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Chemical Compound Review:

AC1L4UIY [(2R,3R,4R,5R,6R)-5- acetamido-4,6...

Synonyms: AR-1L8557, 4-F-Glcnac

Dimitroff, C.J. et al., Woynarowska, B. et al., Dimitroff, C.J. et al., Descheny, L. et al.

Dimitroff, Kupper, Sackstein,

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Disease relevance of 4-F-Glcnac

To analyze 4-F-GlcNAc efficacy in dampening effector T cell migration to inflamed skin, we elicited allergic contact hypersensitivity (CHS) reactions in mice treated with 4-F-GlcNAc [1].
These results indicate that 4-F-GlcNAc treatment can selectively downregulate the P-selectin ligand activity and potentially prevent dermal dissemination of cutaneous lymphomas [2].

High impact information on 4-F-Glcnac

We also investigated 4-F-GlcNAc efficacy on lymphocyte E-selectin ligand expression in LNs draining antigen-sensitized skin and on other immunological processes requisite for CHS responses [1].
Our results showed that 4-F-GlcNAc treatment attenuated lymphocyte E-selectin ligand expression in skin-draining LNs and prevented CHS reactions [1].
After exposure to 4-F-GlcNAc, lysosomal associated membrane proteins (lamp) 1 and 2, and carcinoembryonic antigen (CEA) detected in HT-29 cells were of lower molecular weight, probably due to impaired glycosylation [3].
Treatment of HT-29 cells with 4-F-GlcNAc led to reduced cell surface expression of terminal lactosamine, sialy-Le(x) and sialyl-Le(a), as determined by Western blotting and flow cytometry [3].

Biological context of 4-F-Glcnac

These observations establish a potential treatment approach for targeting pathologic lymphocyte trafficking to skin and indicate that 4-F-GlcNAc may be a promising agent for treatment of dermal tropism associated with malignancies and inflammatory disorders [4].

References

Prevention of leukocyte migration to inflamed skin with a novel fluorosugar modifier of cutaneous lymphocyte-associated antigen. Dimitroff, C.J., Kupper, T.S., Sackstein, R. J. Clin. Invest. (2003) [Pubmed]
Ameliorating skin-homing receptors on malignant T cells with a fluorosugar analog of N-acetylglucosamine: P-selectin ligand is a more sensitive target than E-selectin ligand. Descheny, L., Gainers, M.E., Walcheck, B., Dimitroff, C.J. J. Invest. Dermatol. (2006) [Pubmed]
Inhibition of human HT-29 colon carcinoma cell adhesion by a 4-fluoro-glucosamine analogue. Woynarowska, B., Dimitroff, C.J., Sharma, M., Matta, K.L., Bernacki, R.J. Glycoconj. J. (1996) [Pubmed]
Glycosylation-dependent inhibition of cutaneous lymphocyte-associated antigen expression: implications in modulating lymphocyte migration to skin. Dimitroff, C.J., Bernacki, R.J., Sackstein, R. Blood (2003) [Pubmed]

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