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Chemical Compound Review

Sulochrin     methyl 2-(2,6-dihydroxy-4-methyl...

Synonyms: CHEMBL61133, SureCN233392, AG-J-84156, CHEBI:16159, S4570_SIGMA, ...
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High impact information on C00495


Biological context of C00495


Anatomical context of C00495


Associations of C00495 with other chemical compounds

  • MATERIALS AND METHODS: We examined the effects of sulochrin on degranulation of human eosinophils stimulated with platelet-activating factor (PAF) or Sepharose 4B beads coated with secretory IgA (sIgA) or IgG [4].
  • The effects of sulochrin on other effector functions of human eosinophils, including superoxide anion (O2-) production, leukotriene (LT) C4 release, and interleukin (IL)-8 production induced by sIgA-beads were also studied [4].
  • Sulochrin oxidase, an enzyme catalyzing regio- and stereospecific phenol oxidative coupling reaction to form (+)-bisdechlorogeodin from sulochrin, was isolated from Penicillium frequentans CMI 96659 [5].
  • By chromatographies on DEAE-cellulose, hydroxyapatite, Phenyl-Sepharose, Mono P, Mono Q, and HPLC gel filtration columns, sulochrin oxidase was purified to apparent homogeneity [5].


  1. Rational elimination of Aspergillus terreus sulochrin production. Couch, R.D., Gaucher, G.M. J. Biotechnol. (2004) [Pubmed]
  2. New chlorinated diphenyl ethers from an Aspergillus species. Hargreaves, J., Park, J.O., Ghisalberti, E.L., Sivasithamparam, K., Skelton, B.W., White, A.H. J. Nat. Prod. (2002) [Pubmed]
  3. Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation. Ohashi, H., Ueno, A., Nakao, T., Ito, J., Kimura, K., Ishikawa, M., Kawai, H., Iijima, H., Osawa, T. Bioorg. Med. Chem. Lett. (1999) [Pubmed]
  4. Sulochrin inhibits eosinophil activation and chemotaxis. Ohashi, H., Motegi, Y., Kita, H., Gleich, G.J., Miura, T., Ishikawa, M., Kawai, H., Fukamachi, H. Inflamm. Res. (1998) [Pubmed]
  5. Purification and characterization of sulochrin oxidase from Penicillium frequentans. Huang, K., Yoshida, Y., Mikawa, K., Fujii, I., Ebizuka, Y., Sankawa, U. Biol. Pharm. Bull. (1996) [Pubmed]
  6. Sulochrin inhibits eosinophil degranulation. Ohashi, H., Ishikawa, M., Ito, J., Ueno, A., Gleich, G.J., Kita, H., Kawai, H., Fukamachi, H. J. Antibiot. (1997) [Pubmed]
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