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Chemical Compound Review:

Argininic acid (2S)-5- (diaminomethylideneamino)-2- hydroxy...

Synonyms: Arginic acid, AG-K-71220, HMDB03148, ANW-70617, KST-1A2418, ...

De Deyn, P.P. et al., De Deyn, P. et al., Zugno, A.I. et al., Balz, D. et al., De Deyn, P.P. et al., et al.

Wyse, Bavaresco, Hagen, Delwing, Wannmacher, Severo Dutra-Filho, Wajner,

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Disease relevance of Arginic acid

Tissue accumulation of arginine (Arg), N-acetylarginine (NA), argininic acid (AA) and homoarginine (HA) occurs in hyperargininemia, an inborn error of the urea cycle [1].

High impact information on Arginic acid

The results also showed a competition between guanidinoacetate and argininic acid (AA), suggesting a common binding site for the guanidino compounds (GC) on the enzyme [2].
In turn, argininic acid inhibited all enzyme activities, and its main action was also directed towards GSH-Px [3].
Before hemodialysis, high levels were found for guanidinosuccinic acid, N-alpha-acetylarginine, argininic acid, creatinine, gamma-guanidinobutyric acid, guanidine and methylguanidine [4].
The levels of argininic acid and N-alpha-acetylarginine (in serum) and gamma-guanidinobutyric acid (in cerebrospinal fluid) are slightly increased (less than 10 X) [5].

Chemical compound and disease context of Arginic acid

The guanidino compounds guanidine, methylguanidine, creatinine, guanidinosuccinic acid (increased in uremia) and arginine, homoarginine, alpha-keto-delta-guanidinovaleric acid and argininic acid (increased in hyperargininemia) decreased both GABA- and GLY-responses [6].

References

In vitro effects of L-arginine and guanidino compounds on NTPDase1 and 5'-nucleotidase activities from rat brain synaptosomes. Balz, D., de Souza Wyse, A.T., Morsch, V.M., da Silva, A.C., Vieira, V.L., Morsch, A.L., Schetinger, M.R. Int. J. Dev. Neurosci. (2003) [Pubmed]
Inhibition of Na+, K+-ATPase activity in rat striatum by guanidinoacetate. Zugno, A.I., Stefanello, F.M., Streck, E.L., Calcagnotto, T., Wannmacher, C.M., Wajner, M., Wyse, A.T. Int. J. Dev. Neurosci. (2003) [Pubmed]
In vitro stimulation of oxidative stress in cerebral cortex of rats by the guanidino compounds accumulating in hyperargininemia. Wyse, A.T., Bavaresco, C.S., Hagen, M.E., Delwing, D., Wannmacher, C.M., Severo Dutra-Filho, C., Wajner, M. Brain Res. (2001) [Pubmed]
Serum guanidino compound levels and the influence of a single hemodialysis in uremic patients undergoing maintenance hemodialysis. De Deyn, P., Marescau, B., Lornoy, W., Becaus, I., Van Leuven, I., Van Gorp, L., Lowenthal, A. Nephron (1987) [Pubmed]
Guanidino compounds in serum and cerebrospinal fluid of non-dialyzed patients with renal insufficiency. De Deyn, P.P., Marescau, B., Cuykens, J.J., Van Gorp, L., Lowenthal, A., De Potter, W.P. Clin. Chim. Acta (1987) [Pubmed]
Epilepsy and the GABA-hypothesis a brief review and some examples. De Deyn, P.P., Marescau, B., MacDonald, R.L. Acta neurologica Belgica. (1990) [Pubmed]

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