Disease relevance of NSC 3699

• Rats were given 2,5-hexanediol, a metabolite of n-hexane, in the drinking water until they developed a marked degree of paresis over about 7 weeks and were then allowed to recover naturally [1].
• Toxicity of n-hexane and 2,5-hexanediol to the haemopoietic system: a preliminary report [2].

High impact information on NSC 3699

• The mechanism of the unexpected facile formation of meso-diacetate previously observed in the enzymatic resolution of dl/meso mixtures of 2,4-pentanediol and 2,5-hexanediol with Candida antarctica lipase B has been elucidated [3].
• Similarly, formation of 2,5-hexanediol from 2-hexanol was catalyzed by a P-450 isozyme different from cytochrome P-450-PB-B and present in liver but not in lung microsomes [4].
• MnBK and 2,5-HD both inhibited GAPDH and PFK activities selectively. n-Hexane and 2-hexanol had no effect on GAPDH and PFK activities; 5-hydroxy-2-hexanone and 2,5-hexanediol exhibited a slight inhibitory effect on these enzymes [5].
• Effect of exposure to 2,5-hexanediol in light or darkness on the retina of albino and pigmented rats. II. Electrophysiology [6].
• Spleen and bone marrow were the target sites for the metabolite 2,5-hexanediol, whereas n-hexane as such does not affect these organs [2].

Biological context of NSC 3699

• Effect of 2,5-hexanediol on immunocompetence of mice [7].
• Mice were exposed to 2,5-hexanediol at a 1/5 LD50 dose level for 7 days [7].

Anatomical context of NSC 3699

• A study has been made of the structural changes of nodal and paranodal regions of the nodes of Ranvier of peripheral nerves of rats in which marked accumulations of neurofilaments have occurred within axons under the influence of 2,5-hexanediol over 10 weeks [8].

Analytical, diagnostic and therapeutic context of NSC 3699

• The pattern of recovery of axons in the nervous system of rats following 2,5-hexanediol intoxication: a question of rheology [9]?

References