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Gene Review

Nox1  -  NADPH oxidase 1

Rattus norvegicus

Synonyms: MOX-1, Mitogenic oxidase 1, Mox1, NADH/NADPH mitogenic oxidase subunit P65-MOX, NOH-1, ...
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Disease relevance of Nox1


High impact information on Nox1


Chemical compound and disease context of Nox1


Biological context of Nox1


Anatomical context of Nox1


Associations of Nox1 with chemical compounds


Physical interactions of Nox1

  • These results suggest that the ROS, perhaps H(2)O(2), acts as an intracellular signal mediator for NGF-induced neuronal differentiation and that NGF-stimulated ROS production is regulated by Rac1 and a flavoprotein-binding protein similar to the phagocytic NADPH oxidase [18].

Regulatory relationships of Nox1


Other interactions of Nox1

  • Ang II-induced NFAT activation was suppressed by diphenyleneiodonium (an NADPH oxidase inhibitor), dominant negative (DN)-Rac, DN-p47(phox), and an inhibitor of Galpha(12/13) (Galpha(12/13)-specific regulator of G protein signaling domain of p115RhoGEF, p115-regulator of G protein signaling (RGS)) [14].
  • In conclusion, Nox4 and Nox1 are upregulated by the renin-angiotensin system [13].
  • We used double-stranded interfering RNAs (siRNAs) in Sprague Dawley rats in vivo to test the hypothesis that an increase in the p22phox component of NADPH oxidase is required for this response [11].
  • This is offset by strong protective effects of AT2-R, which are accompanied by decreased expression of p22phox, Nox-1, and p67phox [24].
  • Significantly up-regulated NADPH oxidase, caveolin-1 and RhoA expression were also detected in ventricular tissue of the iron-deficient group [25].

Analytical, diagnostic and therapeutic context of Nox1


  1. NADPH oxidase is involved in prostaglandin F2alpha-induced hypertrophy of vascular smooth muscle cells: induction of NOX1 by PGF2alpha. Katsuyama, M., Fan, C., Yabe-Nishimura, C. J. Biol. Chem. (2002) [Pubmed]
  2. Superoxide anion is elevated in sympathetic neurons in DOCA-salt hypertension via activation of NADPH oxidase. Dai, X., Cao, X., Kreulen, D.L. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  3. NADPH oxidase mediates interleukin-6 expression in cerulein-stimulated pancreatic acinar cells. Yu, J.H., Lim, J.W., Kim, H., Kim, K.H. Int. J. Biochem. Cell Biol. (2005) [Pubmed]
  4. Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4. Wendt, M.C., Daiber, A., Kleschyov, A.L., Mülsch, A., Sydow, K., Schulz, E., Chen, K., Keaney, J.F., Lassègue, B., Walter, U., Griendling, K.K., Münzel, T. Free Radic. Biol. Med. (2005) [Pubmed]
  5. Vascular but not cardiac remodeling is associated with superoxide production in angiotensin II hypertension. Zhou, M.S., Jaimes, E.A., Raij, L. J. Hypertens. (2005) [Pubmed]
  6. CD18/ICAM-1-dependent oxidative NF-kappaB activation leading to nitric oxide production in rat Kupffer cells cocultured with syngeneic hepatoma cells. Kurose, I., Saito, H., Miura, S., Ebinuma, H., Higuchi, H., Watanabe, N., Zeki, S., Nakamura, T., Takaishi, M., Ishii, H. J. Clin. Invest. (1997) [Pubmed]
  7. Angiotensin II-mediated hypertension in the rat increases vascular superoxide production via membrane NADH/NADPH oxidase activation. Contribution to alterations of vasomotor tone. Rajagopalan, S., Kurz, S., Münzel, T., Tarpey, M., Freeman, B.A., Griendling, K.K., Harrison, D.G. J. Clin. Invest. (1996) [Pubmed]
  8. Brain-derived neurotrophic factor can act as a pronecrotic factor through transcriptional and translational activation of NADPH oxidase. Kim, S.H., Won, S.J., Sohn, S., Kwon, H.J., Lee, J.Y., Park, J.H., Gwag, B.J. J. Cell Biol. (2002) [Pubmed]
  9. NADPH-oxidase expression and in situ production of superoxide by osteoclasts actively resorbing bone. Steinbeck, M.J., Appel, W.H., Verhoeven, A.J., Karnovsky, M.J. J. Cell Biol. (1994) [Pubmed]
  10. Nebivolol Inhibits Superoxide Formation by NADPH Oxidase and Endothelial Dysfunction in Angiotensin II-Treated Rats. Oelze, M., Daiber, A., Brandes, R.P., Hortmann, M., Wenzel, P., Hink, U., Schulz, E., Mollnau, H., von Sandersleben, A., Kleschyov, A.L., Mülsch, A., Li, H., Förstermann, U., Münzel, T. Hypertension (2006) [Pubmed]
  11. RNA silencing in vivo reveals role of p22phox in rat angiotensin slow pressor response. Modlinger, P., Chabrashvili, T., Gill, P.S., Mendonca, M., Harrison, D.G., Griendling, K.K., Li, M., Raggio, J., Wellstein, A., Chen, Y., Welch, W.J., Wilcox, C.S. Hypertension (2006) [Pubmed]
  12. Transactivation of the EGF receptor and a PI3 kinase-ATF-1 pathway is involved in the upregulation of NOX1, a catalytic subunit of NADPH oxidase. Fan, C., Katsuyama, M., Nishinaka, T., Yabe-Nishimura, C. FEBS Lett. (2005) [Pubmed]
  13. Upregulation of the vascular NAD(P)H-oxidase isoforms Nox1 and Nox4 by the renin-angiotensin system in vitro and in vivo. Wingler, K., Wünsch, S., Kreutz, R., Rothermund, L., Paul, M., Schmidt, H.H. Free Radic. Biol. Med. (2001) [Pubmed]
  14. Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts. Fujii, T., Onohara, N., Maruyama, Y., Tanabe, S., Kobayashi, H., Fukutomi, M., Nagamatsu, Y., Nishihara, N., Inoue, R., Sumimoto, H., Shibasaki, F., Nagao, T., Nishida, M., Kurose, H. J. Biol. Chem. (2005) [Pubmed]
  15. NAD(P)H oxidases in rat basilar arterial endothelial cells. Ago, T., Kitazono, T., Kuroda, J., Kumai, Y., Kamouchi, M., Ooboshi, H., Wakisaka, M., Kawahara, T., Rokutan, K., Ibayashi, S., Iida, M. Stroke (2005) [Pubmed]
  16. Nitric oxide down-regulates the expression of the catalytic NADPH oxidase subunit Nox1 in rat renal mesangial cells. Plesková, M., Beck, K.F., Behrens, M.H., Huwiler, A., Fichtlscherer, B., Wingerter, O., Brandes, R.P., Mülsch, A., Pfeilschifter, J. FASEB J. (2006) [Pubmed]
  17. Antioxidant effect of adrenomedullin on angiotensin II-induced reactive oxygen species generation in vascular smooth muscle cells. Yoshimoto, T., Fukai, N., Sato, R., Sugiyama, T., Ozawa, N., Shichiri, M., Hirata, Y. Endocrinology (2004) [Pubmed]
  18. Nerve growth factor-induced neuronal differentiation requires generation of Rac1-regulated reactive oxygen species. Suzukawa, K., Miura, K., Mitsushita, J., Resau, J., Hirose, K., Crystal, R., Kamata, T. J. Biol. Chem. (2000) [Pubmed]
  19. Lysophosphatidylcholine activates extracellular signal-regulated kinases 1/2 through reactive oxygen species in rat vascular smooth muscle cells. Yamakawa, T., Tanaka, S., Yamakawa, Y., Kamei, J., Numaguchi, K., Motley, E.D., Inagami, T., Eguchi, S. Arterioscler. Thromb. Vasc. Biol. (2002) [Pubmed]
  20. Endothelin mediates superoxide production and vasoconstriction through activation of NADPH oxidase and uncoupled nitric-oxide synthase in the rat aorta. Loomis, E.D., Sullivan, J.C., Osmond, D.A., Pollock, D.M., Pollock, J.S. J. Pharmacol. Exp. Ther. (2005) [Pubmed]
  21. TGF-beta impairs renal autoregulation via generation of ROS. Sharma, K., Cook, A., Smith, M., Valancius, C., Inscho, E.W. Am. J. Physiol. Renal Physiol. (2005) [Pubmed]
  22. The effect of the tert-butylquinone metabolite of butylated hydroxyanisole on cytochrome P-450 monooxygenase activity. Cummings, S.W., Curtis, B.B., Peterson, J.A., Prough, R.A. Xenobiotica (1990) [Pubmed]
  23. Involvement of NADH/NADPH oxidase-derived superoxide in experimental vasospasm induced by periarterial blood in rat femoral artery. Choi, J.M., Kim, C.D., Hong, K.W. Life Sci. (2001) [Pubmed]
  24. Effects of ANG II type 1 and 2 receptors on oxidative stress, renal NADPH oxidase, and SOD expression. Chabrashvili, T., Kitiyakara, C., Blau, J., Karber, A., Aslam, S., Welch, W.J., Wilcox, C.S. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2003) [Pubmed]
  25. Dietary iron deficiency induces ventricular dilation, mitochondrial ultrastructural aberrations and cytochrome c release: involvement of nitric oxide synthase and protein tyrosine nitration. Dong, F., Zhang, X., Culver, B., Chew, H.G., Kelley, R.O., Ren, J. Clin. Sci. (2005) [Pubmed]
  26. Expression and cellular localization of classic NADPH oxidase subunits in the spontaneously hypertensive rat kidney. Chabrashvili, T., Tojo, A., Onozato, M.L., Kitiyakara, C., Quinn, M.T., Fujita, T., Welch, W.J., Wilcox, C.S. Hypertension (2002) [Pubmed]
  27. Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. Marshall, C., Mamary, A.J., Verhoeven, A.J., Marshall, B.E. Am. J. Respir. Cell Mol. Biol. (1996) [Pubmed]
  28. Atorvastatin protects against cerebral infarction via inhibition of NADPH oxidase-derived superoxide in ischemic stroke. Hong, H., Zeng, J.S., Kreulen, D.L., Kaufman, D.I., Chen, A.F. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
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