Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Abruquinone A 5-[(3R)-6,7-dimethoxychroman- 3-yl]-2,3...

Synonyms: AC1L59FT, 71593-10-7

Wang, J.P. et al., Hsu, M.F. et al., Wang, J.P. et al.

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Disease relevance of Abruquinone A

Polymyxin B-induced hind-paw edema was suppressed by abruquinone A, an isoflavanquinone isolated from Abrus precatorius, in normal as well in adrenalectomized mice [1].

High impact information on Abruquinone A

Collectively, these results indicate that the inhibition of respiratory burst in rat neutrophils by abruquinone A is mediated partly by the blockade of phospholipase C (PLC) and phospholipase D (PLD) pathways, and by suppressing the function of NADPH oxidase through the interruption of electron transport [2].
7. The cellular formation of phosphatidic acid (PA) and phosphatidylethanol (PEt) induced by fMLP/ CB was inhibited by abruquinone A with IC50 values of 2.2 +/- 0.6 micrograms ml-1 and 2.5 +/- 0.3 micrograms ml-1, respectively [2].
5. Abruquinone A did not affect the enzyme activaties of neutrophil cytosolic protein kinase C (PKC) and porcine heart protein kinase A (PKA) [2].
These results indicate that abruquinone A inhibits the activity of phosphoinositide-specific phospholipase C in neutrophils [3].
In addition, abruquinone A suppressed the bradykinin- and substance P-induced ear edema to a significantly greater extent than diphenhydramine/methysergide did [1].

Chemical compound and disease context of Abruquinone A

Histamine-, serotonin-, bradykinin- and substance P-induced plasma extravasation in ear edema was also suppressed by abruquinone A [1].

Biological context of Abruquinone A

Cellular localization of the inhibitory action of abruquinone A against respiratory burst in rat neutrophils [2].
These results suggest that the anti-inflammatory effect of abruquinone A is mediated partly via the suppression of the release of chemical mediators from mast cells and partly via the prevention of vascular permeability changes caused by mediators [1].

References

Inhibition of plasma extravasation by abruquinone A, a natural isoflavanquinone isolated from Abrus precatorius. Wang, J.P., Hsu, M.F., Chang, L.C., Kuo, J.S., Kuo, S.C. Eur. J. Pharmacol. (1995) [Pubmed]
Cellular localization of the inhibitory action of abruquinone A against respiratory burst in rat neutrophils. Hsu, M.F., Raung, S.L., Tsao, L.T., Kuo, S.C., Wang, J.P. Br. J. Pharmacol. (1997) [Pubmed]
Inhibition by abruquinone A of phosphoinositide-specific phospholipase C activation in rat neutrophils. Wang, J.P., Hsu, M.F., Kuo, S.C. Eur. J. Pharmacol. (1997) [Pubmed]

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