M.K., Eiden, J., Yolken, R.H., Saif, L. J. Virol. (1989) [Pubmed]
  11. Digestion of asparagine-linked oligosaccharides by endo-beta-N-acetylglucosaminidase in the human skin fibroblasts obtained from fucosidosis patients. Tachibana, Y., Yamashita, K., Kawaguchi, M., Arashima, S., Kobata, A. J. Biochem. (1981) [Pubmed]
  12. Chemo-enzymatic synthesis of eel calcitonin glycosylated at two sites with the same and different carbohydrate structures. Haneda, K., Takeuchi, M., Tagashira, M., Inazu, T., Toma, K., Isogai, Y., Hori, M., Kobayashi, K., Takeuchi, M., Takegawa, K., Yamamoto, K. Carbohydr. Res. (2006) [Pubmed]
  13. Transfer of Man9GlcNAc to L-fucose by endo-beta-N-acetylglucosaminidase from Arthrobacter protophormiae. Fan, J.Q., Huynh, L.H., Reinhold, B.B., Reinhold, V.N., Takegawa, K., Iwahara, S., Kondo, A., Kato, I., Lee, Y.C. Glycoconj. J. (1996) [Pubmed]
  14. Human lysosomal acid lipase/cholesteryl ester hydrolase. Purification and properties of the form secreted by fibroblasts in microcarrier culture. Sando, G.N., Rosenbaum, L.M. J. Biol. Chem. (1985) [Pubmed]
  15. Structural basis for the substrate specificity of endo-beta-N-acetylglucosaminidase F(3). Waddling, C.A., Plummer, T.H., Tarentino, A.L., Van Roey, P. Biochemistry (2000) [Pubmed]
  16. Heterologous expression of apolipoprotein B carboxyl-terminal truncates: a model for the study of lipoprotein biogenesis. Patel, S.B., Grundy, S.M. J. Lipid Res. (1995) [Pubmed]
  17. Mutations of endo-beta-N-acetylglucosaminidase H active site residueAs sp130 anG glu132: activities and conformations. Rao, V., Cui, T., Guan, C., Van Roey, P. Protein Sci. (1999) [Pubmed]
  18. Identification of an endo-beta-N-acetylglucosaminidase gene in Caenorhabditis elegans and its expression in Escherichia coli. Kato, T., Fujita, K., Takeuchi, M., Kobayashi, K., Natsuka, S., Ikura, K., Kumagai, H., Yamamoto, K. Glycobiology (2002) [Pubmed]
  19. Endo-beta-N-acetylglucosaminidase, an enzyme involved in processing of free oligosaccharides in the cytosol. Suzuki, T., Yano, K., Sugimoto, S., Kitajima, K., Lennarz, W.J., Inoue, S., Inoue, Y., Emori, Y. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  20. Biosynthesis of rice seed alpha-amylase: proteolytic processing and glycosylation of precursor polypeptides by microsomes. Miyata, S., Akazawa, T. J. Cell Biol. (1983) [Pubmed]
  21. Synthesis of beta-hexosaminidase in cell-free translation and in intact fibroblasts: an insoluble precursor alpha chain in a rare form of Tay-Sachs disease. Proia, R.L., Neufeld, E.F. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  22. Human thyroperoxidase in its alternatively spliced form (TPO2) is enzymatically inactive and exhibits changes in intracellular processing and trafficking. Niccoli, P., Fayadat, L., Panneels, V., Lanet, J., Franc, J.L. J. Biol. Chem. (1997) [Pubmed]
  23. Biosynthesis of glycosylated human lysozyme mutants. Horst, M., Harth, N., Hasilik, A. J. Biol. Chem. (1991) [Pubmed]
  24. Effect of lysosomotropic amines on the secretory pathway and on the recycling of the asialoglycoprotein receptor in human hepatoma cells. Strous, G.J., Du Maine, A., Zijderhand-Bleekemolen, J.E., Slot, J.W., Schwartz, A.L. J. Cell Biol. (1985) [Pubmed]
  25. Phosphorylated oligosaccharides in lysosomal enzymes: identification of alpha-N-acetylglucosamine(1)phospho(6)mannose diester groups. Hasilik, A., Klein, U., Waheed, A., Strecker, G., von Figura, K. Proc. Natl. Acad. Sci. U.S.A. (1980) [Pubmed]
  26. Two allelic forms of human arylsulfatase A with different numbers of asparagine-linked oligosaccharides. Waheed, A., Steckel, F., Hasilik, A., von Figura, K. Am. J. Hum. Genet. (1983) [Pubmed]
  27. Cell surface glycopeptides from human intestinal epithelial cell lines derived from normal colon and colon adenocarcinomas. Youakim, A., Herscovics, A. Cancer Res. (1985) [Pubmed]
  28. Identification, purification, and characterization of a stilbenedisulfonate binding glycoprotein from canine kidney brush border membranes. A candidate for a renal anion exchanger. Pimplikar, S.W., Reithmeier, R.A. J. Biol. Chem. (1988) [Pubmed]
  29. Roles of calreticulin and calnexin during mucin synthesis in LS180 and HT29/A1 human colonic adenocarcinoma cells. McCool, D.J., Okada, Y., Forstner, J.F., Forstner, G.G. Biochem. J. (1999) [Pubmed]
  30. Purification of receptor complexes of interleukin-10 stoichiometry and the importance of deglycosylation in their crystallization. Hoover, D.M., Schalk-Hihi, C., Chou, C.C., Menon, S., Wlodawer, A., Zdanov, A. Eur. J. Biochem. (1999) [Pubmed]
  31. Synthesis of epidermal growth factor receptor in human A431 cells. Glycosylation-dependent acquisition of ligand binding activity occurs post-translationally in the endoplasmic reticulum. Slieker, L.J., Martensen, T.M., Lane, M.D. J. Biol. Chem. (1986) [Pubmed]
  32. Cloning of cDNAs encoding human lysosomal membrane glycoproteins, h-lamp-1 and h-lamp-2. Comparison of their deduced amino acid sequences. Fukuda, M., Viitala, J., Matteson, J., Carlsson, S.R. J. Biol. Chem. (1988) [Pubmed]
  33. Novel (rhamnosyl and ribosyl) and uncommon (xylosyl) monosaccharide residues are present in asparagine-linked oligosaccharides of the trypanosomatid Blastocrithidia culicis. Merello, S., Xavier, M.T., Parodi, A.J. J. Biol. Chem. (1994) [Pubmed]
  34. Glucosidase II, a protein of the endoplasmic reticulum with high mannose oligosaccharide chains and a rapid turnover. Strous, G.J., Van Kerkhof, P., Brok, R., Roth, J., Brada, D. J. Biol. Chem. (1987) [Pubmed]
  35. 3-O-methylation of mannose residues. A novel reaction in the processing of N-linked oligosaccharides occurring in Mucor rouxii. Lederkremer, G.Z., Parodi, A.J. J. Biol. Chem. (1984) [Pubmed]
  36. The oligosaccharide moiety of the beta 1-adrenergic receptor from turkey erythrocytes has a biantennary, N-acetyllactosamine-containing structure. Cervantes-Olivier, P., Durieu-Trautmann, O., Delavier-Klutchko, C., Strosberg, A.D. Biochemistry (1985) [Pubmed]
  37. Effects of deoxymannojirimycin and castanospermine on the polarized secretion of thyroglobulin. Franc, J.L., Giraud, A., Lanet, J. Endocrinology (1990) [Pubmed]
  38. Identification of lectin-purified neural glycoproteins, GPs 180, 116, and 110, with NMDA and AMPA receptor subunits: conservation of glycosylation at the synapse. Clark, R.A., Gurd, J.W., Bissoon, N., Tricaud, N., Molnar, E., Zamze, S.E., Dwek, R.A., McIlhinney, R.A., Wing, D.R. J. Neurochem. (1998) [Pubmed]
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