Disease relevance of Felidae

• The relationship of the Australian FIV isolates to other domestic isolates as well as eight lentiviral isolates from wild felidae (panthers) published previously, was investigated further by constructing a phylogenetic tree based on the pol sequence [1].

High impact information on Felidae

• Comparative genome organization of the major histocompatibility complex: lessons from the Felidae [2].
• Phylogenetic assessment of introns and SINEs within the Y chromosome using the cat family felidae as a species tree [3].
• DNA sequence comparisons of two mitochondrial DNA genes were used to infer phylogenetic relationships among 17 Felidae species, notably 15 in the previously described pantherine lineage [4].
• In this study, we investigated the cross-reactivity pattern of IgE and IgG4 antibodies to the major feline allergen, Fel d I. We studied the IgE and IgG4 response of 11 cat-allergic patients against Fel d I-like structures in eight members of the Felidae family: ocelot, puma, serval, siberian tiger, lion, jaguar, snow leopard, and caracal [5].
• The overall amount of genetic variation observed among MHC class I genes in the Felidae family is no greater than the amount of variation within any outbred cat species (i.e., domestic cat, ocelot) [6].

Biological context of Felidae

• A simultaneous analysis of international breeding records for captive female clouded leopards demonstrated that 46.2% of parturitions occurred in March and April, indicating that most estrual periods occurred from late December through February [7].
• Molecular phylogeny of the cat family Felidae is derived using two mitochondrial genes, cytochrome b and 12S rRNA [8].
• For maintaining sperm motility, there was no benefit (P > or = 0.05) to supplementing PBS with low (5%) or high (20%) concentrations of snow leopard serum (SLS) versus FCS or BSA [9].

Anatomical context of Felidae

• Seasonal analysis of semen characteristics, serum testosterone and fecal androgens in the ocelot (Leopardus pardalis), margay (L. wiedii) and tigrina (L. tigrinus) [10].

Associations of Felidae with chemical compounds

• A circannual analysis was made of serum cortisol, luteinizing hormone (LH), and testosterone concentrations in the male clouded leopard (Neofelis nebulosa) [11].
• These data demonstrate that the clouded leopard, compared to other felids, produces markedly elevated concentrations of cortisol, which are likely related to an aggressive behavioral temperament.(ABSTRACT TRUNCATED AT 400 WORDS)[11]
• Natural versus chorionic gonadotropin-induced ovarian responses in the clouded leopard (Neofelis nebulosa) assessed by fecal steroid analysis [12].
• On nine occasions, clouded leopards ovulated spontaneously (based on elevated fecal P4 metabolite concentrations) in the absence of mating [12].
• Serum concentrations of oestradiol and progesterone and frequency of sexual behaviour during the normal oestrous cycle in the snow leopard (Panthera uncia) [13].

Gene context of Felidae

• A phylogenetic analysis of DNA sequences from three rapidly evolving mitochondrial genes (16S rRNA, NADH-5, and ATP-8) indicate that the Andean mountain cat is a distinct species belonging to the ocelot lineage [14].
• The cat family Felidae was used as a species tree to assess the phylogenetic performance of genes, and their embedded SINE elements, within the nonrecombining region of the Y chromosome (NRY) [3].
• Characterization of the prolactin (PRL) amino acid (aa) or cDNA sequences has not been reported for any member of the Felidae family [15].
• Together, these data suggest that protein tyrosine kinase mechanisms appear conserved within the family Felidae and are regulated by a cAMP/protein kinase A pathway [16].
• Carnivora: the primary structure of the major hemoglobin component from adult European lynx (Lynx lynx, Felidae) [17].

Analytical, diagnostic and therapeutic context of Felidae

• Ongoing studies are investigating the potential of in vitro fertilization (IVF), embryo cryopreservation and embryo transfer for genetic management of ocelots and tigrinas [18].
• Immobilization of wild ocelots with tiletamine and zolazepam in southern Texas [19].

References