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MeSH Review

Iliac Artery

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Disease relevance of Iliac Artery


Psychiatry related information on Iliac Artery

  • Our results indicate that the polysulfonated naphthylurea suramin, a "non-specific drug" that interferes with multiple cellular proteins, inhibits neointimal formation in rabbit iliac arteries after balloon-catheter injury administered throughout the critical period of several weeks after the procedure [6].
  • METHODS AND RESULTS: PTA was performed in external iliac arteries of 12 atherosclerotic Yucatan pigs, of which 6 pigs (7 vessels) received the MMPI batimastat and 6 pigs (10 vessels) served as controls [7].

High impact information on Iliac Artery


Chemical compound and disease context of Iliac Artery

  • MATERIALS AND METHODS: New Zealand White rabbits were divided into control (n = 6, fed with a regular diet), hypercholesterolemic (n = 9, fed with a diet containing 0.5% cholesterol) and chronic cavernosal ischemia (CCI, n = 10, underwent balloon de-endothelialization of iliac arteries and received a diet containing 0.5% cholesterol) groups [12].
  • CONCLUSIONS: ES can be detected in the common femoral artery with Doppler ultrasound scanning in patients with iliac artery stenosis both before and soon after iliac PTA despite preangioplasty aspirin and intra-angioplasty heparin therapies [13].
  • Plasmid DNA encoding each of the three principal human VEGF isoforms (phVEGF121, phVEGF165, or phVEGF189) was applied to the hydrogel polymer coating of an angioplasty balloon and delivered percutaneously to one iliac artery of rabbits with operatively induced hindlimb ischemia [14].
  • Five lambs ( approximately 6 mo of age and 30 kg), with an external iliac artery and vein catheterized and fed to maintain body weight, were used to examine effects of close arterial infusion of insulin and branched-chain amino acids (BCAA) on net phenylalanine (Phe) uptake across the hind limb [15].
  • PURPOSE: To report endovascular occlusion of an internal iliac artery (IIA) aneurysm with an Amplatz nitinol vascular occlusion plug [16].

Biological context of Iliac Artery


Anatomical context of Iliac Artery


Associations of Iliac Artery with chemical compounds

  • BACKGROUND: Endurance athletes often have restrictions in flow in their iliac arteries during exercise [27].
  • New Zealand White rabbits fed a 1% cholesterol diet or a standard diet for 14 weeks underwent balloon denudation of the left iliac artery 4 weeks before death [28].
  • Under control conditions EDHF-type relaxations evoked by acetylcholine (ACh) in rabbit iliac arteries were transient, but in the presence of the cAMP phosphodiesterase inhibitor isobutylmethylxanthine (IBMX) or the cell permeant cAMP analog 8-bromo-cAMP, relaxations became sustained with their maxima potentiated approximately 2-fold [29].
  • Morphometric analysis of histologic sections of the left and right iliac arteries disclosed significant differences in luminal and total vessel areas (p less than .05), whereas arterial wall (intima and media) areas were similar (p = NS) [30].
  • Four weeks later, vasoreactivity was assessed angiographically during infusion of acetylcholine (Ach) before and after delivery of L-arginine or saline into the right or left iliac artery (800 mg/5 mL; 0.2 mL/min, 15 minutes) by use of a local drug-delivery balloon [31].

Gene context of Iliac Artery


Analytical, diagnostic and therapeutic context of Iliac Artery


  1. Mycotic aneurysm of the external iliac artery. A triad of clinical signs facilitating early diagnosis. Feinsod, F.M., Norfleet, R.G., Hoehn, J.L. JAMA (1977) [Pubmed]
  2. Therapeutic angiogenesis. A single intraarterial bolus of vascular endothelial growth factor augments revascularization in a rabbit ischemic hind limb model. Takeshita, S., Zheng, L.P., Brogi, E., Kearney, M., Pu, L.Q., Bunting, S., Ferrara, N., Symes, J.F., Isner, J.M. J. Clin. Invest. (1994) [Pubmed]
  3. Local treatment with antithrombotic drugs can prevent thrombus formation: an angioscopic and angiographic study. Tomaru, T., Nakamura, F., Fujimori, Y., Omata, M., Kawai, S., Okada, R., Murata, Y., Uchida, Y. J. Am. Coll. Cardiol. (1995) [Pubmed]
  4. Flexible tantalum stents for the treatment of iliac artery lesions: long-term patency, complications, and risk factors. Strecker, E.P., Boos, I.B., Hagen, B. Radiology. (1996) [Pubmed]
  5. Catheter-mediated delivery of adenoviral vectors expressing beta-adrenergic receptor kinase C-terminus inhibits intimal hyperplasia and luminal stenosis in rabbit iliac arteries. Luo, Z., Palasis, M., Yamakawa, M., Liu, L.X., Vincent, K.A., Trudell, L., Akita, G.A., Koch, W.J., Cheng, S.H., Gregory, R.J., Jiang, C. The journal of gene medicine. (2004) [Pubmed]
  6. Inhibitory mechanisms by which suramin may attenuate neointimal formation after balloon angioplasty. Gray, T.J., Strauss, B.H., Hinek, A. J. Cardiovasc. Pharmacol. (1999) [Pubmed]
  7. Shear-stress and wall-stress regulation of vascular remodeling after balloon angioplasty: effect of matrix metalloproteinase inhibition. Wentzel, J.J., Kloet, J., Andhyiswara, I., Oomen, J.A., Schuurbiers, J.C., de Smet, B.J., Post, M.J., de Kleijn, D., Pasterkamp, G., Borst, C., Slager, C.J., Krams, R. Circulation (2001) [Pubmed]
  8. Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. I. Is the extent of atherosclerosis related to resistance of LDL to oxidation? Sasahara, M., Raines, E.W., Chait, A., Carew, T.E., Steinberg, D., Wahl, P.W., Ross, R. J. Clin. Invest. (1994) [Pubmed]
  9. Effects of psychosocial stress on endothelium-mediated dilation of atherosclerotic arteries in cynomolgus monkeys. Williams, J.K., Kaplan, J.R., Manuck, S.B. J. Clin. Invest. (1993) [Pubmed]
  10. Percutaneous arterial gene transfer in a rabbit model. Efficiency in normal and balloon-dilated atherosclerotic arteries. Leclerc, G., Gal, D., Takeshita, S., Nikol, S., Weir, L., Isner, J.M. J. Clin. Invest. (1992) [Pubmed]
  11. A monoclonal antibody to human platelet glycoprotein IIIa detects a related protein in cultured human endothelial cells. Thiagarajan, P., Shapiro, S.S., Levine, E., DeMarco, L., Yalcin, A. J. Clin. Invest. (1985) [Pubmed]
  12. Relative roles of cyclooxygenase and nitric oxide synthase pathways in ischemia-induced increased contraction of cavernosal smooth muscle. Azadzoi, K.M., Krane, R.J., Saenz de Tejada, I., Goldstein, I., Siroky, M.B. J. Urol. (1999) [Pubmed]
  13. Detection of distal emboli in patients with peripheral arterial stenosis before and after iliac angioplasty: a prospective study. Al-Hamali, S., Baskerville, P., Fraser, S., Walters, H., Markus, H.S. J. Vasc. Surg. (1999) [Pubmed]
  14. Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo. Takeshita, S., Tsurumi, Y., Couffinahl, T., Asahara, T., Bauters, C., Symes, J., Ferrara, N., Isner, J.M. Lab. Invest. (1996) [Pubmed]
  15. Insulin stimulates phenylalanine uptake across the hind limb in fed lambs. Wester, T.J., Lobley(), G.E., Birnie, L.M., Lomax, M.A. J. Nutr. (2000) [Pubmed]
  16. Endovascular treatment of an internal iliac artery aneurysm using a nitinol vascular occlusion plug. Diehm, N., Kickuth, R., Silvestro, A., Schindera, S.T., Meier, B., Baumgartner, I., Schmidli, J., Triller, J., Mahler, F., Do, D.D. J. Endovasc. Ther. (2005) [Pubmed]
  17. Hemodynamic sequelae of regression of experimental atherosclerosis. Armstrong, M.L., Heistad, D.D., Marcus, M.L., Piegors, D.J., Abboud, F.M. J. Clin. Invest. (1983) [Pubmed]
  18. Effects and mechanism of action of aminophylline on cardiac function and regional blood flow distribution in conscious dogs. Rutherford, J.D., Vatner, S.F., Braunwald, E. Circulation (1981) [Pubmed]
  19. Apoptosis (programmed cell death) in arteries of the neonatal lamb. Cho, A., Courtman, D.W., Langille, B.L. Circ. Res. (1995) [Pubmed]
  20. Transgene delivery of plasmid DNA to smooth muscle cells and macrophages from a biostable polymer-coated stent. Takahashi, A., Palmer-Opolski, M., Smith, R.C., Walsh, K. Gene Ther. (2003) [Pubmed]
  21. The effect of NG-nitro-L-arginine methyl ester upon basal blood flow and endothelium-dependent vasodilatation in the dog hindlimb. White, D.G., Drew, G.M., Gurden, J.M., Penny, D.M., Roach, A.G., Watts, I.S. Br. J. Pharmacol. (1993) [Pubmed]
  22. Vascular endothelial genes that are responsive to tumor necrosis factor-alpha in vitro are expressed in atherosclerotic lesions, including inhibitor of apoptosis protein-1, stannin, and two novel genes. Horrevoets, A.J., Fontijn, R.D., van Zonneveld, A.J., de Vries, C.J., ten Cate, J.W., Pannekoek, H. Blood (1999) [Pubmed]
  23. Blood flow- and endothelium-mediated vasomotion of iliac arteries in conscious dogs. Young, M.A., Vatner, S.F. Circ. Res. (1987) [Pubmed]
  24. Peptide inhibition of myointimal proliferation by angiopeptin, a somatostatin analogue. Lundergan, C.F., Foegh, M.L., Ramwell, P.W. J. Am. Coll. Cardiol. (1991) [Pubmed]
  25. Angiotensin II and PDGF-BB stimulate beta(1)-integrin-mediated adhesion and spreading in human VSMCs. Kappert, K., Schmidt, G., Doerr, G., Wollert-Wulf, B., Fleck, E., Graf, K. Hypertension (2000) [Pubmed]
  26. Inflammatory response to stent implantation: differences in femoropopliteal, iliac, and carotid arteries. Schillinger, M., Exner, M., Mlekusch, W., Haumer, M., Ahmadi, R., Rumpold, H., Wagner, O., Minar, E. Radiology. (2002) [Pubmed]
  27. Detection and treatment of claudication due to functional iliac obstruction in top endurance athletes: a prospective study. Schep, G., Bender, M.H., van de Tempel, G., Wijn, P.F., de Vries, W.R., Eikelboom, B.C. Lancet (2002) [Pubmed]
  28. Hypercholesterolemia enhances macrophage recruitment and dysfunction of regenerated endothelium after balloon injury of the rabbit iliac artery. Weidinger, F.F., McLenachan, J.M., Cybulsky, M.I., Fallon, J.T., Hollenberg, N.K., Cooke, J.P., Ganz, P. Circulation (1991) [Pubmed]
  29. cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electrotonic conduction via gap junctions. Griffith, T.M., Chaytor, A.T., Taylor, H.J., Giddings, B.D., Edwards, D.H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  30. The mechanism of transluminal angioplasty: evidence for formation of aneurysms in experimental atherosclerosis. Sanborn, T.A., Faxon, D.P., Haudenschild, C., Gottsman, S.B., Ryan, T.J. Circulation (1983) [Pubmed]
  31. Local intramural delivery of L-arginine enhances nitric oxide generation and inhibits lesion formation after balloon angioplasty. Schwarzacher, S.P., Lim, T.T., Wang, B., Kernoff, R.S., Niebauer, J., Cooke, J.P., Yeung, A.C. Circulation (1997) [Pubmed]
  32. Marked reduction of mortality in salt-loaded Dahl salt-sensitive rats by the new, selective endothelin ETA receptor antagonist, J-105859. Okada, M., Nishino, M., Saito, M., Ikeda, T., Uehara, S., Okada, H., Niiyama, K., Ohtake, N., Hayama, T., Nishikibe, M. J. Hypertens. (2000) [Pubmed]
  33. Effects and mechanism of tissue-type plasminogen activator and plasminogen activator inhibitor on vascular smooth muscle cell proliferation. Xiaoli, M., Wenying, H., Mingpeng, S. International journal of cardiology. (1998) [Pubmed]
  34. Peroxidative stress in diabetic blood vessels. Reversal by pancreatic islet transplantation. Pieper, G.M., Jordan, M., Dondlinger, L.A., Adams, M.B., Roza, A.M. Diabetes (1995) [Pubmed]
  35. Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. II. Cellular composition and proliferation. Chang, M.Y., Sasahara, M., Chait, A., Raines, E.W., Ross, R. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  36. Treatment of acute limb ischemia by intramuscular injection of vascular endothelial growth factor gene. Tsurumi, Y., Kearney, M., Chen, D., Silver, M., Takeshita, S., Yang, J., Symes, J.F., Isner, J.M. Circulation (1997) [Pubmed]
  37. Reduction of restenosis after angioplasty in an atheromatous rabbit model by suicide gene therapy. Steg, P.G., Tahlil, O., Aubailly, N., Caillaud, J.M., Dedieu, J.F., Berthelot, K., Le Roux, A., Feldman, L., Perricaudet, M., Denèfle, P., Branellec, D. Circulation (1997) [Pubmed]
  38. Comparative trial of local pharmacotherapy with L-arginine, r-hirudin, and molsidomine to reduce restenosis after balloon angioplasty of stenotic rabbit iliac arteries. Kalinowski, M., Alfke, H., Bergen, S., Klose, K.J., Barry, J.J., Wagner, H.J. Radiology. (2001) [Pubmed]
  39. Inhibition of neointimal formation after stent placement with adenovirus-mediated gene transfer of I kappa B alpha in the hypercholesterolemic rabbit model: initial results. Cejna, M., Breuss, J.M., Bergmeister, H., de Martin, R., Xu, Z., Grgurin, M., Losert, U., Plenk, H., Binder, B.R., Lammer, J. Radiology. (2002) [Pubmed]
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