Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

Editor

Personal info

View

About

Terms

Javascript disabled

Please enable Javascript support in your browser to use this application.

Instructions on how to enable JavaScript on different browsers can be found here: http://www.google.com/support/bin/answer.py?answer=23852.

[edit this page]

Chemical Compound Review:

Methyldopamine 4-(2-aminopropyl)benzene-1,2- diol

Synonyms: CHEMBL28278, SureCN633687, AG-F-24470, CTK4H5424, LS-136406, ...

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Methyldopamine

These results suggest that the tachycardia observed in conscious rats following alpha-MD administration is caused by stimulation of cardiac beta-adrenoceptors following its conversion to alpha-methyldopamine in cardiac sympathetic neurons [1].

High impact information on Methyldopamine

The results of the experiment showed significant correlations between TL platelet PST activity and the proportion of alpha-methyldopamine excreted as a sulfate conjugate, and between RBC COMT activity and the proportion of methyldopa excreted as an O-methyl metabolite [2].
Dopa decarboxylase (DDC) catalyzes the cleavage of alpha-methylDopa into 3,4-dihydroxyphenylacetone and ammonia, via the intermediate alpha-methyldopamine, which does not accumulate during catalysis [3].
These data suggest that alpha-methyl-m-tyramine in rat striatum is formed by the enzyme tyrosine hydroxylase on substrate AMPA, rather than by ring dehydroxylation of alpha-methyldopa and alpha-methyldopamine [4].
1. Intraventricular alpha-methyldopamine (50-200 mug) produced a dose-related fall in blood pressure in conscious spontaneously hypertensive rats [5].
3. Pretreatment with U-14,624, a selective central dopamine-beta-hydroxylase inhibitor, prevented the hypotensive effect of alpha-methyldopamine [5].

Anatomical context of Methyldopamine

Rat brain microsomes contain a cytochrome P-450-dependent monooxygenase which synthesizes catecholamphetamine from p-hydroxyamphetamine [6].
Thus, the aim of the present study was to evaluate the effects of MDA and alpha-methyldopamine (alpha-MeDA), a major metabolite of MDA, in freshly isolated rat hepatocyte suspensions [7].
The alpha 1- and alpha 2-adrenergic effects of the stereoisomers of alpha-methyldopamine were evaluated in guinea pig aorta and field-stimulated guinea pig ileum, respectively, in order to establish the stereochemical requirements of these receptors for alpha-methyl substituted phenethylamines [8].

Associations of Methyldopamine with other chemical compounds

Methyldopa and alpha-methyldopamine are substrates for the TL but not for the TS form of PST [2].
2 MD, alpha-methyldopamine (MDA) and alpha-methylnoradrenaline (MNA) were tested as substrates for human platelet PST [9].
The drugs of choice for control of blood pressure were hydralazine, alpha-methyldopamine, and cardioselective beta-blockers [10].

References

Mechanism of the tachycardia following systemic alpha-methyldopa administration in conscious rats. van der Maas, M.L., Head, G.A., de Jong, W. J. Cardiovasc. Pharmacol. (1986) [Pubmed]
Platelet phenol sulfotransferase and erythrocyte catechol-O-methyltransferase activities: correlation with methyldopa metabolism. Campbell, N.R., Dunnette, J.H., Mwaluko, G., Van Loon, J., Weinshilboum, R.M. Clin. Pharmacol. Ther. (1984) [Pubmed]
Reaction of dopa decarboxylase with alpha-methyldopa leads to an oxidative deamination producing 3,4-dihydroxyphenylacetone, an active site directed affinity label. Bertoldi, M., Dominici, P., Moore, P.S., Maras, B., Voltattorni, C.B. Biochemistry (1998) [Pubmed]
The effects of (+)-amphetamine, alpha-methyltyrosine, and alpha-methylphenylalanine on the concentrations of m-tyramine and alpha-methyl-m-tyramine in rat striatum. Dougan, D.F., Duffield, A.M., Duffield, P.H., Wade, D.N. Br. J. Pharmacol. (1983) [Pubmed]
Studies on the hypotensive action of alpha-methyldopamine. Finch, L., Hersom, A., Hicks, P. Br. J. Pharmacol. (1975) [Pubmed]
Formation of alpha-methyldopamine ("Catecholamphetamine") from p-hydroxyamphetamine by rat brain microsomes. Hoffman, A.R., Sastry, B.V., Axelrod, J. Pharmacology (1979) [Pubmed]
Hepatotoxicity of 3,4-methylenedioxyamphetamine and alpha-methyldopamine in isolated rat hepatocytes: formation of glutathione conjugates. Carvalho, M., Milhazes, N., Remião, F., Borges, F., Fernandes, E., Amado, F., Monks, T.J., Carvalho, F., Bastos, M.L. Arch. Toxicol. (2004) [Pubmed]
Stereochemical requirements of alpha 2-adrenergic receptors for alpha-methyl substituted phenethylamines. Ruffolo, R.R., Waddell, J.E. Life Sci. (1982) [Pubmed]
alpha-Methyldopa, alpha-methyldopamine an alpha-methylnoradrenaline: substrates for the thermolabile form of human platelet phenol sulphotransferase. Mwaluko, G., Weinshilboum, R. British journal of clinical pharmacology. (1982) [Pubmed]
How do perinatologists manage preeclampsia? Catanzarite, V., Quirk, J.G., Aisenbrey, G. American journal of perinatology. (1991) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenes Open Access Licence Privacy Policy Terms of Use apsburg