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Chemical Compound Review

DMAIII     dimethylarsinous acid

Synonyms: Me2AsOH, CCRIS 9226, AG-F-92321, CHEBI:23808, HMDB12216, ...
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Disease relevance of dimethylarsinous acid


High impact information on dimethylarsinous acid


Biological context of dimethylarsinous acid

  • This laboratory has studied the enzymology involved in the biotransformation of inorganic arsenic to dimethylarsinous acid (DMA(III)) and in human studies established that monomethylarsonous acid (MMA(III)) and DMA(III) appear in urine of people chronically exposed to arsenic [7].
  • Recent advances in arsenic metabolism have suggested that methylation of inorganic arsenic may be a toxification, rather than a detoxification, pathway and that trivalent methylated arsenic metabolites, particularly monomethylarsonous acid and dimethylarsinous acid, have a great deal of biological activity [8].

Anatomical context of dimethylarsinous acid


  1. Possible role of dimethylarsinous acid in dimethylarsinic acid-induced urothelial toxicity and regeneration in the rat. Cohen, S.M., Arnold, L.L., Uzvolgyi, E., Cano, M., St John, M., Yamamoto, S., Lu, X., Le, X.C. Chem. Res. Toxicol. (2002) [Pubmed]
  2. Methylated metabolites of arsenic trioxide are more potent than arsenic trioxide as apoptotic but not differentiation inducers in leukemia and lymphoma cells. Chen, G.Q., Zhou, L., Styblo, M., Walton, F., Jing, Y., Weinberg, R., Chen, Z., Waxman, S. Cancer Res. (2003) [Pubmed]
  3. Distinct gene expression profiles in immortalized human urothelial cells exposed to inorganic arsenite and its methylated trivalent metabolites. Su, P.F., Hu, Y.J., Ho, I.C., Cheng, Y.M., Lee, T.C. Environ. Health Perspect. (2006) [Pubmed]
  4. Arsenic speciation in urine from acute promyelocytic leukemia patients undergoing arsenic trioxide treatment. Wang, Z., Zhou, J., Lu, X., Gong, Z., Le, X.C. Chem. Res. Toxicol. (2004) [Pubmed]
  5. Sulfur-containing arsenical mistaken for dimethylarsinous acid [DMA(III)] and identified as a natural metabolite in urine: major implications for studies on arsenic metabolism and toxicity. Hansen, H.R., Raab, A., Jaspars, M., Milne, B.F., Feldmann, J. Chem. Res. Toxicol. (2004) [Pubmed]
  6. Dimethylarsine and trimethylarsine are potent genotoxins in vitro. Andrewes, P., Kitchin, K.T., Wallace, K. Chem. Res. Toxicol. (2003) [Pubmed]
  7. A review of the enzymology of arsenic metabolism and a new potential role of hydrogen peroxide in the detoxication of the trivalent arsenic species. Aposhian, H.V., Zakharyan, R.A., Avram, M.D., Sampayo-Reyes, A., Wollenberg, M.L. Toxicol. Appl. Pharmacol. (2004) [Pubmed]
  8. Recent advances in arsenic carcinogenesis: modes of action, animal model systems, and methylated arsenic metabolites. Kitchin, K.T. Toxicol. Appl. Pharmacol. (2001) [Pubmed]
  9. Animal species difference in the uptake of dimethylarsinous acid (DMA(III)) by red blood cells. Shiobara, Y., Ogra, Y., Suzuki, K.T. Chem. Res. Toxicol. (2001) [Pubmed]
  10. DNA damage induced by methylated trivalent arsenicals is mediated by reactive oxygen species. Nesnow, S., Roop, B.C., Lambert, G., Kadiiska, M., Mason, R.P., Cullen, W.R., Mass, M.J. Chem. Res. Toxicol. (2002) [Pubmed]
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