Disease relevance of BRN 1725372

• Recent studies of Salmonella lipid A indicate that 3-hydroxytetradecanoic acid (3-OH-14:0) residues are directly linked to the glucosamine backbone and the nonhydroxylated fatty acids (principally dodecanoic and tetradecanoic acids) are esterified to the hydroxyl groups of some of the 3-OH-14:0 molecules [1].
• The Gram-negative Escherichia coli organism showed significant amounts of 3-hydroxymyristic acid derivatives and degradation products in Py-GC-MS analyses [2].
• Method for detecting the 3-hydroxymyristic acid component of the endotoxins of gram-negative bacteria in compost samples [3].
• The absence of beta-hydroxymyristic acid and glucosamine in Brucella lipid dissociates it from the enteric lipid A [4].

High impact information on BRN 1725372

• 3-Hydroxymyristic acid is a component of lipopolysaccharides in the cell walls of Gram-negative organisms [2].
• The content of 3-hydroxymyristic acid from Escherichia coli lipopolysaccharide in peritoneal fluid and plasma from rats was determined by two-dimensional gas chromatography with electron-capture detection of the 3-O-pentafluorobenzoyl methyl ester derivative [5].
• Beta-Hydroxymyristic acid, the typical fatty acid of enterobacterial LPS, is lacking [6].
• In the presence of H2O2, the recombinant ybdT gene product hydroxylated myristic acid to produce beta-hydroxymyristic acid and alpha-hydroxymyristic acid which were determined by high-performance liquid chromatography (HPLC) and gas chromatography-mass spectrometry [7].
• Lipid A of S. sputigena consisted mainly of fatty acids such as undecanoic, tridecanoic, tridecenoic, 3-hydroxytridecanoic and 3-hydroxytetradecanoic acid in a molar ratio of 0.4:1.0:0.3:4.0:0.5 (mol/mol tridecanoic acid) [8].

Biological context of BRN 1725372

• The samples of S-LPS differed both in the length of O-specific polysaccharide (n = 1 and 4) and in the acylation degree of the 3-hydroxytetradecanoic acid residues of the lipid A moiety (12-66%) [9].

References