High impact information on C00495

• Sulochrin is a co-metabolite produced during the Aspergillus terreus lovastatin fermentation [1].
• Two new chlorinated diphenyl ethers (5, 6) have been isolated from the culture broth of an Aspergillus species obtained from leaf litter, together with the known benzophenone sulochrin (1), the grisandiene geodin (2), and the diphenyl ether asterric acid (3) [2].
• Effects of ortho-substituent groups of sulochrin on inhibitory activity to eosinophil degranulation [3].
• RESULTS: Sulochrin inhibited EDN release by eosinophils stimulated with sIgA-beads [4].
• Finally, sulochrin potently inhibited LTB4-induced infiltration of eosinophils into the skin of guinea-pig in vivo [4].

Biological context of C00495

• Sulochrin inhibits eosinophil activation and chemotaxis [4].
• The enzyme showed high substrate specificity for benzophenone compounds such as sulochrin and dihydrogeodin [5].

Anatomical context of C00495

• Sulochrin inhibits eosinophil degranulation [6].

Associations of C00495 with other chemical compounds

• MATERIALS AND METHODS: We examined the effects of sulochrin on degranulation of human eosinophils stimulated with platelet-activating factor (PAF) or Sepharose 4B beads coated with secretory IgA (sIgA) or IgG [4].
• The effects of sulochrin on other effector functions of human eosinophils, including superoxide anion (O2-) production, leukotriene (LT) C4 release, and interleukin (IL)-8 production induced by sIgA-beads were also studied [4].
• Sulochrin oxidase, an enzyme catalyzing regio- and stereospecific phenol oxidative coupling reaction to form (+)-bisdechlorogeodin from sulochrin, was isolated from Penicillium frequentans CMI 96659 [5].
• By chromatographies on DEAE-cellulose, hydroxyapatite, Phenyl-Sepharose, Mono P, Mono Q, and HPLC gel filtration columns, sulochrin oxidase was purified to apparent homogeneity [5].

References