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Chemical Compound Review

Diisopropanol     hexane-2,5-diol

Synonyms: AGN-PC-0CM9QL, NSC-3699, ACMC-1ACZ0, H11904_ALDRICH, AG-E-95516, ...
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Disease relevance of NSC 3699


High impact information on NSC 3699


Biological context of NSC 3699


Anatomical context of NSC 3699

  • A study has been made of the structural changes of nodal and paranodal regions of the nodes of Ranvier of peripheral nerves of rats in which marked accumulations of neurofilaments have occurred within axons under the influence of 2,5-hexanediol over 10 weeks [8].

Analytical, diagnostic and therapeutic context of NSC 3699

  • The pattern of recovery of axons in the nervous system of rats following 2,5-hexanediol intoxication: a question of rheology [9]?


  1. Recovery from 2,5-hexanediol intoxication of the retinotectal tract of the rat. An ultrastructural study. Jones, H.B., Cavanagh, J.B. Acta Neuropathol. (1982) [Pubmed]
  2. Toxicity of n-hexane and 2,5-hexanediol to the haemopoietic system: a preliminary report. Goel, S.K., Rao, G.S., Krishnamurti, C.R. Xenobiotica (1987) [Pubmed]
  3. On the mechanism of the unexpected facile formation of meso-diacetate products in enzymatic acetylation of alkanediols. Edin, M., Bäckvall, J.E. J. Org. Chem. (2003) [Pubmed]
  4. Rat lung and liver microsomal cytochrome P-450 isozymes involved in the hydroxylation of n-hexane. Toftgård, R., Haaparanta, T., Eng, L., Halpert, J. Biochem. Pharmacol. (1986) [Pubmed]
  5. In vitro effect of n-hexane and its metabolites on selected enzymes in glycolysis, pentose phosphate pathway and citric acid cycle. Sabri, M.I. Brain Res. (1984) [Pubmed]
  6. Effect of exposure to 2,5-hexanediol in light or darkness on the retina of albino and pigmented rats. II. Electrophysiology. Nylén, P., Bäckström, B., Hagman, M., Johnson, A.C., Collins, V.P., Höglund, G. Arch. Toxicol. (1993) [Pubmed]
  7. Effect of 2,5-hexanediol on immunocompetence of mice. Kannan, K., Singh, K.P., Goel, S.K., Shanker, R. Environmental research. (1985) [Pubmed]
  8. Distortions of the nodes of Ranvier from axonal distension by filamentous masses in hexacarbon intoxication. Jones, H.B., Cavanagh, J.B. J. Neurocytol. (1983) [Pubmed]
  9. The pattern of recovery of axons in the nervous system of rats following 2,5-hexanediol intoxication: a question of rheology? Cavanagh, J.B. Neuropathol. Appl. Neurobiol. (1982) [Pubmed]
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