Disease relevance of C03209

• The regulation of 2-hydroxybiphenyl and 2,2'-dihydroxybiphenyl degradation in Pseudomonas azelaica is mediated by the regulatory gene, hbpR [1].
• 2-Biphenylol, 3-biphenylol, 2,2'-biphenyldiol, 3,3'-biphenyldiol, 3-chloro-2-biphenylol, and 4,4'-dichloro-3-biphenylol were evaluated using the scrape-loading/dye transfer (SL/ DT) technique to determine in vitro gap junctional intercellular communication (GJIC) in a normal rat liver epithelial cell line as a measure of the epigenetic toxicity [2].

High impact information on C03209

• However, at high pH and phenol concentration, 2,2'-biphenol is the only identified coupled product, and its formation does not involve phenoxyl radicals [3].
• However, other metabolites resulting from hydroxylation of carbons 5 and 6 of 2,2'-dihydroxybiphenyl were also produced, leading to dead-end metabolites [4].
• Pseudomonas azelaica HBP1 can use 2-hydroxybiphenyl (2-HBP) and 2,2'-dihydroxybiphenyl as sole carbon and energy sources by means of the hbp regulon [5].
• Benzene and some of its metabolites (hydroquinone, phenol, catechol, 1,2,4-benzenetriol, p-benzoquinone, o,o'-biphenol, p,p'-biphenol) have been tested for their capability to induce micronuclei in bone marrow cells of pregnant mice and, transplacentally, in fetal liver cells [6].
• One oxidative coupling product, 2,2'-dihydroxybiphenyl, was obtained exclusively after adsorption at pH values above 7, and appeared both in aqueous solution and in the methanol regenerant solution [7].

Biological context of C03209

• Enzymic hydrolysis of the oxidized o,o'-biphenol-bound DNA also resulted in the release of the polymers [8].
• Phenoxyl dimerization in the RNase system produces the characteristic o,o'-biphenol fluorescence, but a competing interaction of the Tyr-25(phenoxyl) with the 26-84 disulphide group also appears possible [9].

References